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Induction de Syndrome néphrotique chez la souris par Injection rétrooculaire de la doxorubicine et la prévention de la rétention de Volume par LIBERATION PROLONGEE aprotinine

Article DOI: 10.3791/57642-v • 07:38 min • May 6th, 2018
May 6th, 2018 •
1,2,3, 1,2,3
1Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Disease, Nephrology and Clinical Chemistry, University Hospital Tübingen, 2Institute of Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich, University Tübingen, 3German Center for Diabetes Research (DZD), University Tübingen

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Nous décrivons ici l’induction de syndrome néphrotique expérimental chez la souris 129S1/SvImJ par injection rapide rétrooculaire de la doxorubicine. Nous traitons également néphrotiques souris avec des boulettes de libération prolongée contenant aprotinine pour inhiber l’activité de la protéase sérine urinaire et prévenir la rétention sodée.

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Médecine question 135 syndrome néphrotique expérimental doxorubicine souris rétrooculaire aprotinine proteasuria
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