Tsuyoshi Miyakawa Division of Systems Medical Science, Institute for Comprehensive Medical Science Fujita Health University Biography Publications Institution JoVE Articles Tsuyoshi Miyakawa has not added a biography. If you are Tsuyoshi Miyakawa and would like to personalize this page please email our Author Liaison for assistance. Publications Reply to Warren Et Al. and Shay Et Al.: Commonalities Across Species Do Exist and Are Potentially Important Proceedings of the National Academy of Sciences of the United States of America. Jan, 2015 | Pubmed ID: 25540421 Genomic Responses in Mouse Models Greatly Mimic Human Inflammatory Diseases Proceedings of the National Academy of Sciences of the United States of America. Jan, 2015 | Pubmed ID: 25092317 IL1RAPL1 Knockout Mice Show Spine Density Decrease, Learning Deficiency, Hyperactivity and Reduced Anxiety-like Behaviours Scientific Reports. 2014 | Pubmed ID: 25312502 Transient Receptor Potential Ankyrin 1 in Spinal Cord Dorsal Horn is Involved in Neuropathic Pain in Nerve Root Constriction Rats Molecular Pain. 2014 | Pubmed ID: 25192906 SIRT1 Overexpression Ameliorates a Mouse Model of SOD1-linked Amyotrophic Lateral Sclerosis Via HSF1/HSP70i Chaperone System Molecular Brain. 2014 | Pubmed ID: 25167838 [Immaturity of Brain As an Endophenotype of Neuropsychiatric Disorders] Nihon Shinkei Seishin Yakurigaku Zasshi = Japanese Journal of Psychopharmacology. Jun, 2014 | Pubmed ID: 25076776 Mechanisms for Interferon-α-induced Depression and Neural Stem Cell Dysfunction Stem Cell Reports. Jul, 2014 | Pubmed ID: 25068123 Enhanced Stability of Hippocampal Place Representation Caused by Reduced Magnesium Block of NMDA Receptors in the Dentate Gyrus Molecular Brain. 2014 | Pubmed ID: 24893573 Transcriptomic Evidence for Immaturity of the Prefrontal Cortex in Patients with Schizophrenia Molecular Brain. 2014 | Pubmed ID: 24886351 Hippocampal Neurogenesis Regulates Forgetting During Adulthood and Infancy Science (New York, N.Y.). May, 2014 | Pubmed ID: 24812394 Comprehensive Behavioral Study of MGluR3 Knockout Mice: Implication in Schizophrenia Related Endophenotypes Molecular Brain. 2014 | Pubmed ID: 24758191 Targeted Deletion of the C-terminus of the Mouse Adenomatous Polyposis Coli Tumor Suppressor Results in Neurologic Phenotypes Related to Schizophrenia Molecular Brain. 2014 | Pubmed ID: 24678719 Comprehensive Behavioral Analysis of Cluster of Differentiation 47 Knockout Mice PloS One. 2014 | Pubmed ID: 24586890 Increased Behavioral and Neuronal Responses to a Hallucinogenic Drug in PACAP Heterozygous Mutant Mice PloS One. 2014 | Pubmed ID: 24586556 Absence of BRINP1 in Mice Causes Increase of Hippocampal Neurogenesis and Behavioral Alterations Relevant to Human Psychiatric Disorders Molecular Brain. 2014 | Pubmed ID: 24528488 Microendoscopy-assisted Muscle-preserving Interlaminar Decompression for Lumbar Spinal Stenosis: Clinical Results of Consecutive 105 Cases with More Than 3-year Follow-up Spine. Mar, 2014 | Pubmed ID: 24365896 Mice Lacking Collapsin Response Mediator Protein 1 Manifest Hyperactivity, Impaired Learning and Memory, and Impaired Prepulse Inhibition Frontiers in Behavioral Neuroscience. 2013 | Pubmed ID: 24409129 PRICKLE1 Interaction with SYNAPSIN I Reveals a Role in Autism Spectrum Disorders PloS One. 2013 | Pubmed ID: 24312498 In Vivo Evaluation of Cellular Activity in αCaMKII Heterozygous Knockout Mice Using Manganese-enhanced Magnetic Resonance Imaging (MEMRI) Frontiers in Integrative Neuroscience. 2013 | Pubmed ID: 24273499 Chronic Fluoxetine Treatment Reduces Parvalbumin Expression and Perineuronal Nets in Gamma-aminobutyric Acidergic Interneurons of the Frontal Cortex in Adult Mice Molecular Brain. 2013 | Pubmed ID: 24228616 Point Mutation in Syntaxin-1A Causes Abnormal Vesicle Recycling, Behaviors, and Short Term Plasticity The Journal of Biological Chemistry. Nov, 2013 | Pubmed ID: 24136198 Orexin Receptor-1 in the Locus Coeruleus Plays an Important Role in Cue-dependent Fear Memory Consolidation The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Sep, 2013 | Pubmed ID: 24005305 Chronic Overload of SEPT4, a Parkin Substrate That Aggregates in Parkinson's Disease, Causes Behavioral Alterations but Not Neurodegeneration in Mice Molecular Brain. 2013 | Pubmed ID: 23938054 Immature Dentate Gyrus: an Endophenotype of Neuropsychiatric Disorders Neural Plasticity. 2013 | Pubmed ID: 23840971 ENU-mutagenesis Mice with a Non-synonymous Mutation in Grin1 Exhibit Abnormal Anxiety-like Behaviors, Impaired Fear Memory, and Decreased Acoustic Startle Response BMC Research Notes. 2013 | Pubmed ID: 23688147 The Immature Dentate Gyrus Represents a Shared Phenotype of Mouse Models of Epilepsy and Psychiatric Disease Bipolar Disorders. Jun, 2013 | Pubmed ID: 23560889 Synaptosomal-associated Protein 25 Mutation Induces Immaturity of the Dentate Granule Cells of Adult Mice Molecular Brain. 2013 | Pubmed ID: 23497716 Post-natal Treatment by a Blood-brain-barrier Permeable Calpain Inhibitor, SNJ1945 Rescued Defective Function in Lissencephaly Scientific Reports. 2013 | Pubmed ID: 23390575 Deficiency of Schnurri-2, an MHC Enhancer Binding Protein, Induces Mild Chronic Inflammation in the Brain and Confers Molecular, Neuronal, and Behavioral Phenotypes Related to Schizophrenia Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Jul, 2013 | Pubmed ID: 23389689 Fluoxetine-induced Cortical Adult Neurogenesis Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. May, 2013 | Pubmed ID: 23303069 Increased Astrocytic ATP Release Results in Enhanced Excitability of the Hippocampus Glia. Feb, 2013 | Pubmed ID: 23018918 Behavioral Abnormalities Observed in Zfhx2-deficient Mice PloS One. 2012 | Pubmed ID: 23300874 Impaired Synaptic Clustering of Postsynaptic Density Proteins and Altered Signal Transmission in Hippocampal Neurons, and Disrupted Learning Behavior in PDZ1 and PDZ2 Ligand Binding-deficient PSD-95 Knockin Mice Molecular Brain. 2012 | Pubmed ID: 23268962 Comprehensive Behavioral Analysis of Pituitary Adenylate Cyclase-activating Polypeptide (PACAP) Knockout Mice Frontiers in Behavioral Neuroscience. 2012 | Pubmed ID: 23060763 α-Synuclein BAC Transgenic Mice As a Model for Parkinson's Disease Manifested Decreased Anxiety-like Behavior and Hyperlocomotion Neuroscience Research. Jun, 2012 | Pubmed ID: 22475625 M4 Muscarinic Receptor Knockout Mice Display Abnormal Social Behavior and Decreased Prepulse Inhibition Molecular Brain. 2012 | Pubmed ID: 22463818 全面的 ENU 诱导 Disc1 Q31L 和 L100P 基因突变小鼠的行为分析。 BMC Research Notes. Feb, 2012 | Pubmed ID: 22348257 裂小鼠空间记忆的右半球占主导地位。 Hippocampus. Feb, 2012 | Pubmed ID: 21069782 性腺瘤性息肉病大肠杆菌显性基因敲除小鼠显示 Hypoactivity 和年龄相关工作记忆。 Frontiers in Behavioral Neuroscience. 2011 | Pubmed ID: 22347851 DIP/希望虚增强了突触功能和巴恩斯迷宫中的性能。 Molecular Brain. 2011 | Pubmed ID: 22018352 AMPA 受体亚基 GluR1 和 GluR2 的表达所关联的齿状回颗粒细胞成熟。 Frontiers in Neuroscience. 2011 | Pubmed ID: 21927594 松弛素-3-缺陷小鼠焦虑相关的行为表明，略有改动。 Frontiers in Behavioral Neuroscience. 2011 | Pubmed ID: 21887138 P301S 突变体的人 Tau 转基因小鼠表现人类 Tauopathies 改变感觉运动门控与痴呆的早期症状。 PloS One. 2011 | Pubmed ID: 21698260 前脑特定一活动 CaMKKα 转基因小鼠海马依赖长期记忆中显示赤字。 Neurobiology of Learning and Memory. Sep, 2011 | Pubmed ID: 21558011 突触在上下文恐惧空调的 E3 连接酶刮板： 刮板合子和超量表达基因突变小鼠的广泛行为震撼。 PloS One. 2011 | Pubmed ID: 21390313 慢性氟西汀治疗 6 周以上降低成年小鼠的脑室下区神经发生。 Molecular Brain. 2011 | Pubmed ID: 21385396 对认知功能和淀粉样 β 代谢的 APP 超量表达小鼠慢性脑灌注不足的影响。 PloS One. 2011 | Pubmed ID: 21305033 灭活的成纤维细胞生长因子结合蛋白 3 会导致焦虑相关行为。 Molecular and Cellular Neurosciences. Jan, 2011 | Pubmed ID: 20851768 15Q 重叠综合征 ； 小鼠模型的探索性活动减少5-羟色胺信号干扰影响。 PloS One. 2010 | Pubmed ID: 21179543 色氨酸 2，3 双加氧酶在成熟颗粒细胞的成年小鼠海马齿状回中的表达式。 Molecular Brain. 2010 | Pubmed ID: 20815922 应激诱发的酪氨酸磷酸化的信号调节蛋白 α 调节行为静止在强迫的游泳测试中。 The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Aug, 2010 | Pubmed ID: 20685990 行为的三个 C57BL/6 Substrains 配置的文件。 Frontiers in Behavioral Neuroscience. 2010 | Pubmed ID: 20676234 [作为精神病候选人 Endophenotype 未成熟的海马齿状回]。 Nihon Shinkei Seishin Yakurigaku Zasshi = Japanese Journal of Psychopharmacology. Jun, 2010 | Pubmed ID: 20666142 案例报告： 痛苦四肢/移动四肢： 两种情况的报告。 Clinical Orthopaedics and Related Research. Dec, 2010 | Pubmed ID: 20585912 表征功能的海马萎缩血管性痴呆小鼠模型。 Stroke; a Journal of Cerebral Circulation. Jun, 2010 | Pubmed ID: 20448204 Serotonergic 抗抑郁药的海马神经元成熟的逆转。 Proceedings of the National Academy of Sciences of the United States of America. May, 2010 | Pubmed ID: 20404165 全面的钙钙调素依赖性蛋白激酶四、 基因敲除小鼠的行为分析。 PloS One. 2010 | Pubmed ID: 20209163 SDOP-DB： 鼠标表型分析比较标准化协议数据库。 Bioinformatics (Oxford, England). Apr, 2010 | Pubmed ID: 20194625 神经诱导缺血发生的皮层层 1 祖细胞。 Nature Neuroscience. Feb, 2010 | Pubmed ID: 20037576 Nardilysin 规定了弥漫的成熟和髓鞘化中央和周围神经系统。 Nature Neuroscience. Dec, 2009 | Pubmed ID: 19935654 异常的脑结构和葛兰素史克 3alpha 基因突变小鼠中的行为。 Molecular Brain. 2009 | Pubmed ID: 19925672 KF-1 泛素连接酶： 抑制焦虑。 Frontiers in Neuroscience. May, 2009 | Pubmed ID: 19753093 基础工作内存赤字在 Alpha CaMKII 显性基因敲除小鼠的神经活性变化。 Frontiers in Behavioral Neuroscience. 2009 | Pubmed ID: 19750198 钙蛋白酶抑制 LIS1 表达增加和部分营救 Lissencephaly 小鼠模型体内表型。 Nature Medicine. Oct, 2009 | Pubmed ID: 19734909 宫内的环境基因组互动与儿童的发展 （4）： 脑行为 Phenotypying 的基因工程小鼠行为的全面测试电池使用神经精神性疾病的研究。 The Journal of Toxicological Sciences. 2009 | Pubmed ID: 19571483 伴随着异常的神经胶质细胞的相互作用和减少传导速度改变的髓鞘髓鞘蛋白基因表达显示认知功能障碍小鼠。 The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jul, 2009 | Pubmed ID: 19571127 自闭症中看到的人类 15q11 13 重复染色体工程小鼠模型中的异常行为。 Cell. Jun, 2009 | Pubmed ID: 19563756 社会行为异常、 多动，并削弱远程空间内存，增加 D1 介导的多巴胺能神经元一氧化氮合酶基因敲除小鼠的信号。 Molecular Brain. 2009 | Pubmed ID: 19538708 兰尼碱受体的综合行为震撼键入 3 (RyR3) 基因敲除小鼠： 在两个社会互动测试社会接触持续时间减少。 Frontiers in Behavioral Neuroscience. 2009 | Pubmed ID: 19503748 [基因、 行为和精神障碍]。 Tanpakushitsu Kakusan Koso. Protein, Nucleic Acid, Enzyme. Mar, 2008 | Pubmed ID: 21089339 正常线粒体呼吸功能的远程小鼠空间记忆的至关重要。 Molecular Brain. 2008 | Pubmed ID: 19087269 Protocadherin-α 异构体小鼠更改上下文下调担心空调和空间工作记忆。 The European Journal of Neuroscience. Oct, 2008 | Pubmed ID: 18973563 缺乏 Kf-1 基因的小鼠表现出更多的焦虑-但不是绝望类似行为。 Frontiers in Behavioral Neuroscience. 2008 | Pubmed ID: 18958194 受损的长期记忆力和工作记忆的三大雅基因突变小鼠与 Dtnbp1，精神分裂症易感基因定位在删除操作。 Molecular Brain. 2008 | Pubmed ID: 18945333 钙蛋白酶抑制蛋白基因敲除小鼠的综合行为 Phenotyping。 Molecular Brain. 2008 | Pubmed ID: 18803809 Alpha CaMKII 虚导致未成熟的海马齿状回，精神病新型候选人 Endophenotype。 Molecular Brain. 2008 | Pubmed ID: 18803808 成人前脑的结构和功能完整性连续神经发生的作用。 Nature Neuroscience. Oct, 2008 | Pubmed ID: 18758458 YWHAE，作为精神分裂症可能易感基因编码 14-3-3epsilon 基因的标识。 Human Molecular Genetics. Oct, 2008 | Pubmed ID: 18658164 缺乏 FEZ1 精神分裂症相关蛋白的小鼠表现多动和中枢兴奋剂对提高响应能力。 Human Molecular Genetics. Oct, 2008 | Pubmed ID: 18647754 [调查中精神疾病的基因到行为途径： 方法使用综合行为测试电池上的基因工程小鼠]。 Nihon Shinkei Seishin Yakurigaku Zasshi = Japanese Journal of Psychopharmacology. Jun, 2008 | Pubmed ID: 18646600 增加 Neuropsin (激肽释放酶相关肽 8） 基因缺陷小鼠类似焦虑的行为。 Behavioral Neuroscience. Jun, 2008 | Pubmed ID: 18513120 树突棘较小、 较弱的突触传递，但缺乏 Shank1 小鼠增强空间学习。 The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2008 | Pubmed ID: 18272690 增加小鼠缺的纹状体中等多刺神经元特异性磷酸二酯酶 10A2 的社会互动。 Journal of Neurochemistry. Apr, 2008 | Pubmed ID: 18088367 NMDA 受体亚单位 NR3B 小鼠遗传消融揭示了神经元和 Nonmotoneuronal 的表型。 The European Journal of Neuroscience. Sep, 2007 | Pubmed ID: 17880385 改变对吗啡和可卡因在脚手架蛋白大马璘基因敲除小鼠的敏感性。 Proceedings of the National Academy of Sciences of the United States of America. Sep, 2007 | Pubmed ID: 17766434 选择性记忆障碍的工作的慢性脑低灌注小鼠模型。 Stroke; a Journal of Cerebral Circulation. Oct, 2007 | Pubmed ID: 17761909 脑-行为 Phenotypying 的基因工程小鼠的神经精神性疾病研究的影响。 Neuroscience Research. Jun, 2007 | Pubmed ID: 17524507 浓缩的环境影响在成年小鼠和细胞存活的新生儿其海马与抑郁症相关的行为。 Behavioural Brain Research. Jun, 2007 | Pubmed ID: 17397941 综合大脑研究的鼠标联络。 Neuroscience Research. Jun, 2007 | Pubmed ID: 17382419 需要制止 α-synuclein 神经毒性 Sept4，突触前脚手架和路易体的一个组成部分。 Neuron. Feb, 2007 | Pubmed ID: 17296554 调查中精神失常基因到行为途径： 对转基因小鼠的行为的全面测试电池的使用。 Annals of the New York Academy of Sciences. Nov, 2006 | Pubmed ID: 17185513 精神分裂症有关行为测试在啮齿动物模型： 人类独有的一种紊乱吗？ Biological Psychiatry. Jun, 2006 | Pubmed ID: 16797265 NFAT 增加剂量的 21 号染色体上的 DSCR1 和 DYRK1A 时的异常。 Nature. Jun, 2006 | Pubmed ID: 16554754 [精神科疾病的应力和动物模型]。 Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica. Sep, 2005 | Pubmed ID: 16272762 周围神经髓鞘轴突雪旺氏细胞紧密连接： 克劳丁-19-缺陷小鼠的教训。 The Journal of Cell Biology. May, 2005 | Pubmed ID: 15883201 加强了可卡因的响应能力和代谢型谷氨酸受体亚型 2 基因敲除小鼠受损电机协调。 Proceedings of the National Academy of Sciences of the United States of America. Mar, 2005 | Pubmed ID: 15753323 M2 毒蕈碱样乙酰胆碱受体敲除小鼠显示行为的灵活性、 工作记忆和海马可塑性的赤字。 The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Nov, 2004 | Pubmed ID: 15537882 通过听觉传导通路的直观标记条件恐惧的加速度。 Nature Neuroscience. Sep, 2004 | Pubmed ID: 15322551 编码钙调神经磷酸 γ 亚基的 PPP3CC，8p21.3 基因的遗传变异与精神分裂症的关联证据。 Proceedings of the National Academy of Sciences of the United States of America. Jul, 2003 | Pubmed ID: 12851458 有条件的钙调神经磷酸基因敲除小鼠表现出与精神分裂症有关的多个异常行为。 Proceedings of the National Academy of Sciences of the United States of America. Jul, 2003 | Pubmed ID: 12851457 背景和线索恐惧制约试验小鼠中使用视频分析系统 Hirotaka Shoji1,2, Keizo Takao2,3, Satoko Hattori1,2, Tsuyoshi Miyakawa1,2,3 1Division of Systems Medical Science, Institute for Comprehensive Medical Science, Fujita Health University, 2Japan Science and Technology Agency, Core Research for Evolutionary Science and Technology (CREST), 3Center for Genetic Analysis of Behavior, National Institute for Physiological Sciences, National Institutes of Natural Sciences JoVE 50871 행동분석학 T-迷宫强迫交替和评估工作，并参考在小鼠记忆的左，右的歧视任务 Hirotaka Shoji1,2, Hideo Hagihara1, Keizo Takao3, Satoko Hattori1,2,3, Tsuyoshi Miyakawa1,2,3 1Division of Systems Medical Science, Institute for Comprehensive Medical Science, Fujita Health University, 2Japan Science and Technology Agency, Core Research for Evolutionary Science and Technology (CREST), 3Center for Genetic Analysis of Behavior, National Institute for Physiological Sciences, National Institutes of Natural Sciences JoVE 3300 신경과학 从成年小鼠海马齿状回的剖析 Hideo Hagihara1,2, Keiko Toyama1,2, Nobuyuki Yamasaki1,3, Tsuyoshi Miyakawa1,2,4,5 1Japan Science and Technology Agency, Core Research for Evolutionary Science and Technology (CREST), 2Division of Systems Medical Science, Institute for Comprehensive Medical Science, Fujita Health University, 3Department of Psychiatry, Graduate School of Medicine, Kyoto University, 4Genetic Engineering and Functional Genomics Group, Horizontal Medical Research Organization, Graduate School of Medicine, Kyoto University, 5Center for Genetic Analysis of Behavior, National Institute for Physiological Sciences, National Institutes of Natural Sciences JoVE 1543 생물학 对小鼠高架十字迷宫 Munekazu Komada1, Keizo Takao1,2, Tsuyoshi Miyakawa2 1Genetic Engineering and Functional Genomics Unit, Frontier Technology Center, Graduate School of Medicine, Kyoto University, 2Institute for Comprehensive Medical Science Division of Systems Medicine, Fujita Health University JoVE 1088 생물학 光/暗转换测试小鼠 Keizo Takao1, Tsuyoshi Miyakawa1 1Genetic Engineering and Functional Genomics Unit, Horizontal Medical Research Organization, Graduate School of Medicine, Kyoto University JoVE 104 생물학
背景和线索恐惧制约试验小鼠中使用视频分析系统 Hirotaka Shoji1,2, Keizo Takao2,3, Satoko Hattori1,2, Tsuyoshi Miyakawa1,2,3 1Division of Systems Medical Science, Institute for Comprehensive Medical Science, Fujita Health University, 2Japan Science and Technology Agency, Core Research for Evolutionary Science and Technology (CREST), 3Center for Genetic Analysis of Behavior, National Institute for Physiological Sciences, National Institutes of Natural Sciences JoVE 50871 행동분석학
T-迷宫强迫交替和评估工作，并参考在小鼠记忆的左，右的歧视任务 Hirotaka Shoji1,2, Hideo Hagihara1, Keizo Takao3, Satoko Hattori1,2,3, Tsuyoshi Miyakawa1,2,3 1Division of Systems Medical Science, Institute for Comprehensive Medical Science, Fujita Health University, 2Japan Science and Technology Agency, Core Research for Evolutionary Science and Technology (CREST), 3Center for Genetic Analysis of Behavior, National Institute for Physiological Sciences, National Institutes of Natural Sciences JoVE 3300 신경과학
从成年小鼠海马齿状回的剖析 Hideo Hagihara1,2, Keiko Toyama1,2, Nobuyuki Yamasaki1,3, Tsuyoshi Miyakawa1,2,4,5 1Japan Science and Technology Agency, Core Research for Evolutionary Science and Technology (CREST), 2Division of Systems Medical Science, Institute for Comprehensive Medical Science, Fujita Health University, 3Department of Psychiatry, Graduate School of Medicine, Kyoto University, 4Genetic Engineering and Functional Genomics Group, Horizontal Medical Research Organization, Graduate School of Medicine, Kyoto University, 5Center for Genetic Analysis of Behavior, National Institute for Physiological Sciences, National Institutes of Natural Sciences JoVE 1543 생물학
对小鼠高架十字迷宫 Munekazu Komada1, Keizo Takao1,2, Tsuyoshi Miyakawa2 1Genetic Engineering and Functional Genomics Unit, Frontier Technology Center, Graduate School of Medicine, Kyoto University, 2Institute for Comprehensive Medical Science Division of Systems Medicine, Fujita Health University JoVE 1088 생물학
光/暗转换测试小鼠 Keizo Takao1, Tsuyoshi Miyakawa1 1Genetic Engineering and Functional Genomics Unit, Horizontal Medical Research Organization, Graduate School of Medicine, Kyoto University JoVE 104 생물학
