Guri Giaever Donnelly Centre for Cellular and Biomolecular Research University of Toronto Biography Publications Institution JoVE Articles Guri Giaever has not added a biography. If you are Guri Giaever and would like to personalize this page please email our Author Liaison for assistance. Publications Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles ACS Central Science. Oct, 2016 | Pubmed ID: 27800551 Genome-wide RNAi Analysis Reveals That Simultaneous Inhibition of Specific Mevalonate Pathway Genes Potentiates Tumor Cell Death Oncotarget. Sep, 2015 | Pubmed ID: 26353928 Caenorhabditis Elegans is a Useful Model for Anthelmintic Discovery Nature Communications. Jun, 2015 | Pubmed ID: 26108372 Genes Required for Survival in Microgravity Revealed by Genome-wide Yeast Deletion Collections Cultured During Spaceflight BioMed Research International. 2015 | Pubmed ID: 25667933 A Genome Scale Overexpression Screen to Reveal Drug Activity in Human Cells Genome Medicine. 2014 | Pubmed ID: 24944581 Mapping the Cellular Response to Small Molecules Using Chemogenomic Fitness Signatures Science (New York, N.Y.). Apr, 2014 | Pubmed ID: 24723613 Large-scale Identification and Analysis of Suppressive Drug Interactions Chemistry & Biology. Apr, 2014 | Pubmed ID: 24704506 PITPs As Targets for Selectively Interfering with Phosphoinositide Signaling in Cells Nature Chemical Biology. Jan, 2014 | Pubmed ID: 24292071 A Novel Small Molecule Methyltransferase is Important for Virulence in Candida Albicans ACS Chemical Biology. Dec, 2013 | Pubmed ID: 24083538 Miniature Short Hairpin RNA Screens to Characterize Antiproliferative Drugs G3 (Bethesda, Md.). Aug, 2013 | Pubmed ID: 23797109 A High-throughput Yeast Assay Identifies Synergistic Drug Combinations Assay and Drug Development Technologies. Jun, 2013 | Pubmed ID: 23772551 DNA-damaging Agents in Cancer Chemotherapy: Serendipity and Chemical Biology Chemistry & Biology. May, 2013 | Pubmed ID: 23706631 Global Analysis of SUMO Chain Function Reveals Multiple Roles in Chromatin Regulation The Journal of Cell Biology. Apr, 2013 | Pubmed ID: 23547032 Lysosomal Disruption Preferentially Targets Acute Myeloid Leukemia Cells and Progenitors The Journal of Clinical Investigation. Jan, 2013 | Pubmed ID: 23202731 Chromatin is an Ancient Innovation Conserved Between Archaea and Eukarya ELife. Dec, 2012 | Pubmed ID: 23240084 A Phenotypic Screening Platform to Identify Small Molecule Modulators of Chlamydomonas Reinhardtii Growth, Motility and Photosynthesis Genome Biology. Nov, 2012 | Pubmed ID: 23158586 Functional Analysis with a Barcoder Yeast Gene Overexpression System G3 (Bethesda, Md.). Oct, 2012 | Pubmed ID: 23050238 Genome-wide Analysis of Intracellular PH Reveals Quantitative Control of Cell Division Rate by PH(c) in Saccharomyces Cerevisiae Genome Biology. Sep, 2012 | Pubmed ID: 23021432 An Algorithm for Chemical Genomic Profiling That Minimizes Batch Effects: Bucket Evaluations BMC Bioinformatics. Sep, 2012 | Pubmed ID: 23009392 Global Gene Deletion Analysis Exploring Yeast Filamentous Growth Science (New York, N.Y.). Sep, 2012 | Pubmed ID: 22984072 Comparative Chemogenomics to Examine the Mechanism of Action of Dna-targeted Platinum-acridine Anticancer Agents ACS Chemical Biology. Nov, 2012 | Pubmed ID: 22928710 Barcode Sequencing for Understanding Drug-gene Interactions Methods in Molecular Biology (Clifton, N.J.). 2012 | Pubmed ID: 22821592 A Novel Calcineurin-independent Activity of Cyclosporin A in Saccharomyces Cerevisiae Molecular BioSystems. Aug, 2012 | Pubmed ID: 22751784 Identification of Yeast Genes That Confer Resistance to Chitosan Oligosaccharide (COS) Using Chemogenomics BMC Genomics. Jun, 2012 | Pubmed ID: 22727066 Dafadine Inhibits DAF-9 to Promote Dauer Formation and Longevity of Caenorhabditis Elegans Nature Chemical Biology. 2012 | Pubmed ID: 22337098 Mitochondrial Electron Transport is the Cellular Target of the Oncology Drug Elesclomol PloS One. 2012 | Pubmed ID: 22253786 Bugs, Drugs and Chemical Genomics Nature Chemical Biology. Jan, 2012 | Pubmed ID: 22173359 A Global Perspective of the Genetic Basis for Carbonyl Stress Resistance G3 (Bethesda, Md.). Aug, 2011 | Pubmed ID: 22384333 Multiple Means to the Same End: the Genetic Basis of Acquired Stress Resistance in Yeast PLoS Genetics. Nov, 2011 | Pubmed ID: 22102822 Inhibition of Mitochondrial Translation As a Therapeutic Strategy for Human Acute Myeloid Leukemia Cancer Cell. Nov, 2011 | Pubmed ID: 22094260 Systematic Exploration of Synergistic Drug Pairs Molecular Systems Biology. 2011 | Pubmed ID: 22068327 Dafadine Inhibits DAF-9 to Promote Dauer Formation and Longevity of Caenorhabditis Elegans Nature Chemical Biology. Dec, 2011 | Pubmed ID: 22057127 Compound Prioritization Methods Increase Rates of Chemical Probe Discovery in Model Organisms Chemistry & Biology. Oct, 2011 | Pubmed ID: 22035796 A Systems Biology Approach Reveals the Role of a Novel Methyltransferase in Response to Chemical Stress and Lipid Homeostasis PLoS Genetics. Oct, 2011 | Pubmed ID: 22028670 Curcumin Inhibits Growth of Saccharomyces Cerevisiae Through Iron Chelation Eukaryotic Cell. Nov, 2011 | Pubmed ID: 21908599 Displaying Chemical Information on a Biological Network Using Cytoscape Methods in Molecular Biology (Clifton, N.J.). 2011 | Pubmed ID: 21877291 The Automated Cell: Compound and Environment Screening System (ACCESS) for Chemogenomic Screening Methods in Molecular Biology (Clifton, N.J.). 2011 | Pubmed ID: 21863492 New Azole Antifungal Agents with Novel Modes of Action: Synthesis and Biological Studies of New Tridentate Ligands Based on Pyrazole and Triazole European Journal of Medicinal Chemistry. Sep, 2011 | Pubmed ID: 21723647 Design, Synthesis and Characterization of a Highly Effective Inhibitor for Analog-sensitive (as) Kinases PloS One. 2011 | Pubmed ID: 21698101 Design, Synthesis, and Characterization of a Highly Effective Hog1 Inhibitor: a Powerful Tool for Analyzing MAP Kinase Signaling in Yeast PloS One. 2011 | Pubmed ID: 21655328 Dosage Suppression Genetic Interaction Networks Enhance Functional Wiring Diagrams of the Cell Nature Biotechnology. Jun, 2011 | Pubmed ID: 21572441 A Comprehensive Platform for Highly Multiplexed Mammalian Functional Genetic Screens BMC Genomics. 2011 | Pubmed ID: 21548937 The Synthetic Genetic Interaction Network Reveals Small Molecules That Target Specific Pathways in Sacchromyces Cerevisiae Molecular BioSystems. Jun, 2011 | Pubmed ID: 21487606 Systematic Exploration of Essential Yeast Gene Function with Temperature-sensitive Mutants Nature Biotechnology. Apr, 2011 | Pubmed ID: 21441928 Knocking out Multigene Redundancies Via Cycles of Sexual Assortment and Fluorescence Selection Nature Methods. Feb, 2011 | Pubmed ID: 21217751 Gene Annotation and Drug Target Discovery in Candida Albicans with a Tagged Transposon Mutant Collection PLoS Pathogens. 2010 | Pubmed ID: 20949076 Exploring Gene Function and Drug Action Using Chemogenomic Dosage Assays Methods in Enzymology. 2010 | Pubmed ID: 20946813 Genome-wide Screen in Saccharomyces Cerevisiae Identifies Vacuolar Protein Sorting, Autophagy, Biosynthetic, and TRNA Methylation Genes Involved in Life Span Regulation PLoS Genetics. Jul, 2010 | Pubmed ID: 20657825 A Survey of Yeast Genomic Assays for Drug and Target Discovery Pharmacology & Therapeutics. Aug, 2010 | Pubmed ID: 20546776 A Predictive Model for Drug Bioaccumulation and Bioactivity in Caenorhabditis Elegans Nature Chemical Biology. Jul, 2010 | Pubmed ID: 20512140 A Universal TagModule Collection for Parallel Genetic Analysis of Microorganisms Nucleic Acids Research. Aug, 2010 | Pubmed ID: 20494978 Highly-multiplexed Barcode Sequencing: an Efficient Method for Parallel Analysis of Pooled Samples Nucleic Acids Research. Jul, 2010 | Pubmed ID: 20460461 Genotype to Phenotype: a Complex Problem Science (New York, N.Y.). Apr, 2010 | Pubmed ID: 20413493 Systematic Analysis of Genome-wide Fitness Data in Yeast Reveals Novel Gene Function and Drug Action Genome Biology. 2010 | Pubmed ID: 20226027 The Genetic Landscape of a Cell Science (New York, N.Y.). Jan, 2010 | Pubmed ID: 20093466 A Comparative Analysis of DNA Barcode Microarray Feature Size BMC Genomics. 2009 | Pubmed ID: 19825181 Quantitative Phenotyping Via Deep Barcode Sequencing Genome Research. Oct, 2009 | Pubmed ID: 19622793 Chemogenomic Approaches to Elucidation of Gene Function and Genetic Pathways Methods in Molecular Biology (Clifton, N.J.). 2009 | Pubmed ID: 19521822 A Molecular Barcoded Yeast ORF Library Enables Mode-of-action Analysis of Bioactive Compounds Nature Biotechnology. Apr, 2009 | Pubmed ID: 19349972 Precise Gene-dose Alleles for Chemical Genetics Genetics. Jun, 2009 | Pubmed ID: 19332878 Novel Insights into Iron Metabolism by Integrating Deletome and Transcriptome Analysis in an Iron Deficiency Model of the Yeast Saccharomyces Cerevisiae BMC Genomics. 2009 | Pubmed ID: 19321002 Computationally Driven, Quantitative Experiments Discover Genes Required for Mitochondrial Biogenesis PLoS Genetics. Mar, 2009 | Pubmed ID: 19300474 Knocking Sense into Regulatory Pathways Nature Biotechnology. Feb, 2009 | Pubmed ID: 19204694 Combining Chemical Genomics Screens in Yeast to Reveal Spectrum of Effects of Chemical Inhibition of Sphingolipid Biosynthesis BMC Microbiology. 2009 | Pubmed ID: 19144191 Chemical-genetic Profiling of Imidazo[1,2-a]pyridines and -pyrimidines Reveals Target Pathways Conserved Between Yeast and Human Cells PLoS Genetics. Nov, 2008 | Pubmed ID: 19043571 Combination Chemical Genetics Nature Chemical Biology. Nov, 2008 | Pubmed ID: 18936752 Yeast Chemical Genomics and Drug Discovery: an Update Trends in Pharmacological Sciences. Oct, 2008 | Pubmed ID: 18755517 Off-target Effects of Psychoactive Drugs Revealed by Genome-wide Assays in Yeast PLoS Genetics. 2008 | Pubmed ID: 18688276 Yeast Barcoders: a Chemogenomic Application of a Universal Donor-strain Collection Carrying Bar-code Identifiers Nature Methods. Aug, 2008 | Pubmed ID: 18622398 An Integrated Platform of Genomic Assays Reveals Small-molecule Bioactivities Nature Chemical Biology. Aug, 2008 | Pubmed ID: 18622389 The Extensive and Condition-dependent Nature of Epistasis Among Whole-genome Duplicates in Yeast Genome Research. Jul, 2008 | Pubmed ID: 18463300 Identification of Small Molecule Inhibitors of Pseudomonas Aeruginosa Exoenzyme S Using a Yeast Phenotypic Screen PLoS Genetics. Feb, 2008 | Pubmed ID: 18454192 The Chemical Genomic Portrait of Yeast: Uncovering a Phenotype for All Genes Science (New York, N.Y.). Apr, 2008 | Pubmed ID: 18420932 Chemical-genetic Approaches for Exploring the Mode of Action of Natural Products Progress in Drug Research. Fortschritte Der Arzneimittelforschung. Progrès Des Recherches Pharmaceutiques. 2008 | Pubmed ID: 18416308 Defining Genetic Interaction Proceedings of the National Academy of Sciences of the United States of America. Mar, 2008 | Pubmed ID: 18305163 Identification of Genes Involved in the Toxic Response of Saccharomyces Cerevisiae Against Iron and Copper Overload by Parallel Analysis of Deletion Mutants Toxicological Sciences : an Official Journal of the Society of Toxicology. Jan, 2008 | Pubmed ID: 17785683 Genome-wide Analysis of Barcoded Saccharomyces Cerevisiae Gene-deletion Mutants in Pooled Cultures Nature Protocols. 2007 | Pubmed ID: 18007632 Examining Protein Protein Interactions Using Endogenously Tagged Yeast Arrays: the Cross-and-capture System Genome Research. Dec, 2007 | Pubmed ID: 17989249 Accelerating the Discovery of Biologically Active Small Molecules Using a High-throughput Yeast Halo Assay Journal of Natural Products. Mar, 2007 | Pubmed ID: 17291044 Systematic Pathway Analysis Using High-resolution Fitness Profiling of Combinatorial Gene Deletions Nature Genetics. Feb, 2007 | Pubmed ID: 17206143 Chemical Genomic Profiling for Identifying Intracellular Targets of Toxicants Producing Parkinson's Disease Toxicological Sciences : an Official Journal of the Society of Toxicology. Jan, 2007 | Pubmed ID: 17043098 Experimental Approaches to Identify Genetic Networks Current Opinion in Biotechnology. Oct, 2006 | Pubmed ID: 16962766 A Unique and Universal Molecular Barcode Array Nature Methods. Aug, 2006 | Pubmed ID: 16862133 Genome-wide Requirements for Resistance to Functionally Distinct DNA-damaging Agents PLoS Genetics. Aug, 2005 | Pubmed ID: 16121259 A Latent Variable Model for Chemogenomic Profiling Bioinformatics (Oxford, England). Aug, 2005 | Pubmed ID: 15919724 Functional Genomic Analysis of the Rates of Protein Evolution Proceedings of the National Academy of Sciences of the United States of America. Apr, 2005 | Pubmed ID: 15800036 Mechanisms of Haploinsufficiency Revealed by Genome-wide Profiling in Yeast Genetics. Apr, 2005 | Pubmed ID: 15716499 Noise Minimization in Eukaryotic Gene Expression PLoS Biology. Jun, 2004 | Pubmed ID: 15124029 Chemogenomic Profiling: Identifying the Functional Interactions of Small Molecules in Yeast Proceedings of the National Academy of Sciences of the United States of America. Jan, 2004 | Pubmed ID: 14718668 A Chemical Genomics Approach to Understanding Drug Action Trends in Pharmacological Sciences. Sep, 2003 | Pubmed ID: 12967766 "Chemogenomics: Tools for Protein Families" and "Chemical Genomics: Chemical and Biological Integration" Pharmacogenomics. Jan, 2003 | Pubmed ID: 12517281 Functional Profiling of the Saccharomyces Cerevisiae Genome Nature. Jul, 2002 | Pubmed ID: 12140549 Systematic Screen for Human Disease Genes in Yeast Nature Genetics. Aug, 2002 | Pubmed ID: 12134146 Transcriptional Response of Saccharomyces Cerevisiae to DNA-damaging Agents Does Not Identify the Genes That Protect Against These Agents Proceedings of the National Academy of Sciences of the United States of America. Jun, 2002 | Pubmed ID: 12077312 Competitive Genomic Screens of Barcoded Yeast Libraries Andrew M. Smith*1,2, Tanja Durbic*2,3, Julia Oh*4, Malene Urbanus1,2, Michael Proctor5, Lawrence E. Heisler2,3, Guri Giaever2,6, Corey Nislow1,2,3 1Banting and Best Department of Medical Research and Department of Molecular Genetics, University of Toronto, 2Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 3Donnelly Sequencing Centre, University of Toronto, 4Genetics and Molecular Biology Branch, National Human Genome Research Institute, NIH, 5Stanford Genome Technology Center, Stanford School of Medicine, Stanford University, 6Department of Pharmaceutical Sciences, University of Toronto JoVE 2864 생물학
Competitive Genomic Screens of Barcoded Yeast Libraries Andrew M. Smith*1,2, Tanja Durbic*2,3, Julia Oh*4, Malene Urbanus1,2, Michael Proctor5, Lawrence E. Heisler2,3, Guri Giaever2,6, Corey Nislow1,2,3 1Banting and Best Department of Medical Research and Department of Molecular Genetics, University of Toronto, 2Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 3Donnelly Sequencing Centre, University of Toronto, 4Genetics and Molecular Biology Branch, National Human Genome Research Institute, NIH, 5Stanford Genome Technology Center, Stanford School of Medicine, Stanford University, 6Department of Pharmaceutical Sciences, University of Toronto JoVE 2864 생물학