David Margulies Department of Organic Chemistry Weizmann Institute of Science Biography Publications Institution JoVE Articles David Margulies has not added a biography. If you are David Margulies and would like to personalize this page please email our Author Liaison for assistance. Publications Genetic Misdiagnoses and the Potential for Health Disparities The New England Journal of Medicine. Aug, 2016 | Pubmed ID: 27532831 Lipopolysaccharide-Induced CD300b Receptor Binding to Toll-like Receptor 4 Alters Signaling to Drive Cytokine Responses That Enhance Septic Shock Immunity. Jun, 2016 | Pubmed ID: 27261276 Message in a Molecule Nature Communications. 2016 | Pubmed ID: 27138465 Orthogonal NGS for High Throughput Clinical Diagnostics Scientific Reports. 2016 | Pubmed ID: 27090146 Interaction of TAPBPR, a Tapasin Homolog, with MHC-I Molecules Promotes Peptide Editing Proceedings of the National Academy of Sciences of the United States of America. Feb, 2016 | Pubmed ID: 26869717 Prevalence and Treatment Outcomes of Persistent Negative Mood Among Children with Attention-Deficit/Hyperactivity Disorder and Aggressive Behavior Journal of Child and Adolescent Psychopharmacology. Mar, 2016 | Pubmed ID: 26745211 Gene Expression Analysis in Fmr1KO Mice Identifies an Immunological Signature in Brain Tissue and MGluR5-related Signaling in Primary Neuronal Cultures Molecular Autism. 2015 | Pubmed ID: 26697163 William E. Paul 1936-2015 Nature Immunology. Dec, 2015 | Pubmed ID: 26580498 Artificial Signal Transduction Therapy: a Futuristic Approach to Disease Treatment Future Medicinal Chemistry. Oct, 2015 | Pubmed ID: 26510968 A Novel MHC-I Surface Targeted for Binding by the MCMV M06 Immunoevasin Revealed by Solution NMR The Journal of Biological Chemistry. Nov, 2015 | Pubmed ID: 26463211 Sensing Protein Surfaces with Targeted Fluorescent Receptors Chemistry (Weinheim an Der Bergstrasse, Germany). Nov, 2015 | Pubmed ID: 26398521 Sensing Protein Surfaces with Targeted Fluorescent Receptors Chemistry (Weinheim an Der Bergstrasse, Germany). Nov, 2015 | Pubmed ID: 26382918 The Neuronal Migration Factor SrGAP2 Achieves Specificity in Ligand Binding Through a Two-Component Molecular Mechanism Structure (London, England : 1993). Nov, 2015 | Pubmed ID: 26365803 Protein-Protein Communication and Enzyme Activation Mediated by a Synthetic Chemical Transducer Journal of the American Chemical Society. Aug, 2015 | Pubmed ID: 25955617 The Cellular Environment Regulates in Situ Kinetics of T-cell Receptor Interaction with Peptide Major Histocompatibility Complex European Journal of Immunology. Jul, 2015 | Pubmed ID: 25944482 Enzyme-Artificial Enzyme Interactions As a Means for Discriminating Among Structurally Similar Isozymes Journal of the American Chemical Society. Apr, 2015 | Pubmed ID: 25819325 The Structure of Mouse Cytomegalovirus M04 Protein Obtained from Sparse NMR Data Reveals a Conserved Fold of the M02-m06 Viral Immune Modulator Family Structure (London, England : 1993). Sep, 2014 | Pubmed ID: 25126960 The In-betweeners: MAIT Cells Join the Innate-like Lymphocytes Gang The Journal of Experimental Medicine. Jul, 2014 | Pubmed ID: 25071161 Targeted Protein Surface Sensors As a Tool for Analyzing Small Populations of Proteins in Biological Mixtures Angewandte Chemie (International Ed. in English). Aug, 2014 | Pubmed ID: 24841443 An International Effort Towards Developing Standards for Best Practices in Analysis, Interpretation and Reporting of Clinical Genome Sequencing Results in the CLARITY Challenge Genome Biology. 2014 | Pubmed ID: 24667040 IPSC-derived Neurons As a Higher-throughput Readout for Autism: Promises and Pitfalls Trends in Molecular Medicine. Feb, 2014 | Pubmed ID: 24374161 Development of a Scalable Pharmacogenomic Clinical Decision Support Service AMIA Joint Summits on Translational Science Proceedings. AMIA Joint Summits on Translational Science. 2013 | Pubmed ID: 24303299 Callous-unemotional Traits, Proactive Aggression, and Treatment Outcomes of Aggressive Children with Attention-deficit/hyperactivity Disorder Journal of the American Academy of Child and Adolescent Psychiatry. Dec, 2013 | Pubmed ID: 24290461 Mutation of KCNJ8 in a Patient with Cantú Syndrome with Unique Vascular Abnormalities - Support for the Role of K(ATP) Channels in This Condition European Journal of Medical Genetics. Dec, 2013 | Pubmed ID: 24176758 Authorizing Multiple Chemical Passwords by a Combinatorial Molecular Keypad Lock Journal of the American Chemical Society. Oct, 2013 | Pubmed ID: 24088016 A Structural and Molecular Dynamics Approach to Understanding the Peptide-receptive Transition State of MHC-I Molecules Molecular Immunology. Sep, 2013 | Pubmed ID: 23200143 Structural Basis of Mouse Cytomegalovirus M152/gp40 Interaction with RAE1γ Reveals a Paradigm for MHC/MHC Interaction in Immune Evasion Proceedings of the National Academy of Sciences of the United States of America. Dec, 2012 | Pubmed ID: 23169621 Medication Detection by a Combinatorial Fluorescent Molecular Sensor Angewandte Chemie (International Ed. in English). Dec, 2012 | Pubmed ID: 23065749 The Peptide-receptive Transition State of MHC Class I Molecules: Insight from Structure and Molecular Dynamics Journal of Immunology (Baltimore, Md. : 1950). Aug, 2012 | Pubmed ID: 22753930 Will Disruptive Mood Dysregulation Disorder Reduce False Diagnosis of Bipolar Disorder in Children? Bipolar Disorders. Aug, 2012 | Pubmed ID: 22713098 Abacavir Induces Loading of Novel Self-peptides into HLA-B*57: 01: an Autoimmune Model for HLA-associated Drug Hypersensitivity AIDS (London, England). Jul, 2012 | Pubmed ID: 22617051 High-throughput Sequencing of MGluR Signaling Pathway Genes Reveals Enrichment of Rare Variants in Autism PloS One. 2012 | Pubmed ID: 22558107 Chimeric Anti-staphylococcal Enterotoxin B Antibodies and Lovastatin Act Synergistically to Provide in Vivo Protection Against Lethal Doses of SEB PloS One. 2011 | Pubmed ID: 22102880 How the Virus Outsmarts the Host: Function and Structure of Cytomegalovirus MHC-I-like Molecules in the Evasion of Natural Killer Cell Surveillance Journal of Biomedicine & Biotechnology. 2011 | Pubmed ID: 21765638 Counterpoint: Do Not Opine Before It's Time Nature Biotechnology. Mar, 2011 | Pubmed ID: 21390023 Combinatorial Protein Recognition As an Alternative Approach to Antibody-mimetics Current Opinion in Chemical Biology. Dec, 2010 | Pubmed ID: 20829097 Liquid Risperidone in the Treatment of Rages in Psychiatrically Hospitalized Children with Possible Bipolar Disorder Bipolar Disorders. Mar, 2010 | Pubmed ID: 20402713 Potent Neutralization of Staphylococcal Enterotoxin B by Synergistic Action of Chimeric Antibodies Infection and Immunity. Jun, 2010 | Pubmed ID: 20308304 Direct Interaction of the Mouse Cytomegalovirus M152/gp40 Immunoevasin with RAE-1 Isoforms Biochemistry. Mar, 2010 | Pubmed ID: 20166740 Surface Binding Inhibitors of the SCF-KIT Protein-protein Interaction Chembiochem : a European Journal of Chemical Biology. Aug, 2009 | Pubmed ID: 19637142 Structural Basis of the CD8 Alpha Beta/MHC Class I Interaction: Focused Recognition Orients CD8 Beta to a T Cell Proximal Position Journal of Immunology (Baltimore, Md. : 1950). Aug, 2009 | Pubmed ID: 19625641 Different Vaccine Vectors Delivering the Same Antigen Elicit CD8+ T Cell Responses with Distinct Clonotype and Epitope Specificity Journal of Immunology (Baltimore, Md. : 1950). Aug, 2009 | Pubmed ID: 19620307 Rages or Temper Tantrums? The Behavioral Organization, Temporal Characteristics, and Clinical Significance of Angry-agitated Outbursts in Child Psychiatry Inpatients Child Psychiatry and Human Development. Dec, 2009 | Pubmed ID: 19568928 Digital Analysis of Protein Properties by an Ensemble of DNA Quadruplexes Journal of the American Chemical Society. Jul, 2009 | Pubmed ID: 19566086 Rages--what Are They and Who Has Them? Journal of Child and Adolescent Psychopharmacology. Jun, 2009 | Pubmed ID: 19519263 Antigen-processing and Presentation Pathways Select Antigenic HIV Peptides in the Fight Against Viral Evolution Nature Immunology. Jun, 2009 | Pubmed ID: 19448656 A Single Residue, Arginine 65, is Critical for the Functional Interaction of Leukocyte-associated Inhibitory Receptor-1 with Collagens Journal of Immunology (Baltimore, Md. : 1950). May, 2009 | Pubmed ID: 19380792 Home Schooling of NK Cells Immunity. Mar, 2009 | Pubmed ID: 19303382 The Behavioral Organization, Temporal Characteristics, and Diagnostic Concomitants of Rage Outbursts in Child Psychiatric Inpatients Current Psychiatry Reports. Apr, 2009 | Pubmed ID: 19302766 Protein Recognition by an Ensemble of Fluorescent DNA G-quadruplexes Angewandte Chemie (International Ed. in English). 2009 | Pubmed ID: 19173368 Structure and Function of Murine Cytomegalovirus MHC-I-like Molecules: How the Virus Turned the Host Defense to Its Advantage Immunologic Research. 2009 | Pubmed ID: 19011767 Availability of Autoantigenic Epitopes Controls Phenotype, Severity, and Penetrance in TCR Tg Autoimmune Gastritis European Journal of Immunology. Dec, 2008 | Pubmed ID: 19039784 Estimation of Low Frequency Antigen-presenting Cells with a Novel RELISPOT Assay Journal of Immunological Methods. Apr, 2008 | Pubmed ID: 18294650 The TLR3 Signaling Complex Forms by Cooperative Receptor Dimerization Proceedings of the National Academy of Sciences of the United States of America. Jan, 2008 | Pubmed ID: 18172197 Role of Alpha3 Domain of Class I MHC Molecules in the Activation of High- and Low-avidity CD8+ CTLs International Immunology. Dec, 2007 | Pubmed ID: 17981793 Cellular Expression and Crystal Structure of the Murine Cytomegalovirus Major Histocompatibility Complex Class I-like Glycoprotein, M153 The Journal of Biological Chemistry. Nov, 2007 | Pubmed ID: 17897947 Avidity of CD8 T Cells Sharpens Immunodominance International Immunology. Apr, 2007 | Pubmed ID: 17376783 A Molecular Keypad Lock: a Photochemical Device Capable of Authorizing Password Entries Journal of the American Chemical Society. Jan, 2007 | Pubmed ID: 17212414 A Molecular Full-adder and Full-subtractor, an Additional Step Toward a Moleculator Journal of the American Chemical Society. Apr, 2006 | Pubmed ID: 16594723 Crystal Structure of the Murine Cytomegalovirus MHC-I Homolog M144 Journal of Molecular Biology. Apr, 2006 | Pubmed ID: 16500675 Fluorescein As a Model Molecular Calculator with Reset Capability Nature Materials. Oct, 2005 | Pubmed ID: 16155575 Backbone and Side Chain Resonance Assignmentsof a TRAV14-3 Mouse T Cell Receptor Domain Journal of Biomolecular NMR. Mar, 2005 | Pubmed ID: 15803407 Monoclonal Antibodies: Producing Magic Bullets by Somatic Cell Hybridization Journal of Immunology (Baltimore, Md. : 1950). Mar, 2005 | Pubmed ID: 15728445 Chemical Input Multiplicity Facilitates Arithmetical Processing Journal of the American Chemical Society. Dec, 2004 | Pubmed ID: 15563165 Resistance to Viral Infection by Intraepithelial Lymphocytes in HIV-1 P18-I10-specific T-cell Receptor Transgenic Mice Biochemical and Biophysical Research Communications. Apr, 2004 | Pubmed ID: 15020225 Spontaneous Organ-specific Th2-mediated Autoimmunity in TCR Transgenic Mice Journal of Immunology (Baltimore, Md. : 1950). Mar, 2004 | Pubmed ID: 14978094 Molecular Interactions: Stiff or Floppy (or Somewhere in Between?) Immunity. Dec, 2003 | Pubmed ID: 14670294 Variable MHC Class I Engagement by Ly49 Natural Killer Cell Receptors Demonstrated by the Crystal Structure of Ly49C Bound to H-2K(b) Nature Immunology. Dec, 2003 | Pubmed ID: 14595439 Magnetic Tuning of Biquadratic Exchange Coupling in Magnetic Thin Films Physical Review Letters. Aug, 2003 | Pubmed ID: 14525207 CD28, Costimulator or Agonist Receptor? The Journal of Experimental Medicine. Apr, 2003 | Pubmed ID: 12707298 A Serine/threonine Phosphorylation Site in the Ectodomain of a T Cell Receptor Beta Chain is Required for Activation by Superantigen Journal of Receptor and Signal Transduction Research. Feb, 2003 | Pubmed ID: 12680588 Rapid Induction of Apoptosis in CD8+ HIV-1 Envelope-specific Murine CTLs by Short Exposure to Antigenic Peptide Journal of Immunology (Baltimore, Md. : 1950). Dec, 2002 | Pubmed ID: 12444171 Bidentate Ligation of Heme Analogues; Novel Biomimetics of Peroxidase Active Site Chemistry (Weinheim an Der Bergstrasse, Germany). Sep, 2002 | Pubmed ID: 12360943 Crystal Structure of the Ly49I Natural Killer Cell Receptor Reveals Variability in Dimerization Mode Within the Ly49 Family Journal of Molecular Biology. Jul, 2002 | Pubmed ID: 12096910 MHC Class I Recognition by Ly49 Natural Killer Cell Receptors Molecular Immunology. May, 2002 | Pubmed ID: 11955594 Structure and Function of Natural Killer Cell Receptors: Multiple Molecular Solutions to Self, Nonself Discrimination Annual Review of Immunology. 2002 | Pubmed ID: 11861620 Binding of the Natural Killer Cell Inhibitory Receptor Ly49A to Its Major Histocompatibility Complex Class I Ligand. Crucial Contacts Include Both H-2Dd AND Beta 2-microglobulin The Journal of Biological Chemistry. Jan, 2002 | Pubmed ID: 11696552 संकेतन प्रोटीन के समारोह की नक़ल करना: की ओर कृत्रिम संकेत पारगमन थेरेपी Ronny Peri-Naor1, Leila Motiei1, David Margulies1 1Department of Organic Chemistry, Weizmann Institute of Science 생화학
संकेतन प्रोटीन के समारोह की नक़ल करना: की ओर कृत्रिम संकेत पारगमन थेरेपी Ronny Peri-Naor1, Leila Motiei1, David Margulies1 1Department of Organic Chemistry, Weizmann Institute of Science 생화학