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患者源性肿瘤外植体作为预测患者耐药性的"实时"临床前平台
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Patient-Derived Tumor Explants As a “Live” Preclinical Platform for Predicting Drug Resistance in Patients
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患者源性肿瘤外植体作为预测患者耐药性的"实时"临床前平台

DOI:
10.3791/62130-v

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07:42 min

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February 07, 2021

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, , , , , , , , , , ,
1Leicester Cancer Research Center,University of Leicester, 2MRC Toxicology Unit

Capitoli

  • 00:04Introduction
  • 00:45Explant Preparation and Drug Treatment
  • 02:12Histological Processing
  • 03:09Training Analysis
  • 06:04Results: Representative Patient-Derived Explant Responses to Tumor Drugs of Interest
  • 07:02Conclusion

Summary

Traduzione automatica

Traduzione automatica

本文描述了在实时的、与患者相关的临床前模型系统中评估肿瘤药物反应的患者来源的外植体的生成、药物治疗和分析方法。

Tags

Patient-derived Tumor ExplantsPreclinical PlatformDrug Resistance Prediction3D Tumor ContextDrug ResponseDrug MetabolismPharmacodynamic BiomarkersOrganotypic CultureDrug TreatmentFormalin FixationHistological Processing

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