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Journal / Neuroscience / 正常小鼠β淀粉样肽侧脑室注射敏锐地诱导老年痴呆样认知缺陷…
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Neuroscience

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JoVE Journal Neuroscience
正常小鼠β淀粉样肽侧脑室注射敏锐地诱导老年痴呆样认知缺陷
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正常小鼠β淀粉样肽侧脑室注射敏锐地诱导老年痴呆样认知缺陷

Article DOI: 10.3791/53308-v • 08:01 min • March 16th, 2016
March 16th, 2016 •
1,2, 1, 1,3, 1,4, 1,4
1Center for Neuro-Medicine, Korea Institute of Science and Technology, 2Research Institute, GoshenBiotech, Inc., 3Department of Chemical and Biological Engineering, Princeton University, 4Biological Chemistry Program, Korea University of Science and Technology

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淀粉样蛋白β（Aβ）-injected动物模型能够确定的数量和Aβ片段的物种的管理，并降低每个研究组内的个体差异。本协议描述Aβ的脑室（ICV）注射立体定向仪，使生产正常小鼠老年痴呆样行为异常。

Tags

神经科学，第109，阿尔茨海默氏病，淀粉样蛋白β（Aβ），脑室内（ICV）注射，行为测试，认知缺陷，学习和记忆
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