Christopher C. W. Hughes

Publications

• A Human Vascularized Microtumor Model of Patient-derived Colorectal Cancer Recapitulates Clinical Disease
  Translational Research : the Journal of Laboratory and Clinical Medicine. May, 2023  |   Pubmed ID: 36481562
• Organotypic Stromal Cells Impact Endothelial Cell Transcriptome in 3D Microvessel Networks
  Scientific Reports. Nov, 2022  |   Pubmed ID: 36443378
• Adoptive T-Cell Therapy in Advanced Colorectal Cancer: A Systematic Review
  The Oncologist. Mar, 2022  |   Pubmed ID: 35274719
• Correction: The Vascular Niche in Next Generation Microphysiological Systems
  Lab on a Chip. Sep, 2021  |   Pubmed ID: 34472547
• The Vascular Niche in Next Generation Microphysiological Systems
  Lab on a Chip. Sep, 2021  |   Pubmed ID: 34396383
• An in Vitro Vascularized Micro-tumor Model of Human Colorectal Cancer Recapitulates in Vivo Responses to Standard-of-care Therapy
  Lab on a Chip. Apr, 2021  |   Pubmed ID: 33605955
• Slug Regulates the Dll4-Notch-VEGFR2 Axis to Control Endothelial Cell Activation and Angiogenesis
  Nature Communications. Oct, 2020  |   Pubmed ID: 33106502
• Induction of Mesoderm and Neural Crest-Derived Pericytes from Human Pluripotent Stem Cells to Study Blood-Brain Barrier Interactions
  Stem Cell Reports. Mar, 2019  |   Pubmed ID: 30745035
• Pazopanib May Reduce Bleeding in Hereditary Hemorrhagic Telangiectasia
  Angiogenesis. Feb, 2019  |   Pubmed ID: 30191360
• Executive Summary of the 12th HHT International Scientific Conference
  Angiogenesis. Feb, 2018  |   Pubmed ID: 29147802
• 3D Anastomosed Microvascular Network Model with Living Capillary Networks and Endothelial Cell-Lined Microfluidic Channels
  Methods in Molecular Biology (Clifton, N.J.). 2017  |   Pubmed ID: 28634954
• A Vascularized and Perfused Organ-on-a-chip Platform for Large-scale Drug Screening Applications
  Lab on a Chip. Jan, 2017  |   Pubmed ID: 28092382
• Recapitulating the Human Tumor Microenvironment: Colon Tumor-derived Extracellular Matrix Promotes Angiogenesis and Tumor Cell Growth
  Biomaterials. Feb, 2017  |   Pubmed ID: 27914984
• MTORC2 Mediates CXCL12-induced Angiogenesis
  Angiogenesis. Jul, 2016  |   Pubmed ID: 27106789
• Engineering Anastomosis Between Living Capillary Networks and Endothelial Cell-lined Microfluidic Channels
  Lab on a Chip. Jan, 2016  |   Pubmed ID: 26616908
• Executive Summary of the 11th HHT International Scientific Conference
  Angiogenesis. Oct, 2015  |   Pubmed ID: 26391603
• A Role for Partial Endothelial-mesenchymal Transitions in Angiogenesis?
  Arteriosclerosis, Thrombosis, and Vascular Biology. Feb, 2015  |   Pubmed ID: 25425619
• Interferon-induced Transmembrane Protein 1 Regulates Endothelial Lumen Formation During Angiogenesis
  Arteriosclerosis, Thrombosis, and Vascular Biology. May, 2014  |   Pubmed ID: 24603679
• Angiogenic Sprouting is Regulated by Endothelial Cell Expression of Slug
  Journal of Cell Science. May, 2014  |   Pubmed ID: 24554431
• Analysis of Stromal Cell Secretomes Reveals a Critical Role for Stromal Cell-derived Hepatocyte Growth Factor and Fibronectin in Angiogenesis
  Arteriosclerosis, Thrombosis, and Vascular Biology. Mar, 2013  |   Pubmed ID: 23288153
• Macrophages and Angiogenesis: a Role for Wnt Signaling
  Vascular Cell. 2012  |   Pubmed ID: 22938389
• BMP9 Induces EphrinB2 Expression in Endothelial Cells Through an Alk1-BMPRII/ActRII-ID1/ID3-dependent Pathway: Implications for Hereditary Hemorrhagic Telangiectasia Type II
  Angiogenesis. Sep, 2012  |   Pubmed ID: 22622516
• Integration of the Beta-catenin-dependent Wnt Pathway with Integrin Signaling Through the Adaptor Molecule Grb2
  PloS One. 2009  |   Pubmed ID: 19924227
• TNF Induction of Jagged-1 in Endothelial Cells is NFkappaB-dependent
  Gene. Apr, 2009  |   Pubmed ID: 19393188
• Prevascularization of a Fibrin-based Tissue Construct Accelerates the Formation of Functional Anastomosis with Host Vasculature
  Tissue Engineering. Part A. Jun, 2009  |   Pubmed ID: 18976155
• An Optimized Three-dimensional in Vitro Model for the Analysis of Angiogenesis
  Methods in Enzymology. 2008  |   Pubmed ID: 18772011
• Endothelial-stromal Interactions in Angiogenesis
  Current Opinion in Hematology. May, 2008  |   Pubmed ID: 18391786
• Wnt Signaling Induces Matrix Metalloproteinase Expression and Regulates T Cell Transmigration
  Immunity. Feb, 2007  |   Pubmed ID: 17306568
• Mesenchymal Stem Cells Enhance Angiogenesis in Mechanically Viable Prevascularized Tissues Via Early Matrix Metalloproteinase Upregulation
  Tissue Engineering. Oct, 2006  |   Pubmed ID: 17518656
• HESR1/CHF2 Suppresses VEGFR2 Transcription Independent of Binding to E-boxes
  Biochemical and Biophysical Research Communications. Aug, 2006  |   Pubmed ID: 16782059
• Cell-autonomous Notch Signaling Regulates Endothelial Cell Branching and Proliferation During Vascular Tubulogenesis
  FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jun, 2005  |   Pubmed ID: 15774577
• VEGF(121) and VEGF(165) Regulate Blood Vessel Diameter Through Vascular Endothelial Growth Factor Receptor 2 in an in Vitro Angiogenesis Model
  Laboratory Investigation; a Journal of Technical Methods and Pathology. Dec, 2003  |   Pubmed ID: 14691306
• Notch Activation During Endothelial Cell Network Formation in Vitro Targets the Basic HLH Transcription Factor HESR-1 and Downregulates VEGFR-2/KDR Expression
  Microvascular Research. Nov, 2002  |   Pubmed ID: 12453432