Benjamin A. Garcia Department of Biochemistry and Molecular Biophysics Washington University School of Medicine Biography Publications Institution JoVE Articles Benjamin A. Garcia has not added a biography. If you are Benjamin A. Garcia and would like to personalize this page please email our Author Liaison for assistance. Publications Phosphorylation Regulates Viral Biomolecular Condensates to Promote Infectious Progeny Production The EMBO Journal. Jan, 2024 | Pubmed ID: 38177504 Electrostatic Encoding of Genome Organization Principles Within Single Native Nucleosomes BioRxiv : the Preprint Server for Biology. Dec, 2023 | Pubmed ID: 38106048 The Antiproliferative Effect of FGF2 in K-Ras-driven Tumor Cells Involves Modulation of RRNA and the Nucleolus Journal of Cell Science. Nov, 2023 | Pubmed ID: 37921359 An Optimized and High-Throughput Method for Histone Propionylation and Data-Independent Acquisition Analysis for the Identification and Quantification of Histone Post-translational Modifications Journal of the American Society for Mass Spectrometry. Nov, 2023 | Pubmed ID: 37853520 Altered Chromatin Occupancy of Patient-associated H4 Mutants Misregulate Neuronal Differentiation BioRxiv : the Preprint Server for Biology. Sep, 2023 | Pubmed ID: 37808786 SWAMNA: a Comprehensive Platform for Analysis of Nucleic Acid Modifications Chemical Communications (Cambridge, England). Oct, 2023 | Pubmed ID: 37786919 Comparative Analysis of Drug-like EP300/CREBBP Acetyltransferase Inhibitors ACS Chemical Biology. Oct, 2023 | Pubmed ID: 37737090 Acetyl-methyllysine Marks Chromatin at Active Transcription Start Sites Nature. Oct, 2023 | Pubmed ID: 37731000 A Novel Brain PET Radiotracer for Imaging Alpha Synuclein Fibrils in Multiple System Atrophy Journal of Medicinal Chemistry. Sep, 2023 | Pubmed ID: 37651366 Comparative Analysis of Drug-like EP300/CREBBP Acetyltransferase Inhibitors BioRxiv : the Preprint Server for Biology. May, 2023 | Pubmed ID: 37292747 Alternative Splicing of HDAC7 Regulates Its Interaction with 14-3-3 Proteins to Alter Histone Marks and Target Gene Expression Cell Reports. Mar, 2023 | Pubmed ID: 36933216 Single Substitution in H3.3G34 Alters DNMT3A Recruitment to Cause Progressive Neurodegeneration Cell. Mar, 2023 | Pubmed ID: 36931244 Expanding the Epitranscriptomic RNA Sequencing and Modification Mapping Mass Spectrometry Toolbox with Field Asymmetric Waveform Ion Mobility and Electrochemical Elution Liquid Chromatography Analytical Chemistry. Mar, 2023 | Pubmed ID: 36916610 Characterizing Crosstalk in Epigenetic Signaling to Understand Disease Physiology The Biochemical Journal. Jan, 2023 | Pubmed ID: 36630129 Arginine Methylation of the PGC-1α C-Terminus Is Temperature-Dependent Biochemistry. Jan, 2023 | Pubmed ID: 36535003 Stable Isotope Tracing In vivo Reveals a Metabolic Bridge Linking the Microbiota to Host Histone Acetylation Cell Reports. Dec, 2022 | Pubmed ID: 36516747 K27M in Canonical and Noncanonical H3 Variants Occurs in Distinct Oligodendroglial Cell Lineages in Brain Midline Gliomas Nature Genetics. Dec, 2022 | Pubmed ID: 36471070 Combination of Common MtDNA Variants Results in Mitochondrial Dysfunction and a Connective Tissue Dysregulation Proceedings of the National Academy of Sciences of the United States of America. Nov, 2022 | Pubmed ID: 36322731 Top-"Double-Down" Mass Spectrometry of Histone H4 Proteoforms: Tandem Ultraviolet-Photon and Mobility/Mass-Selected Electron Capture Dissociations Analytical Chemistry. Nov, 2022 | Pubmed ID: 36282112 Nucleome Programming is Required for the Foundation of Totipotency in Mammalian Germline Development The EMBO Journal. Jul, 2022 | Pubmed ID: 35703121 Kabuki Syndrome Stem Cell Models Reveal Locus Specificity of Histone Methyltransferase 2D (KMT2D/MLL4) Human Molecular Genetics. Oct, 2022 | Pubmed ID: 35640156 Permethylation of Ribonucleosides Provides Enhanced Mass Spectrometry Quantification of Post-Transcriptional RNA Modifications Analytical Chemistry. May, 2022 | Pubmed ID: 35549217 H3K36 Dimethylation Shapes the Epigenetic Interaction Landscape by Directing Repressive Chromatin Modifications in Embryonic Stem Cells Genome Research. May, 2022 | Pubmed ID: 35396277 Data-Independent Acquisition for the Detection of Mononucleoside RNA Modifications by Mass Spectrometry Journal of the American Society for Mass Spectrometry. May, 2022 | Pubmed ID: 35357823 Multi-omic Profiling of Histone Variant H3.3 Lysine 27 Methylation Reveals a Distinct Role from Canonical H3 in Stem Cell Differentiation Molecular Omics. Jan, 2022 | Pubmed ID: 35044400 Interaction with the CCT Chaperonin Complex Limits APOBEC3A Cytidine Deaminase Cytotoxicity EMBO Reports. Sep, 2021 | Pubmed ID: 34347354 Human Chimeric Antigen Receptor Macrophages for Cancer Immunotherapy Nature Biotechnology. 08, 2020 | Pubmed ID: 32361713 Protein Kinase C Epsilon Is a Key Regulator of Mitochondrial Redox Homeostasis in Acute Myeloid Leukemia Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. 02, 2018 | Pubmed ID: 29127121 Histone H3K36 Mutations Promote Sarcomagenesis Through Altered Histone Methylation Landscape Science (New York, N.Y.). May, 2016 | Pubmed ID: 27174990 Inhibition of DHHC20-Mediated EGFR Palmitoylation Creates a Dependence on EGFR Signaling Molecular Cell. May, 2016 | Pubmed ID: 27153536 PRDM16 Suppresses MLL1r Leukemia Via Intrinsic Histone Methyltransferase Activity Molecular Cell. Apr, 2016 | Pubmed ID: 27151440 A Novel Quantitative Mass Spectrometry Platform for Determining Protein O-GlcNAcylation Dynamics Molecular & Cellular Proteomics : MCP. Apr, 2016 | Pubmed ID: 27114449 Folate Deficiency Affects Histone Methylation Medical Hypotheses. Mar, 2016 | Pubmed ID: 26880641 Histone H4 Acetylation and the Epigenetic Reader Brd4 Are Critical Regulators of Pluripotency in Embryonic Stem Cells BMC Genomics. 2016 | Pubmed ID: 26847871 Reshaping the Chromatin and Epigenetic Landscapes with Quantitative Mass Spectrometry Molecular & Cellular Proteomics : MCP. Mar, 2016 | Pubmed ID: 26814188 Bioorthogonal Chemistry for the Isolation and Study of Newly Synthesized Histones and Their Modifications ACS Chemical Biology. Mar, 2016 | Pubmed ID: 26789204 Analyses of Histone Proteoforms Using Front-end Electron Transfer Dissociation-enabled Orbitrap Instruments Molecular & Cellular Proteomics : MCP. Mar, 2016 | Pubmed ID: 26785730 Quantitative Profiling of the Activity of Protein Lysine Methyltransferase SMYD2 Using SILAC-Based Proteomics Molecular & Cellular Proteomics : MCP. Mar, 2016 | Pubmed ID: 26750096 Tet2 Catalyzes Stepwise 5-Methylcytosine Oxidation by an Iterative and De Novo Mechanism Journal of the American Chemical Society. Jan, 2016 | Pubmed ID: 26734843 Histone Modification Profiling Reveals Differential Signatures Associated with Human Embryonic Stem Cell Self-renewal and Differentiation Proteomics. Feb, 2016 | Pubmed ID: 26631989 Monitoring Cellular Phosphorylation Signaling Pathways into Chromatin and Down to the Gene Level Molecular & Cellular Proteomics : MCP. Mar, 2016 | Pubmed ID: 26543102 Loss of HP1 Causes Depletion of H3K27me3 from Facultative Heterochromatin and Gain of H3K27me2 at Constitutive Heterochromatin Genome Research. Jan, 2016 | Pubmed ID: 26537359 Permuting the PGF Signature Motif Blocks Both Archaeosortase-Dependent C-Terminal Cleavage and Prenyl Lipid Attachment for the Haloferax Volcanii S-Layer Glycoprotein Journal of Bacteriology. 2015 | Pubmed ID: 26712937 H4K44 Acetylation Facilitates Chromatin Accessibility During Meiosis Cell Reports. Dec, 2015 | Pubmed ID: 26628362 Nitric Oxide Regulates Gene Expression in Cancers by Controlling Histone Posttranslational Modifications Cancer Research. Dec, 2015 | Pubmed ID: 26542213 Tumour Exosome Integrins Determine Organotropic Metastasis Nature. Nov, 2015 | Pubmed ID: 26524530 Low Resolution Data-Independent Acquisition in an LTQ-Orbitrap Allows for Simplified and Fully Untargeted Analysis of Histone Modifications Analytical Chemistry. Nov, 2015 | Pubmed ID: 26505526 The PZP Domain of AF10 Senses Unmodified H3K27 to Regulate DOT1L-Mediated Methylation of H3K79 Molecular Cell. Oct, 2015 | Pubmed ID: 26439302 Progress in Epigenetic Histone Modification Analysis by Mass Spectrometry for Clinical Investigations Expert Review of Proteomics. 2015 | Pubmed ID: 26400466 The Histone Lysine Methyltransferase KMT2D Sustains a Gene Expression Program That Represses B Cell Lymphoma Development Nature Medicine. Oct, 2015 | Pubmed ID: 26366710 Comprehensive Catalog of Currently Documented Histone Modifications Cold Spring Harbor Perspectives in Biology. Sep, 2015 | Pubmed ID: 26330523 Analysis of Histones H3 and H4 Reveals Novel and Conserved Post-Translational Modifications in Sugarcane PloS One. 2015 | Pubmed ID: 26226299 Properly Reading the Histone Code by MS-based Proteomics Proteomics. Sep, 2015 | Pubmed ID: 26223514 Critical Role of Histone Turnover in Neuronal Transcription and Plasticity Neuron. Jul, 2015 | Pubmed ID: 26139371 Characterization of Histone Post-translational Modifications During Virus Infection Using Mass Spectrometry-based Proteomics Methods (San Diego, Calif.). Nov, 2015 | Pubmed ID: 26093074 Memory Acquisition and Retrieval Impact Different Epigenetic Processes That Regulate Gene Expression BMC Genomics. 2015 | Pubmed ID: 26040834 Multi-faceted Quantitative Proteomics Analysis of Histone H2B Isoforms and Their Modifications Epigenetics & Chromatin. 2015 | Pubmed ID: 25922622 Proteogenomics Analysis Reveals Specific Genomic Orientations of Distal Regulatory Regions Composed by Non-canonical Histone Variants Epigenetics & Chromatin. 2015 | Pubmed ID: 25878728 LLY-507, a Cell-active, Potent, and Selective Inhibitor of Protein-lysine Methyltransferase SMYD2 The Journal of Biological Chemistry. May, 2015 | Pubmed ID: 25825497 EpiProfile Quantifies Histone Peptides With Modifications by Extracting Retention Time and Intensity in High-resolution Mass Spectra Molecular & Cellular Proteomics : MCP. Jun, 2015 | Pubmed ID: 25805797 Bottom-up and Middle-down Proteomics Have Comparable Accuracies in Defining Histone Post-translational Modification Relative Abundance and Stoichiometry Analytical Chemistry. Mar, 2015 | Pubmed ID: 25719549 Characterization of BRD4 During Mammalian Postmeiotic Sperm Development Molecular and Cellular Biology. Apr, 2015 | Pubmed ID: 25691659 Quantitative Proteomic Analysis of Histone Modifications Chemical Reviews. Mar, 2015 | Pubmed ID: 25688442 A Specific LSD1/KDM1A Isoform Regulates Neuronal Differentiation Through H3K9 Demethylation Molecular Cell. Mar, 2015 | Pubmed ID: 25684206 Drawbacks in the Use of Unconventional Hydrophobic Anhydrides for Histone Derivatization in Bottom-up Proteomics PTM Analysis Proteomics. May, 2015 | Pubmed ID: 25641854 Sequential Window Acquisition of All Theoretical Mass Spectra (SWATH) Analysis for Characterization and Quantification of Histone Post-translational Modifications Molecular & Cellular Proteomics : MCP. Sep, 2015 | Pubmed ID: 25636311 The Cerebral Cavernous Malformation Pathway Controls Cardiac Development Via Regulation of Endocardial MEKK3 Signaling and KLF Expression Developmental Cell. Jan, 2015 | Pubmed ID: 25625206 Identification of Nuclear Hormone Receptor Pathways Causing Insulin Resistance by Transcriptional and Epigenomic Analysis Nature Cell Biology. Jan, 2015 | Pubmed ID: 25503565 Defining Heterochromatin in C. Elegans Through Genome-wide Analysis of the Heterochromatin Protein 1 Homolog HPL-2 Genome Research. Jan, 2015 | Pubmed ID: 25467431 Selective Inhibition of EZH2 and EZH1 Enzymatic Activity by a Small Molecule Suppresses MLL-rearranged Leukemia Blood. Jan, 2015 | Pubmed ID: 25395428 BRD4 Assists Elongation of Both Coding and Enhancer RNAs by Interacting with Acetylated Histones Nature Structural & Molecular Biology. Dec, 2014 | Pubmed ID: 25383670 Analytical Tools and Current Challenges in the Modern Era of Neuroepigenomics Nature Neuroscience. Nov, 2014 | Pubmed ID: 25349914 High Resolution is Not a Strict Requirement for Characterization and Quantification of Histone Post-translational Modifications Journal of Proteome Research. Dec, 2014 | Pubmed ID: 25325711 In Vivo Proximity Labeling for the Detection of Protein-protein and Protein-RNA Interactions Journal of Proteome Research. Dec, 2014 | Pubmed ID: 25311790 SnapShot: Histone Modifications Cell. Oct, 2014 | Pubmed ID: 25303536 Evaluation of Proteomic Search Engines for the Analysis of Histone Modifications Journal of Proteome Research. Oct, 2014 | Pubmed ID: 25167464 Histone Methylation Has Dynamics Distinct from Those of Histone Acetylation in Cell Cycle Reentry from Quiescence Molecular and Cellular Biology. Nov, 2014 | Pubmed ID: 25154414 A Proteomic Glimpse into the Initial Global Epigenetic Changes During HIV Infection Proteomics. Oct, 2014 | Pubmed ID: 25116026 Middle-Down and Top-Down Mass Spectrometric Analysis of Co-occurring Histone Modifications Current Protocols in Protein Science / Editorial Board, John E. Coligan ... [et Al.]. 2014 | Pubmed ID: 25081742 Stable-isotope-labeled Histone Peptide Library for Histone Post-translational Modification and Variant Quantification by Mass Spectrometry Molecular & Cellular Proteomics : MCP. Sep, 2014 | Pubmed ID: 25000943 Akt-dependent Metabolic Reprogramming Regulates Tumor Cell Histone Acetylation Cell Metabolism. Aug, 2014 | Pubmed ID: 24998913 Quantitative Proteomic Discovery of Dynamic Epigenome Changes That Control Human Cytomegalovirus (HCMV) Infection Molecular & Cellular Proteomics : MCP. Sep, 2014 | Pubmed ID: 24987098 Mass Spectrometric Analysis of Histone Proteoforms Annual Review of Analytical Chemistry (Palo Alto, Calif.). 2014 | Pubmed ID: 24896311 ChIP-less Analysis of Chromatin States Epigenetics & Chromatin. 2014 | Pubmed ID: 24872844 SMYD3 Links Lysine Methylation of MAP3K2 to Ras-driven Cancer Nature. Jun, 2014 | Pubmed ID: 24847881 De Novo Peptide Design and Experimental Validation of Histone Methyltransferase Inhibitors PloS One. 2014 | Pubmed ID: 24740276 De Novo Peptide Design and Experimental Validation of Histone Methyltransferase Inhibitors PloS One. 2014 | Pubmed ID: 24587223 Stable Isotope Labeling of Phosphoproteins for Large-scale Phosphorylation Rate Determination Molecular & Cellular Proteomics : MCP. Apr, 2014 | Pubmed ID: 24532841 Tyr Phosphorylation of PDP1 Toggles Recruitment Between ACAT1 and SIRT3 to Regulate the Pyruvate Dehydrogenase Complex Molecular Cell. Feb, 2014 | Pubmed ID: 24486017 Neutron-encoded Mass Signatures for Quantitative Top-down Proteomics Analytical Chemistry. Mar, 2014 | Pubmed ID: 24475910 Identification and Interrogation of Combinatorial Histone Modifications Frontiers in Genetics. 2013 | Pubmed ID: 24391660 Proteomic Analysis of the SIRT6 Interactome: Novel Links to Genome Maintenance and Cellular Stress Signaling Scientific Reports. 2013 | Pubmed ID: 24169447 H3R42me2a is a Histone Modification with Positive Transcriptional Effects Proceedings of the National Academy of Sciences of the United States of America. Sep, 2013 | Pubmed ID: 23980157 Initial Characterization of Histone H3 Serine 10 O-acetylation Epigenetics. Oct, 2013 | Pubmed ID: 23949383 H4K20 Methylation Regulates Quiescence and Chromatin Compaction Molecular Biology of the Cell. Oct, 2013 | Pubmed ID: 23924899 Proteomic Characterization of Novel Histone Post-translational Modifications Epigenetics & Chromatin. 2013 | Pubmed ID: 23916056 Combining Genomic and Proteomic Approaches for Epigenetics Research Epigenomics. Aug, 2013 | Pubmed ID: 23895656 A Quantitative Atlas of Histone Modification Signatures from Human Cancer Cells Epigenetics & Chromatin. 2013 | Pubmed ID: 23826629 Dysregulation of PAD4-mediated Citrullination of Nuclear GSK3β Activates TGF-β Signaling and Induces Epithelial-to-mesenchymal Transition in Breast Cancer Cells Proceedings of the National Academy of Sciences of the United States of America. Jul, 2013 | Pubmed ID: 23818587 Proteomic and Genomic Approaches Reveal Critical Functions of H3K9 Methylation and Heterochromatin Protein-1γ in Reprogramming to Pluripotency Nature Cell Biology. Jul, 2013 | Pubmed ID: 23748610 Large-scale Global Identification of Protein Lysine Methylation in Vivo Epigenetics. May, 2013 | Pubmed ID: 23644510 Retraction: Branched Tricarboxylic Acid Metabolism in Plasmodium Falciparum Nature. May, 2013 | Pubmed ID: 23615611 Inhibition of PRC2 Activity by a Gain-of-function H3 Mutation Found in Pediatric Glioblastoma Science (New York, N.Y.). May, 2013 | Pubmed ID: 23539183 Quantitative Dynamics of the Link Between Cellular Metabolism and Histone Acetylation The Journal of Biological Chemistry. Apr, 2013 | Pubmed ID: 23482559 Heavy Methyl-SILAC Labeling Coupled with Liquid Chromatography and High-resolution Mass Spectrometry to Study the Dynamics of Site-specific Histone Methylation Methods in Molecular Biology (Clifton, N.J.). 2013 | Pubmed ID: 23436372 Validation of Protein Acetylation by Mass Spectrometry Methods in Molecular Biology (Clifton, N.J.). 2013 | Pubmed ID: 23381849 Comprehending Dynamic Protein Methylation with Mass Spectrometry Current Opinion in Chemical Biology. Feb, 2013 | Pubmed ID: 23333572 SETD6 Monomethylates H2AZ on Lysine 7 and is Required for the Maintenance of Embryonic Stem Cell Self-renewal Epigenetics. Feb, 2013 | Pubmed ID: 23324626 Chromatin Proteins Captured by ChIP-mass Spectrometry Are Linked to Dosage Compensation in Drosophila Nature Structural & Molecular Biology. Feb, 2013 | Pubmed ID: 23295261 Scoperta Di Combinazioni Di Biomarker Che Predire La Salute Parodontale O Malattia Con Alta Esattezza Da GCF Campioni Basato Su High-throughput Proteomic Analysis E Mixed Integer Ottimizzazione Lineare Journal of Clinical Periodontology. Oct, 2012 | Pubmed ID: 23190455 Siti Di Fosforilazione Romanzo in S. Cerevisiae Cdc13 Proteina Rivelano Nuovi Obiettivi Per Il Regolamento Di Lunghezza Telomeri Journal of Proteome Research. Nov, 2012 | Pubmed ID: 23181431 Asymmetrically Modified Nucleosomes Cell. Sep, 2012 | Pubmed ID: 23021224 Examining Histone Posttranslational Modification Patterns by High-resolution Mass Spectrometry Methods in Enzymology. 2012 | Pubmed ID: 22910200 Proteogenomic Characterization and Mapping of Nucleosomes Decoded by Brd and HP1 Proteins Genome Biology. 2012 | Pubmed ID: 22897906 PILOT_PROTEIN: Identificazione Delle Proteine Non Modificate E Modificate Tramite Spettrometria Di Massa Ad Alta Risoluzione E Ottimizzazione Lineari Misto-interi Journal of Proteome Research. Sep, 2012 | Pubmed ID: 22788846 Poly-acetylated Chromatin Signatures Are Preferred Epitopes for Site-specific Histone H4 Acetyl Antibodies Scientific Reports. 2012 | Pubmed ID: 22761995 SIRT7 Links H3K18 Deacetylation to Maintenance of Oncogenic Transformation Nature. Jul, 2012 | Pubmed ID: 22722849 Discovery of Lysine Post-translational Modifications Through Mass Spectrometric Detection Essays in Biochemistry. 2012 | Pubmed ID: 22708569 Global Secretome Analysis Identifies Novel Mediators of Bone Metastasis Cell Research. Sep, 2012 | Pubmed ID: 22688892 BclAF1 Restriction Factor is Neutralized by Proteasomal Degradation and MicroRNA Repression During Human Cytomegalovirus Infection Proceedings of the National Academy of Sciences of the United States of America. Jun, 2012 | Pubmed ID: 22645331 Melanoma Exosomes Educate Bone Marrow Progenitor Cells Toward a Pro-metastatic Phenotype Through MET Nature Medicine. Jun, 2012 | Pubmed ID: 22635005 H3K4 Demetilazione Di Jarid1a E Jarid1b Contribuisce Al Silenziamento Genico Mediato Da Retinoblastoma Durante La Senescenza Cellulare Proceedings of the National Academy of Sciences of the United States of America. Jun, 2012 | Pubmed ID: 22615382 Origins and Formation of Histone Methylation Across the Human Cell Cycle Molecular and Cellular Biology. Jul, 2012 | Pubmed ID: 22547680 Smyd3 Regulates Cancer Cell Phenotypes and Catalyzes Histone H4 Lysine 5 Methylation Epigenetics. Apr, 2012 | Pubmed ID: 22419068 ATRX-mediated Chromatin Association of Histone Variant MacroH2A1 Regulates α-globin Expression Genes & Development. Mar, 2012 | Pubmed ID: 22391447 Histone H3 Lysine 56 Methylation Regulates DNA Replication Through Its Interaction with PCNA Molecular Cell. Apr, 2012 | Pubmed ID: 22387026 Methylation of H4 Lysines 5, 8 and 12 by Yeast Set5 Calibrates Chromatin Stress Responses Nature Structural & Molecular Biology. Mar, 2012 | Pubmed ID: 22343720 Novel Protein Identification Methods for Biomarker Discovery Via a Proteomic Analysis of Periodontally Healthy and Diseased Gingival Crevicular Fluid Samples Journal of Clinical Periodontology. Mar, 2012 | Pubmed ID: 22092770 NSD2 Link Dimethylation Dell'istone H3 a Lisina 36 a Oncogenica Di Programmazione Molecular Cell. Nov, 2011 | Pubmed ID: 22099308 Breaking the Histone Code with Quantitative Mass Spectrometry Expert Review of Proteomics. Oct, 2011 | Pubmed ID: 21999833 Quantitative Proteomic Approaches to Studying Histone Modifications Current Chemical Genomics. 2011 | Pubmed ID: 21966350 Proteomic Interrogation of Human Chromatin PloS One. 2011 | Pubmed ID: 21935452 Direct Targeting of Sec23a by MiR-200s Influences Cancer Cell Secretome and Promotes Metastatic Colonization Nature Medicine. Sep, 2011 | Pubmed ID: 21822286 Methylation of H2AR29 is a Novel Repressive PRMT6 Target Epigenetics & Chromatin. 2011 | Pubmed ID: 21774791 Una Sonda Chimica Inibisce Selettivamente L'attività Di Metiltransferasi G9a E GLP Nelle Cellule Nature Chemical Biology. Aug, 2011 | Pubmed ID: 21743462 The RING Finger Protein MSL2 in the MOF Complex is an E3 Ubiquitin Ligase for H2B K34 and is Involved in Crosstalk with H3 K4 and K79 Methylation Molecular Cell. Jul, 2011 | Pubmed ID: 21726816 Histone Deacetylase 9 Deficiency Protects Against Effector T Cell-mediated Systemic Autoimmunity The Journal of Biological Chemistry. Aug, 2011 | Pubmed ID: 21708950 Revealing Histone Variant Induced Changes Via Quantitative Proteomics Critical Reviews in Biochemistry and Molecular Biology. Aug, 2011 | Pubmed ID: 21526979 Isoform-specific Phosphorylation of Human Linker Histone H1.4 in Mitosis by the Kinase Aurora B Journal of Cell Science. May, 2011 | Pubmed ID: 21511733 Lysine Methylation of the NF-κB Subunit RelA by SETD6 Couples Activity of the Histone Methyltransferase GLP at Chromatin to Tonic Repression of NF-κB Signaling Nature Immunology. Jan, 2011 | Pubmed ID: 21131967 Proteomics Journal of Biomedicine & Biotechnology. 2010 | Pubmed ID: 21541239 The Histone Variant MacroH2A Suppresses Melanoma Progression Through Regulation of CDK8 Nature. Dec, 2010 | Pubmed ID: 21179167 Global Turnover of Histone Post-translational Modifications and Variants in Human Cells Epigenetics & Chromatin. 2010 | Pubmed ID: 21134274 Trimethylation of Histone H3 Lysine 4 Impairs Methylation of Histone H3 Lysine 9: Regulation of Lysine Methyltransferases by Physical Interaction with Their Substrates Epigenetics. Nov-Dec, 2010 | Pubmed ID: 21124070 Branched Tricarboxylic Acid Metabolism in Plasmodium Falciparum Nature. Aug, 2010 | Pubmed ID: 20686576 The Significance, Development and Progress of High-throughput Combinatorial Histone Code Analysis Cellular and Molecular Life Sciences : CMLS. Dec, 2010 | Pubmed ID: 20683756 Histone H4K20/H3K9 Demethylase PHF8 Regulates Zebrafish Brain and Craniofacial Development Nature. Jul, 2010 | Pubmed ID: 20622853 Quantitative Proteomics Reveals Direct and Indirect Alterations in the Histone Code Following Methyltransferase Knockdown Molecular BioSystems. Sep, 2010 | Pubmed ID: 20577673 Histone H1 Variant-specific Lysine Methylation by G9a/KMT1C and Glp1/KMT1D Epigenetics & Chromatin. 2010 | Pubmed ID: 20334638 Collective Mass Spectrometry Approaches Reveal Broad and Combinatorial Modification of High Mobility Group Protein A1a Journal of the American Society for Mass Spectrometry. Jun, 2010 | Pubmed ID: 20202861 Combinatorial Profiling of Chromatin Binding Modules Reveals Multisite Discrimination Nature Chemical Biology. Apr, 2010 | Pubmed ID: 20190764 Systems-wide Proteomic Characterization of Combinatorial Post-translational Modification Patterns Expert Review of Proteomics. Feb, 2010 | Pubmed ID: 20121478 Modern Approaches for Investigating Epigenetic Signaling Pathways Journal of Applied Physiology (Bethesda, Md. : 1985). Sep, 2010 | Pubmed ID: 20110548 A Novel Approach for Untargeted Post-translational Modification Identification Using Integer Linear Optimization and Tandem Mass Spectrometry Molecular & Cellular Proteomics : MCP. May, 2010 | Pubmed ID: 20103568 What Does the Future Hold for Top Down Mass Spectrometry? Journal of the American Society for Mass Spectrometry. Feb, 2010 | Pubmed ID: 19942451 In Vivo Residue-specific Histone Methylation Dynamics The Journal of Biological Chemistry. Jan, 2010 | Pubmed ID: 19940157 Electron Transfer Dissociation Facilitates Sequencing of Adenosine Diphosphate-ribosylated Peptides Analytical Chemistry. Jan, 2010 | Pubmed ID: 19928949 One-pot Shotgun Quantitative Mass Spectrometry Characterization of Histones Journal of Proteome Research. Nov, 2009 | Pubmed ID: 19764812 Protein Quantification Across Hundreds of Experimental Conditions Proceedings of the National Academy of Sciences of the United States of America. Sep, 2009 | Pubmed ID: 19717460 A Mixed Integer Linear Optimization Framework for the Identification and Quantification of Targeted Post-translational Modifications of Highly Modified Proteins Using Multiplexed Electron Transfer Dissociation Tandem Mass Spectrometry Molecular & Cellular Proteomics : MCP. Nov, 2009 | Pubmed ID: 19666874 Tutto Il Proteoma Previsione Dei Substrati Di Acetilazione Proceedings of the National Academy of Sciences of the United States of America. Aug, 2009 | Pubmed ID: 19666589 High Throughput Characterization of Combinatorial Histone Codes Molecular & Cellular Proteomics : MCP. Oct, 2009 | Pubmed ID: 19654425 Heterochromatin Protein 1 is Extensively Decorated with Histone Code-like Post-translational Modifications Molecular & Cellular Proteomics : MCP. Nov, 2009 | Pubmed ID: 19567367 Mass Spectrometric Analysis of Histone Variants and Post-translational Modifications Frontiers in Bioscience (Scholar Edition). 2009 | Pubmed ID: 19482690 Histone H3 Lysine 56 Acetylation is Linked to the Core Transcriptional Network in Human Embryonic Stem Cells Molecular Cell. Feb, 2009 | Pubmed ID: 19250903 Chromatin-specific Remodeling by HMGB1 and Linker Histone H1 Silences Proinflammatory Genes During Endotoxin Tolerance Molecular and Cellular Biology. Apr, 2009 | Pubmed ID: 19158276 Tandem Mass Spectrometry with Ultrahigh Mass Accuracy Clarifies Peptide Identification by Database Retrieval Journal of Proteome Research. Jan, 2009 | Pubmed ID: 19053528 Analysis of Histones in Xenopus Laevis. II. Mass Spectrometry Reveals an Index of Cell Type-specific Modifications on H3 and H4 The Journal of Biological Chemistry. Jan, 2009 | Pubmed ID: 18957437 Cathepsin L Proteolytically Processes Histone H3 During Mouse Embryonic Stem Cell Differentiation Cell. Oct, 2008 | Pubmed ID: 18957203 Tissue-specific Expression and Post-translational Modification of Histone H3 Variants Journal of Proteome Research. Oct, 2008 | Pubmed ID: 18700791 Mild Performic Acid Oxidation Enhances Chromatographic and Top Down Mass Spectrometric Analyses of Histones Molecular & Cellular Proteomics : MCP. Sep, 2007 | Pubmed ID: 17569892 Pervasive Combinatorial Modification of Histone H3 in Human Cells Nature Methods. Jun, 2007 | Pubmed ID: 17529979 Chemical Derivatization of Histones for Facilitated Analysis by Mass Spectrometry Nature Protocols. 2007 | Pubmed ID: 17446892 Fosfatasi Della Proteina 1 Regola Assieme E La Funzione Della Degradazione Di Beta-catenina Complessa The EMBO Journal. Mar, 2007 | Pubmed ID: 17318175 Organismal Differenze in Traslazionali in Istoni H3 E H4 The Journal of Biological Chemistry. Mar, 2007 | Pubmed ID: 17194708 Identificazione Di Acetilazione Lisina 36 Istone H3 Come Una Modifica Dell'istone Altamente Conservata The Journal of Biological Chemistry. Mar, 2007 | Pubmed ID: 17189264 Characterization of Histones and Their Post-translational Modifications by Mass Spectrometry Current Opinion in Chemical Biology. Feb, 2007 | Pubmed ID: 17157550 Un Percorso Di Deacetylase Dell'istone Romanzo Regola Mitosi Modulando L'attività Della Chinasi Aurora B Genes & Development. Sep, 2006 | Pubmed ID: 16980585 Protein Profile of Osteoarthritic Human Articular Cartilage Using Tandem Mass Spectrometry Rapid Communications in Mass Spectrometry : RCM. 2006 | Pubmed ID: 16969770 Site-specific Casein Kinase 1epsilon-dependent Phosphorylation of Dishevelled Modulates Beta-catenin Signaling The FEBS Journal. Oct, 2006 | Pubmed ID: 16965538 Analisi Completa Della Fosfoproteina Dell'istone Di Linker H1 Da Tetrahymena Thermophila Molecular & Cellular Proteomics : MCP. Sep, 2006 | Pubmed ID: 16835217 Negative Regulation of LRP6 Function by Casein Kinase I Epsilon Phosphorylation The Journal of Biological Chemistry. May, 2006 | Pubmed ID: 16513652 Expression Patterns and Post-translational Modifications Associated with Mammalian Histone H3 Variants The Journal of Biological Chemistry. Jan, 2006 | Pubmed ID: 16267050 Resetting the Epigenetic Histone Code in the MRL-lpr/lpr Mouse Model of Lupus by Histone Deacetylase Inhibition Journal of Proteome Research. Nov-Dec, 2005 | Pubmed ID: 16335948 Regulation of HP1-chromatin Binding by Histone H3 Methylation and Phosphorylation Nature. Dec, 2005 | Pubmed ID: 16222246 Il Proteoma Piastrinico Di Microparticelle Journal of Proteome Research. Sep-Oct, 2005 | Pubmed ID: 16212402 Modifications of Human Histone H3 Variants During Mitosis Biochemistry. Oct, 2005 | Pubmed ID: 16185088 Serine 31 Phosphorylation of Histone Variant H3.3 is Specific to Regions Bordering Centromeres in Metaphase Chromosomes Proceedings of the National Academy of Sciences of the United States of America. May, 2005 | Pubmed ID: 15851689 Analysis of Protein Phosphorylation by Mass Spectrometry Methods (San Diego, Calif.). Mar, 2005 | Pubmed ID: 15722222 Simian Virus 40 Small T Antigen Mediates Conformation-dependent Transfer of Protein Phosphatase 2A Onto the Androgen Receptor Molecular and Cellular Biology. Feb, 2005 | Pubmed ID: 15684382 Mass Spectrometry Analysis of Arabidopsis Histone H3 Reveals Distinct Combinations of Post-translational Modifications Nucleic Acids Research. 2004 | Pubmed ID: 15598823 Characterization of Phosphorylation Sites on Histone H1 Isoforms by Tandem Mass Spectrometry Journal of Proteome Research. Nov-Dec, 2004 | Pubmed ID: 15595731 Improvement of the MALDI-TOF Analysis of DNA with Thin-layer Matrix Preparation Analytical Chemistry. May, 2002 | Pubmed ID: 12033310 Improvement in the Apparent Mass Resolution of Oligonucleotides by Using 12C/14N-enriched Samples Analytical Chemistry. Jan, 2002 | Pubmed ID: 11795798 Author Spotlight: Enhanced Histone PTM Isomer Identification Through LC-TIMS-ToF MS/MS and PASEF Meiby Fernandez-Rojas1, Cassandra N. Fuller1, Lilian Valadares Tose1, Matthew Willetts2, Melvin A. Park2, Natarajan V. Bhanu3, Benjamin A. Garcia3, Francisco Fernandez-Lima1,4 1Department of Chemistry and Biochemistry, Florida International University, 2Bruker Daltonics Inc., 3Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, 4Biomolecular Sciences Institute, Florida International University JoVE 65589 화학 Preparazione dei campioni per l'identificazione basati sulla spettrometria di massa di RNA-binding Regions Robert Warneford-Thomson1,4, Chongsheng He1,2, Simone Sidoli1,3, Benjamin A. Garcia1,3, Roberto Bonasio1,2 1Epigenetics Institute, University of Pennsylvania Perelman School of Medicine, 2Department of Cell and Developmental Biology, University of Pennsylvania Perelman School of Medicine, 3Department of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, 4Graduate Group in Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine JoVE 56004 생화학 Flusso di lavoro completo per l'analisi dell'istone modificazioni post-traduzionali Utilizzando Bottom-up Spettrometria di Massa: Da istone estrazione all'analisi dei dati Simone Sidoli1, Natarajan V. Bhanu1, Kelly R. Karch1, Xiaoshi Wang1, Benjamin A. Garcia1 1Epigenetics Program, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania JoVE 54112 생물학
Author Spotlight: Enhanced Histone PTM Isomer Identification Through LC-TIMS-ToF MS/MS and PASEF Meiby Fernandez-Rojas1, Cassandra N. Fuller1, Lilian Valadares Tose1, Matthew Willetts2, Melvin A. Park2, Natarajan V. Bhanu3, Benjamin A. Garcia3, Francisco Fernandez-Lima1,4 1Department of Chemistry and Biochemistry, Florida International University, 2Bruker Daltonics Inc., 3Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, 4Biomolecular Sciences Institute, Florida International University JoVE 65589 화학
Preparazione dei campioni per l'identificazione basati sulla spettrometria di massa di RNA-binding Regions Robert Warneford-Thomson1,4, Chongsheng He1,2, Simone Sidoli1,3, Benjamin A. Garcia1,3, Roberto Bonasio1,2 1Epigenetics Institute, University of Pennsylvania Perelman School of Medicine, 2Department of Cell and Developmental Biology, University of Pennsylvania Perelman School of Medicine, 3Department of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, 4Graduate Group in Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine JoVE 56004 생화학
Flusso di lavoro completo per l'analisi dell'istone modificazioni post-traduzionali Utilizzando Bottom-up Spettrometria di Massa: Da istone estrazione all'analisi dei dati Simone Sidoli1, Natarajan V. Bhanu1, Kelly R. Karch1, Xiaoshi Wang1, Benjamin A. Garcia1 1Epigenetics Program, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania JoVE 54112 생물학
