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JoVE Journal Behavior
Ein High-Performance Liquid Chromatography-Messung von Kynurenin und Kynurenic Säure
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Ein High-Performance Liquid Chromatography-Messung von Kynurenin und Kynurenic Säure: Biochemie zur Kognition und Schlaf bei Ratten

Article DOI: 10.3791/58129-v • 07:04 min • August 19th, 2018
August 19th, 2018 •
1, 2, 2, 1
1Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, 2Department of Pharmacology, University of Maryland School of Medicine

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Änderungen in den Kynurenin Weg (KP) neuroaktive Metaboliten sind in psychiatrischer Erkrankungen verwickelt. Untersuchung der funktionellen Ergebnisse einer veränderten Kynurenin Weg Stoffwechsel in Vivo bei Nagern kann helfen, neue therapeutische Ansätze zu erläutern. Das aktuelle Protokoll verbindet biochemischen und Verhaltensstörungen Ansätze zur Untersuchung der Auswirkungen einer akuten Kynurenin Herausforderung bei Ratten.

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Frage 138 Kynurenic Säure Kynurenin Verhalten Tryptophan Kognition Schlaf Verhalten Ratte EEG passive Vermeidung Hippocampus fluorometrisch HPLC
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