La Rete di Valutazione Preclinica dell'Ictus Modello Multilaboratorio dell'Ictus Tromboembolico con Trombolisi: TE-MCAo

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06:38 min.

19 dicembre 2025

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¹Department of Physiology and Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine of USC, ²Department of Neurosurgery, Keck School of Medicine of USC, ³Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, ⁴Department of Internal Medicine, Division of Hematology, Oncology and Blood & Marrow Transplantation, Carver College of Medicine, University of Iowa, ⁵Departments of Neurology & Neurosurgery, Carver College of Medicine, Department of Epidemiology, College of Public Health, University of Iowa, ⁶The Medical College of Georgia at Augusta University, ⁷Department of Anesthesiology, Duke University, ⁸University of California, San Diego, ⁹Department of Neurology, Yale University, ¹⁰Neurovascular Research Unit, Massachusetts General Hospital, ¹¹Laboratory of NeuroImaging, USC Mark and Mary Stevens Neuroimaging and Informatics Institute of the Keck School of Medicine of USC, ¹²Department of Neurology, Keck School of Medicine of USC

Per simulare l'ictus tromboembolico, sono stati iniettati emboli preparati con sangue di ratto eterologo nell'arteria cerebrale media, seguiti dalla somministrazione di trombolisi sistemica per la ricanalizzazione. Questa versione del modello è ottimizzata per l'uso in una rete multi-laboratorio e supporta il test di più candidati terapeutici.