Guy A. Rutter Department of Metabolism, Digestion and Reproduction, Faculty of Medicine Cell Biology and Functional Genomics Biography Publications Institution JoVE Articles Guy A. Rutter has not added a biography. If you are Guy A. Rutter and would like to personalize this page please email our Author Liaison for assistance. Publications Proinflammatory Cytokines, but Not Glucolipotoxicity, Suppress Nonsense-Mediated RNA Decay to Impair Regulated Transcript Isoform Processing in Pancreatic β-Cells BioRxiv : the Preprint Server for Biology. Dec, 2023 | Pubmed ID: 38187722 Paired Box 6 Gene Delivery Preserves Beta Cells and Improves Islet Transplantation Efficacy EMBO Molecular Medicine. Dec, 2023 | Pubmed ID: 37933577 Multiple Genetic Variants at the Locus Affect Local Super-enhancer Activity and Influence Pancreatic β-cell Survival and Function BioRxiv : the Preprint Server for Biology. Oct, 2023 | Pubmed ID: 37502937 Islet Autoimmunity in Human Type 1 Diabetes: Initiation and Progression from the Perspective of the Beta Cell Diabetologia. Nov, 2023 | Pubmed ID: 37488322 Impact of an Loss-of-function Variant on the Pancreatic Distribution of Zinc and Manganese: Laser Ablation-ICP-MS and Positron Emission Tomography Studies in Mice Frontiers in Endocrinology. 2023 | Pubmed ID: 37396167 Mitochondrial Metabolism and Dynamics in Pancreatic Beta Cell Glucose Sensing The Biochemical Journal. Jun, 2023 | Pubmed ID: 37284792 Identification of Biomarkers for Glycaemic Deterioration in Type 2 Diabetes Nature Communications. May, 2023 | Pubmed ID: 37137910 Divergent Acute Versus Prolonged Pharmacological GLP-1R Responses in Adult β Cell-specific β-arrestin 2 Knockout Mice Science Advances. May, 2023 | Pubmed ID: 37134170 Control of Human Pancreatic Beta Cell Kinome by Glucagon-like Peptide-1 Receptor Biased Agonism Diabetes, Obesity & Metabolism. Aug, 2023 | Pubmed ID: 37039251 Impact of COVID-19 During Pregnancy on Placental Pathology, Maternal and Neonatal Outcome - A Cross-sectional Study on Anemic Term Pregnant Women from a Tertiary Care Hospital in Southern India Frontiers in Endocrinology. 2023 | Pubmed ID: 37025411 Molecular Phenotyping of Single Pancreatic Islet Leader Beta Cells by "Flash-Seq" Life Sciences. Mar, 2023 | Pubmed ID: 36706832 A Novel Somatic Mutation Implicates ATP6V0D1 in Proinsulin Processing Journal of the Endocrine Society. Jan, 2023 | Pubmed ID: 36694809 New-onset Type 1 Diabetes and Severe Acute Respiratory Syndrome Coronavirus 2 Infection Immunology and Cell Biology. Mar, 2023 | Pubmed ID: 36529987 Vertical Sleeve Gastrectomy Normalizes Circulating Glucocorticoid Levels and Lowers Glucocorticoid Action Tissue-selectively in Mice Frontiers in Endocrinology. 2022 | Pubmed ID: 36246869 Human Alpha Cell Transcriptomic Signatures of Types 1 and 2 Diabetes Highlight Disease-specific Dysfunction Pathways IScience. Oct, 2022 | Pubmed ID: 36134336 Homocysteine Metabolism Pathway Is Involved in the Control of Glucose Homeostasis: A Cystathionine Beta Synthase Deficiency Study in Mouse Cells. May, 2022 | Pubmed ID: 35681432 In Vivo and in Vitro Characterization of GL0034, a Novel Long-acting Glucagon-like Peptide-1 Receptor Agonist Diabetes, Obesity & Metabolism. Nov, 2022 | Pubmed ID: 35676825 DRP1 Levels Determine the Apoptotic Threshold During Embryonic Differentiation Through a Mitophagy-dependent Mechanism Developmental Cell. Jun, 2022 | Pubmed ID: 35597240 Vertical Sleeve Gastrectomy Lowers SGLT2/Slc5a2 Expression in the Mouse Kidney Diabetes. Aug, 2022 | Pubmed ID: 35594379 Glucose-Dependent MiR-125b Is a Negative Regulator of β-Cell Function Diabetes. Jul, 2022 | Pubmed ID: 35476777 Mitofusins Mfn1 and Mfn2 Are Required to Preserve Glucose- but Not Incretin-Stimulated β-Cell Connectivity and Insulin Secretion Diabetes. Jul, 2022 | Pubmed ID: 35472764 Autotaxin Signaling Facilitates β Cell Dedifferentiation and Dysfunction Induced by Sirtuin 3 Deficiency Molecular Metabolism. Jun, 2022 | Pubmed ID: 35398277 Opposing Effects on Regulated Insulin Secretion of Acute Vs Chronic Stimulation of AMP-activated Protein Kinase Diabetologia. Jun, 2022 | Pubmed ID: 35294578 Destabilization of β Cell FIT2 by Saturated Fatty Acids Alter Lipid Droplet Numbers and Contribute to ER Stress and Diabetes Proceedings of the National Academy of Sciences of the United States of America. Mar, 2022 | Pubmed ID: 35254894 Lack of ZnT8 Protects Pancreatic Islets from Hypoxia- and Cytokine-induced Cell Death The Journal of Endocrinology. Feb, 2022 | Pubmed ID: 35017316 Mechanisms of Weight Loss After Obesity Surgery Endocrine Reviews. Jan, 2022 | Pubmed ID: 34363458 Author Correction: Intravital Imaging of Islet Ca Dynamics Reveals Enhanced β Cell Connectivity After Bariatric Surgery in Mice Nature Communications. Sep, 2021 | Pubmed ID: 34545099 Macrophage Monocarboxylate Transporter 1 Promotes Peripheral Nerve Regeneration After Injury in Mice The Journal of Clinical Investigation. Nov, 2021 | Pubmed ID: 34491913 Intravital Imaging of Islet Ca Dynamics Reveals Enhanced β Cell Connectivity After Bariatric Surgery in Mice Nature Communications. Aug, 2021 | Pubmed ID: 34453049 Distinct Molecular Signatures of Clinical Clusters in People With Type 2 Diabetes: An IMI-RHAPSODY Study Diabetes. Nov, 2021 | Pubmed ID: 34376475 Author Correction: PDX1 MAFA β-cells Contribute to Islet Function and Insulin Release Nature Communications. Jul, 2021 | Pubmed ID: 34285239 Paired Box 6 Programs Essential Exocytotic Genes in the Regulation of Glucose-stimulated Insulin Secretion and Glucose Homeostasis Science Translational Medicine. Jun, 2021 | Pubmed ID: 34193609 Evaluation of Efficacy- Versus Affinity-driven Agonism with Biased GLP-1R Ligands P5 and Exendin-F1 Biochemical Pharmacology. Aug, 2021 | Pubmed ID: 34129856 Replication and Cross-validation of Type 2 Diabetes Subtypes Based on Clinical Variables: an IMI-RHAPSODY Study Diabetologia. Sep, 2021 | Pubmed ID: 34110439 Dysregulation of the Pdx1/Ovol2/Zeb2 Axis in Dedifferentiated β-cells Triggers the Induction of Genes Associated with Epithelial-mesenchymal Transition in Diabetes Molecular Metabolism. Nov, 2021 | Pubmed ID: 33989778 The Ca -binding Protein Sorcin Stimulates Transcriptional Activity of the Unfolded Protein Response Mediator ATF6 FEBS Letters. Jul, 2021 | Pubmed ID: 33960419 Consequences for Pancreatic β-Cell Identity and Function of Unregulated Transcript Processing Frontiers in Endocrinology. 2021 | Pubmed ID: 33763030 Chromatin 3D Interaction Analysis of the STARD10 Locus Unveils FCHSD2 As a Regulator of Insulin Secretion Cell Reports. Feb, 2021 | Pubmed ID: 33535042 PDX1 MAFA β-cells Contribute to Islet Function and Insulin Release Nature Communications. Jan, 2021 | Pubmed ID: 33514698 Importance of Both Imprinted Genes and Functional Heterogeneity in Pancreatic Beta Cells: Is There a Link? International Journal of Molecular Sciences. Jan, 2021 | Pubmed ID: 33498234 Sexually Dimorphic Roles for the Type 2 Diabetes-associated C2cd4b Gene in Murine Glucose Homeostasis Diabetologia. Apr, 2021 | Pubmed ID: 33492421 Genetic and Biased Agonist-mediated Reductions in β-arrestin Recruitment Prolong CAMP Signaling at Glucagon Family Receptors The Journal of Biological Chemistry. 2021 | Pubmed ID: 33268378 Pancreatic Sirtuin 3 Deficiency Promotes Hepatic Steatosis by Enhancing 5-Hydroxytryptamine Synthesis in Mice With Diet-Induced Obesity Diabetes. Jan, 2021 | Pubmed ID: 33087457 Adipocyte-specific Deletion of Tcf7l2 Induces Dysregulated Lipid Metabolism and Impairs Glucose Tolerance in Mice Diabetologia. Jan, 2021 | Pubmed ID: 33068125 Long Non-Coding RNAs As Key Modulators of Pancreatic β-Cell Mass and Function Frontiers in Endocrinology. 2020 | Pubmed ID: 33628198 Persistent or Transient Human β Cell Dysfunction Induced by Metabolic Stress: Specific Signatures and Shared Gene Expression with Type 2 Diabetes Cell Reports. Dec, 2020 | Pubmed ID: 33264613 Ligand-Specific Factors Influencing GLP-1 Receptor Post-Endocytic Trafficking and Degradation in Pancreatic Beta Cells International Journal of Molecular Sciences. Nov, 2020 | Pubmed ID: 33182425 Functional Genomics in Pancreatic β Cells: Recent Advances in Gene Deletion and Genome Editing Technologies for Diabetes Research Frontiers in Endocrinology. 2020 | Pubmed ID: 33162936 Covid-19 and Diabetes: A Complex Bidirectional Relationship Frontiers in Endocrinology. 2020 | Pubmed ID: 33133024 Control by Ca of Mitochondrial Structure and Function in Pancreatic β-cells Cell Calcium. Nov, 2020 | Pubmed ID: 32961506 Metabolic and Functional Specialisations of the Pancreatic Beta Cell: Gene Disallowance, Mitochondrial Metabolism and Intercellular Connectivity Diabetologia. Oct, 2020 | Pubmed ID: 32894309 Loss of β-cell Identity and Diabetic Phenotype in Mice Caused by Disruption of CNOT3-dependent MRNA Deadenylation Communications Biology. Aug, 2020 | Pubmed ID: 32859966 A Surrogate of Roux-en-Y Gastric Bypass (the Enterogastro Anastomosis Surgery) Regulates Multiple Beta-cell Pathways During Resolution of Diabetes in Ob/ob Mice EBioMedicine. Aug, 2020 | Pubmed ID: 32739864 The Roles of Cytosolic and Intramitochondrial Ca and the Mitochondrial Ca-uniporter (MCU) in the Stimulation of Mammalian Oxidative Phosphorylation The Journal of Biological Chemistry. Jul, 2020 | Pubmed ID: 32709760 Age Matters: Grading Granule Secretion in Beta Cells The Journal of Biological Chemistry. Jul, 2020 | Pubmed ID: 32620690 Signalling, Trafficking and Glucoregulatory Properties of Glucagon-like Peptide-1 Receptor Agonists Exendin-4 and Lixisenatide British Journal of Pharmacology. Sep, 2020 | Pubmed ID: 32436216 The Type 2 Diabetes Gene Product STARD10 is a Phosphoinositide-binding Protein That Controls Insulin Secretory Granule Biogenesis Molecular Metabolism. Oct, 2020 | Pubmed ID: 32416313 The Pore-forming Subunit MCU of the Mitochondrial Ca Uniporter is Required for Normal Glucose-stimulated Insulin Secretion in Vitro and in Vivo in Mice Diabetologia. Jul, 2020 | Pubmed ID: 32350566 The Influence of Peptide Context on Signaling and Trafficking of Glucagon-like Peptide-1 Receptor Biased Agonists ACS Pharmacology & Translational Science. Apr, 2020 | Pubmed ID: 32296773 Disconnect Between Signalling Potency and In vivo Efficacy of Pharmacokinetically Optimised Biased Glucagon-like Peptide-1 Receptor Agonists Molecular Metabolism. Jul, 2020 | Pubmed ID: 32278079 Glucose in the Hypothalamic Paraventricular Nucleus Regulates GLP-1 Release JCI Insight. Mar, 2020 | Pubmed ID: 32229720 Synthesis and in Vivo Behaviour of an Exendin-4-based MRI Probe Capable of β-cell-dependent Contrast Enhancement in the Pancreas Dalton Transactions (Cambridge, England : 2003). Apr, 2020 | Pubmed ID: 32207493 Glucocorticoid Metabolism in Obesity and Following Weight Loss Frontiers in Endocrinology. 2020 | Pubmed ID: 32153504 Dietary Substitution of SFA with MUFA Within High-fat Diets Attenuates Hyperinsulinaemia and Pancreatic Islet Dysfunction The British Journal of Nutrition. Aug, 2020 | Pubmed ID: 32122411 Effects on Pancreatic Beta and Other Islet Cells of the Glucose-dependent Insulinotropic Polypeptide Peptides. Mar, 2020 | Pubmed ID: 31751656 Metabolic and Functional Heterogeneity in Pancreatic β Cells Journal of Molecular Biology. Mar, 2020 | Pubmed ID: 31419404 Pancreatic Islet Secretion: Gabbling Via GABA Nature Metabolism. Nov, 2019 | Pubmed ID: 32694865 Agonist-induced Membrane Nanodomain Clustering Drives GLP-1 Receptor Responses in Pancreatic Beta Cells PLoS Biology. Aug, 2019 | Pubmed ID: 31430273 MTORC1 to AMPK Switching Underlies β-cell Metabolic Plasticity During Maturation and Diabetes The Journal of Clinical Investigation. Jul, 2019 | Pubmed ID: 31265435 An Essential Role for the Zn Transporter ZIP7 in B Cell Development Nature Immunology. Mar, 2019 | Pubmed ID: 30718914 Zn-transporters ZIP7 and ZnT7 Play Important Role in Progression of Cardiac Dysfunction Via Affecting Sarco(endo)plasmic Reticulum-mitochondria Coupling in Hyperglycemic Cardiomyocytes Mitochondrion. Jan, 2019 | Pubmed ID: 29307859 The α-cell in Diabetes Mellitus Nature Reviews. Endocrinology. Dec, 2018 | Pubmed ID: 30310153 The Impact of Pancreatic Beta Cell Heterogeneity on Type 1 Diabetes Pathogenesis Current Diabetes Reports. Sep, 2018 | Pubmed ID: 30251179 Chronic D-serine Supplementation Impairs Insulin Secretion Molecular Metabolism. Oct, 2018 | Pubmed ID: 30093356 Mice Harboring the Human R138X Loss-of-function Mutation Have Increased Insulin Secretory Capacity Proceedings of the National Academy of Sciences of the United States of America. Aug, 2018 | Pubmed ID: 30038024 Down-regulation of Vascular GLP-1 Receptor Expression in Human Subjects with Obesity Scientific Reports. Jul, 2018 | Pubmed ID: 30006590 The Effects of Kisspeptin on β-cell Function, Serum Metabolites and Appetite in Humans Diabetes, Obesity & Metabolism. Dec, 2018 | Pubmed ID: 29974637 Transcription Factor-7-like 2 () Gene Acts Downstream of the / Kinase to Control MTOR Signaling, β Cell Growth, and Insulin Secretion The Journal of Biological Chemistry. Sep, 2018 | Pubmed ID: 29967064 Neuronatin Regulates Pancreatic β Cell Insulin Content and Secretion The Journal of Clinical Investigation. Aug, 2018 | Pubmed ID: 29864031 Hypothalamic Arcuate Nucleus Glucokinase Regulates Insulin Secretion and Glucose Homeostasis Diabetes, Obesity & Metabolism. Sep, 2018 | Pubmed ID: 29748994 Targeting GLP-1 Receptor Trafficking to Improve Agonist Efficacy Nature Communications. Apr, 2018 | Pubmed ID: 29686402 Age-related Islet Inflammation Marks the Proliferative Decline of Pancreatic Beta-cells in Zebrafish ELife. Apr, 2018 | Pubmed ID: 29624168 Adrenaline Stimulates Glucagon Secretion by Tpc2-Dependent Ca Mobilization From Acidic Stores in Pancreatic α-Cells Diabetes. 06, 2018 | Pubmed ID: 29563152 Manipulation and Measurement of AMPK Activity in Pancreatic Islets Methods in Molecular Biology (Clifton, N.J.). 2018 | Pubmed ID: 29480490 Control of Insulin Secretion by GLP-1 Peptides. Feb, 2018 | Pubmed ID: 29412835 A Targeted RNAi Screen Identifies Endocytic Trafficking Factors That Control GLP-1 Receptor Signaling in Pancreatic β-Cells Diabetes. Mar, 2018 | Pubmed ID: 29284659 MiR-184 Expression is Regulated by AMPK in Pancreatic Islets FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. May, 2018 | Pubmed ID: 29269398 Glucocorticoids Reprogram β-Cell Signaling to Preserve Insulin Secretion Diabetes. Feb, 2018 | Pubmed ID: 29203512 Systems Biology of the IMIDIA Biobank from Organ Donors and Pancreatectomised Patients Defines a Novel Transcriptomic Signature of Islets from Individuals with Type 2 Diabetes Diabetologia. 03, 2018 | Pubmed ID: 29185012 Local and Regional Control of Calcium Dynamics in the Pancreatic Islet Diabetes, Obesity & Metabolism. Sep, 2017 | Pubmed ID: 28466490 Analysis of Purified Pancreatic Islet Beta and Alpha Cell Transcriptomes Reveals 11β-Hydroxysteroid Dehydrogenase (Hsd11b1) As a Novel Disallowed Gene Frontiers in Genetics. 2017 | Pubmed ID: 28443133 Molecular Phenotyping of Multiple Mouse Strains Under Metabolic Challenge Uncovers a Role for Elovl2 in Glucose-induced Insulin Secretion Molecular Metabolism. Apr, 2017 | Pubmed ID: 28377873 The Transcription Factor is Required for Pancreatic β Cell Identity, Glucose-regulated ATP Synthesis, and Ca Dynamics in Adult Mice The Journal of Biological Chemistry. May, 2017 | Pubmed ID: 28377501 Pancreatic Alpha Cell-selective Deletion of Tcf7l2 Impairs Glucagon Secretion and Counter-regulatory Responses to Hypoglycaemia in Mice Diabetologia. Jun, 2017 | Pubmed ID: 28343277 SLC30A9 Mutation Affecting Intracellular Zinc Homeostasis Causes a Novel Cerebro-renal Syndrome Brain : a Journal of Neurology. Apr, 2017 | Pubmed ID: 28334855 Remote Control of Glucose Homeostasis in Vivo Using Photopharmacology Scientific Reports. Mar, 2017 | Pubmed ID: 28331198 Hyperglycemia-Induced Changes in ZIP7 and ZnT7 Expression Cause Zn Release From the Sarco(endo)plasmic Reticulum and Mediate ER Stress in the Heart Diabetes. May, 2017 | Pubmed ID: 28232492 GABA Signaling: A Route to New Pancreatic β Cells Cell Research. Mar, 2017 | Pubmed ID: 28186081 Decreased STARD10 Expression Is Associated with Defective Insulin Secretion in Humans and Mice American Journal of Human Genetics. Feb, 2017 | Pubmed ID: 28132686 Diabetes: Controlling the Identity of the Adult Pancreatic β Cell Nature Reviews. Endocrinology. Mar, 2017 | Pubmed ID: 28106150 The Role of Oxidative Stress and Hypoxia in Pancreatic Beta-Cell Dysfunction in Diabetes Mellitus Antioxidants & Redox Signaling. Apr, 2017 | Pubmed ID: 27225690 MiRNAs in β-Cell Development, Identity, and Disease Frontiers in Genetics. 2016 | Pubmed ID: 28123396 Lipid-tuned Zinc Transport Activity of Human ZnT8 Protein Correlates with Risk for Type-2 Diabetes The Journal of Biological Chemistry. Dec, 2016 | Pubmed ID: 27875315 Modeling Type 2 Diabetes GWAS Candidate Gene Function in HESCs Cell Stem Cell. Sep, 2016 | Pubmed ID: 27588741 Photoswitchable Diacylglycerols Enable Optical Control of Protein Kinase C Nature Chemical Biology. Sep, 2016 | Pubmed ID: 27454932 Beta Cell Hubs Dictate Pancreatic Islet Responses To Glucose Cell Metabolism. Sep, 2016 | Pubmed ID: 27452146 Over-expression of Slc30a8/ZnT8 Selectively in the Mouse α Cell Impairs Glucagon Release and Responses to Hypoglycemia Nutrition & Metabolism. 2016 | Pubmed ID: 27390586 Cell Type-specific Deletion in Mice Reveals Roles for PAS Kinase in Insulin and Glucagon Production Diabetologia. Sep, 2016 | Pubmed ID: 27338626 Changes in the Expression of the Type 2 Diabetes-associated Gene VPS13C in the β-cell Are Associated with Glucose Intolerance in Humans and Mice American Journal of Physiology. Endocrinology and Metabolism. Aug, 2016 | Pubmed ID: 27329800 Zinc and Diabetes Archives of Biochemistry and Biophysics. Dec, 2016 | Pubmed ID: 27262257 Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function Cell Metabolism. May, 2016 | Pubmed ID: 27133129 Allosteric Optical Control of a Class B G-Protein-Coupled Receptor Angewandte Chemie (International Ed. in English). May, 2016 | Pubmed ID: 27059784 Proglucagon Promoter Cre-Mediated AMPK Deletion in Mice Increases Circulating GLP-1 Levels and Oral Glucose Tolerance PloS One. 2016 | Pubmed ID: 27010458 Calcium-insensitive Splice Variants of Mammalian E1 Subunit of 2-oxoglutarate Dehydrogenase Complex with Tissue-specific Patterns of Expression The Biochemical Journal. May, 2016 | Pubmed ID: 26936970 Disallowance of Acot7 in β-Cells Is Required for Normal Glucose Tolerance and Insulin Secretion Diabetes. May, 2016 | Pubmed ID: 26861785 Sorcin Links Pancreatic β-Cell Lipotoxicity to ER Ca2+ Stores Diabetes. Apr, 2016 | Pubmed ID: 26822088 The Two Pore Channel TPC2 is Dispensable in Pancreatic β-cells for Normal Ca²⁺ Dynamics and Insulin Secretion Cell Calcium. Jan, 2016 | Pubmed ID: 26769314 Proglucagon-Derived Peptides Do Not Significantly Affect Acute Exocrine Pancreas in Rats Pancreas. Aug, 2016 | Pubmed ID: 26731187 Molecular Genetic Regulation of Slc30a8/ZnT8 Reveals a Positive Association With Glucose Tolerance Molecular Endocrinology (Baltimore, Md.). Jan, 2016 | Pubmed ID: 26584158 Role of MicroRNAs in the Age-associated Decline of Pancreatic Beta Cell Function in Rat Islets Diabetologia. Jan, 2016 | Pubmed ID: 26474776 Intracellular Zinc in Insulin Secretion and Action: a Determinant of Diabetes Risk? The Proceedings of the Nutrition Society. Feb, 2016 | Pubmed ID: 26365743 Optical Control of Insulin Secretion Using an Incretin Switch Angewandte Chemie (International Ed. in English). Dec, 2015 | Pubmed ID: 26585495 Limited Impact on Glucose Homeostasis of Leptin Receptor Deletion from Insulin- or Proglucagon-expressing Cells Molecular Metabolism. Sep, 2015 | Pubmed ID: 26413468 Changes in MicroRNA Expression During Differentiation of Embryonic and Induced Pluripotent Stem Cells to Definitive Endoderm Gene Expression Patterns : GEP. 2015 | Pubmed ID: 26277621 The Zinc Transporter ZIP12 Regulates the Pulmonary Vascular Response to Chronic Hypoxia Nature. Aug, 2015 | Pubmed ID: 26258299 The Zinc Transporter Slc30a8/ZnT8 Is Required in a Subpopulation of Pancreatic α-Cells for Hypoglycemia-induced Glucagon Secretion The Journal of Biological Chemistry. Aug, 2015 | Pubmed ID: 26178371 Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Endolysosomal Two-pore Channels Modulate Membrane Excitability and Stimulus-Secretion Coupling in Mouse Pancreatic β Cells The Journal of Biological Chemistry. Aug, 2015 | Pubmed ID: 26152717 EZinCh-2: A Versatile, Genetically Encoded FRET Sensor for Cytosolic and Intraorganelle Zn(2+) Imaging ACS Chemical Biology. Sep, 2015 | Pubmed ID: 26151333 Loss of Liver Kinase B1 (LKB1) in Beta Cells Enhances Glucose-stimulated Insulin Secretion Despite Profound Mitochondrial Defects The Journal of Biological Chemistry. Aug, 2015 | Pubmed ID: 26139601 DICER Inactivation Identifies Pancreatic β-Cell "Disallowed" Genes Targeted by MicroRNAs Molecular Endocrinology (Baltimore, Md.). Jul, 2015 | Pubmed ID: 26038943 LKB1 and AMPKα1 Are Required in Pancreatic Alpha Cells for the Normal Regulation of Glucagon Secretion and Responses to Hypoglycemia Molecular Metabolism. Apr, 2015 | Pubmed ID: 25830091 Cell Biology. Pancreas Micromanages Autophagy Science (New York, N.Y.). Feb, 2015 | Pubmed ID: 25700502 Author Spotlight: Advancements and Challenges in β-Cells Differentiation from Pluripotent Stem Cells Ines Cherkaoui1, Qian Du2, Dieter Egli2, Shivani Misra1,3, Guy A. Rutter1,4,5 1Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Cell Biology and Functional Genomics, 2Departments of Pediatrics, Naomi Berrie Diabetes Center, Obstetrics and Gynecology, Columbia Stem Cell Initiative, Columbia University Irving Medical Center, Columbia University, 3Department of Diabetes, Imperial College Healthcare NHS Trust, 4Faculté de Médicine, Université de Montréal, 5Lee Kong Chian Imperial Medical School, Nanyang Technological University JoVE 65530 생물학
Author Spotlight: Advancements and Challenges in β-Cells Differentiation from Pluripotent Stem Cells Ines Cherkaoui1, Qian Du2, Dieter Egli2, Shivani Misra1,3, Guy A. Rutter1,4,5 1Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Cell Biology and Functional Genomics, 2Departments of Pediatrics, Naomi Berrie Diabetes Center, Obstetrics and Gynecology, Columbia Stem Cell Initiative, Columbia University Irving Medical Center, Columbia University, 3Department of Diabetes, Imperial College Healthcare NHS Trust, 4Faculté de Médicine, Université de Montréal, 5Lee Kong Chian Imperial Medical School, Nanyang Technological University JoVE 65530 생물학
