脳卒中前臨床評価ネットワーク:血栓塞栓性脳卒中および血栓溶解症の多検査室モデル:TE-MCAo
932 回視聴
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06:38 分
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2025年12月19日
DOI :10.3791/69522-v
2025年12月19日
•932 回視聴
Mozammel Bhuiyan1 , Michelle Lin2 , Carly McCurry1 , Jessica Lamb1 , Marcio A. Diniz3 , Karni Bedirian3 , Anil Chauhan4 , Abhishek Jha4 , Aditi Jain4 , Enrique Leira5 , Mohammad B. Khan6 , Pradip K Kamat6 , David C Hess6 , Huaxin Sheng7 , Bingren Hu8 , Lauren H. Sansing9 , Cenk Ayata10 , Takahiko Imai10 , Kirsten Lynch11 , Patrick Lyden1,12
1Department of Physiology and Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine of USC, 2Department of Neurosurgery, Keck School of Medicine of USC, 3Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, 4Department of Internal Medicine, Division of Hematology, Oncology and Blood & Marrow Transplantation, Carver College of Medicine, University of Iowa, 5Departments of Neurology & Neurosurgery, Carver College of Medicine, Department of Epidemiology, College of Public Health, University of Iowa, 6The Medical College of Georgia at Augusta University, 7Department of Anesthesiology, Duke University, 8University of California, San Diego, 9Department of Neurology, Yale University, 10Neurovascular Research Unit, Massachusetts General Hospital, 11Laboratory of NeuroImaging, USC Mark and Mary Stevens Neuroimaging and Informatics Institute of the Keck School of Medicine of USC, 12Department of Neurology, Keck School of Medicine of USC
血栓塞栓性脳卒中を模擬するため、異種ラットの血液から調製した塞栓を中脳動脈に注入し、その後全身血栓溶解術を投与して再開化しました。このモデルのバージョンは、複数検査室ネットワークでの利用に最適化されており、複数の候補治療薬の試験をサポートしています。
Chapters in this video
0:00
Introduction
0:28
Femoral Artery Catheterization and Collection of Blood
2:59
Thrombus Preparation
5:10
Results
5:57
Conclusion
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