Nasal Microbiota
Nasal Microbiota - Related Videos
01:15
Assessing the Role of Gut Microbiota in Modulating Hepatitis B Infection in Mice
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2026
Take a control mouse with a normal gut microbiota and an experimental mouse with depleted gut microbiota. The depletion compromises the integrity of the gut barrier.This enables bacteria to translocate through the blood vessel into the liver tissue.Inject both mice with the hepatitis B virus or HBV plasmid to induce an HBV infection in the liver tissue.In the control mouse, the T cell detects an infected liver cell through the interaction of its receptors with viral antigens, and produces...
07:54
A Method to Assess Bacteriocin Effects on the Gut Microbiota of Mice
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Cited by 9 •
2017
Bacteriocins are believed to play a key role in defining microbial diversity in different ecological niches. Here, we describe an efficient procedure to assess how bacteriocins affect gut microbiota composition in an animal model.
01:27
Oral Infection Alters the Gut Microbiota in a Rat Model
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2026
Begin with a rat model with sutures tied around its upper molar teeth to support bacterial colonization.Repeatedly smear the sutures with a gum disease-causing oral pathogenic bacterium using a gel-like solution.The bacteria colonize the gum around the sutures.Colonization triggers inflammation and damages the tissues.The bacteria release toxins that diffuse through damaged tissues and enter the bloodstream.These circulating toxins reach the gut, cause inflammation, disrupt the epithelial...
09:19
Isolating Nasal Olfactory Stem Cells from Rodents or Humans
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Cited by 98 •
2011
We describe here a method for biopsying olfactory mucosa from rat and human nasal cavities. These biopsies can be used for either identifying molecular anomalies in brain diseases or isolating multipotent adult stem cells that can be utilized for cell transplantation in animal models of brain trauma/disease.
05:59
Nasal Wipes for Influenza A Virus Detection and Isolation from Swine
0 Views •
Cited by 19 •
2015
The authors present a protocol to collect swine nasal wipes to detect and isolate influenza A viruses.
FAQs
Resident microbes may reduce pathogen colonization through several forms of ecological competition. By occupying attachment sites, using available nutrients, or producing inhibitory molecules, they can make the nasal environment less favorable for invading organisms. These mechanisms help explain why changes in community composition may alter susceptibility to respiratory infection and why microbial interactions are important in biology research.
Nasal mucus is not merely a surrounding material; it is one of the conditions shaping which organisms persist. Environmental conditions and host factors also influence community composition, while microbial competition can modify the resulting balance. Considering these variables helps researchers avoid treating nasal communities as fixed and supports more careful comparisons among respiratory health or disease states.
Interactions with the nasal mucosa can affect both local immune activity and barrier function. This creates a two-way relationship: host conditions help shape microbial communities, and resident organisms may influence how the mucosa responds to potential threats. Examining that relationship gives biology researchers a framework for connecting community changes with respiratory infection susceptibility without assuming that every detected microbe is harmful.
Culture and DNA-based profiling are approaches for studying nasal communities. Their use supports analysis of community composition and investigation of links with respiratory disease, antimicrobial responses, and strategies for maintaining or restoring healthy microbial communities. In biology, these methods turn the nasal ecosystem into an experimentally examinable subject rather than relying only on assumptions about individual microbes.
Interpretation should account for the conditions that shape the community, including mucus, environmental conditions, host factors, and microbial competition. A detected difference may therefore reflect more than the presence or absence of one organism. Considering these influences helps researchers evaluate community-level patterns and connect them more cautiously with infection susceptibility or other respiratory outcomes.
Research on Nasal Microbiota has applications across respiratory biology. Investigators can examine relationships between community composition and respiratory disease, investigate antimicrobial responses, and explore ways to maintain or restore healthy microbial communities. The broader goal is not simply to catalog microorganisms, but to understand how their interactions with the mucosa and with one another may affect respiratory health.