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Un modelo de rata Sprague Dawley de osteosarcoma ortotópico singénico con amputación para controlar la tasa de metástasis

Article DOI: 10.3791/62139-v • 07:31 min • May 3rd, 2021
May 3rd, 2021 •
1,2,3,4, 5, 1, 6, 7, 8, 9, 10, 4, 1,2
1Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, 2Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, 3Department of Surgery, Johns Hopkins University School of Medicine, 4Department of Coloproctological Surgery, Juntendo University Faculty of Medicine, 5Program for Comparative Medicine, Gene Therapy Program, Perelman School of Medicine, University of Pennsylvania, 6Tuskegee College of Veterinary Medicine, 7Department of Human Pathology, Juntendo University Faculty of Medicine, 8Department of Surgery, Juntendo University Shizuoka Hospital, Juntendo University School of Medicine, 9Department of Urology, The Johns Hopkins School of Medicine, 10Department of Gastroenterology and Minimally Invasive Surgery, Juntendo University Faculty of Medicine

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Aquí, se describe un implante ortotópico singénico seguido de un procedimiento de amputación del osteosarcoma con metástasis pulmonar espontánea que se puede utilizar para la investigación preclínica de la biología de la metástasis y el desarrollo de nuevas terapias.

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Cancer Research Número 171 sarcoma osteosarcoma implantación ortotópica modelo singénico de rata metástasis pulmonar amputación de piernas imágenes de rayos X
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