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Hele genom sekventering af Candida glabrata for påvisning af markører af svampedræbende resistens
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Hele genom sekventering af Candida glabrata for påvisning af markører af svampedræbende resistens

Article DOI: 10.3791/56714-v • 08:46 min • December 28th, 2017
December 28th, 2017 •
*1, *1,2,3, 1,2, 1, 1, 1, 1, 1, 1, 4, 4,5, 6, 7, 1,3, 1,2,3
1Centre for Infectious Diseases and Microbiology-Public Health, Westmead Hospital, 2Centre for Infectious Diseases and Microbiology Laboratory Services, ICPMR, 3Marie Bashir Institute for Infectious Diseases and Biosecurity, The University of Sydney, 4Department of Microbiology and Infectious Diseases, Canberra Hospital and Health Services, Australian National University Medical School, 5Infection Management Services, Australian National University Medical School, 6Department of Microbiology and Infectious Diseases, St. Vincent's Hospital, 7Department of Infectious Diseases, Peter MacCallum Cancer Centre
* These authors contributed equally

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Denne undersøgelse gennemført hele genome sequencing for analyse af mutationer i gener, der giver svampedræbende resistens i Candida glabrata. C. glabrata isolater resistente over for echinocandins, azoles og 5-flucytosine, blev sekventeret for at illustrere metoden. Modtagelighed profiler af isolaterne korreleret med tilstedeværelse eller fravær af specifikke mutation mønstre i gener.

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Medicin spørgsmål 130 Candida glabrata hele genome sequencing svampedræbende medicinresistens echinocandins azoles 5-flucytosine genom-bred analyse
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