Nanoparticle Encapsulation
Nanoparticle Encapsulation - Related Videos
03:06
Encapsulating Nerve Growth Factor in High-Density Lipoprotein-Mimicking Nanoparticles
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2025
Source: Zhu, J., et. al., Preparation and Characterization of Novel HDL-mimicking Nanoparticles for Nerve Growth Factor Encapsulation. J. Vis. Exp. (2017)This video demonstrates the stepwise assembly of NGF-loaded HDL-mimicking nanoparticles using protamine-assisted encapsulation and lipid-based self-assembly for potential neurotrophic delivery applications.
08:24
Preparation and Characterization of Novel HDL-mimicking Nanoparticles for Nerve Growth Factor Encapsulation
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Cited by 4 •
2017
Simple homogenization was used to prepare novel, high-density, lipoprotein-mimicking nanoparticles to encapsulate nerve growth factor. Challenges, detailed protocols for nanoparticle preparation, in vitro characterization, and in vivo studies are described in this article.
11:06
Encapsulating Cytochrome c in Silica Aerogel Nanoarchitectures without Metal Nanoparticles while Retaining Gas-phase Bioactivity
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Cited by 1 •
2016
This procedure describes how to encapsulate cytochrome c (cyt. c) in silica (SiO2) sol-gels, process these gels to form bioaerogels, and use these bioaerogels to rapidly recognize nitric oxide (NO) through a gas-phase reaction. This type of protocol may aid in the future development of biosensors or other bioanalytical devices.
10:16
Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier
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Cited by 3 •
2017
A liquid crystal nanoparticle (LCNP) nanocarrier is exploited as a vehicle for the controlled delivery of a hydrophobic cargo to the plasma membrane of living cells.
10:12
Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles
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Cited by 72 •
2019
Flash NanoPrecipitation (FNP) is a scalable approach to produce polymeric core-shell nanoparticles. Lab-scale formulations for the encapsulation of hydrophobic or hydrophilic therapeutics are described.
FAQs
Physical entrapment retains molecules within the carrier, whereas adsorption associates them with the particle surface. Chemical interactions provide another means of holding the active substance through molecular associations. These distinct mechanisms influence how efficiently a compound is loaded and how it is released, making interaction type an important chemical design variable.
Particle size and surface properties influence both the amount of substance associated with a carrier and its subsequent release behavior. Because these features connect nanoscale structure with molecular function, changing them can alter how a formulation protects, stabilizes, or delivers its contents. They therefore provide key variables for controlling performance.
Polymers, lipids, inorganic materials, and hybrid structures offer different chemical environments for incorporating active substances. The selected material affects whether molecules are physically trapped, associated with a surface, or held through chemical interactions. Carrier choice consequently helps determine protection, stabilization, loading behavior, and release characteristics for a particular compound.
The carrier’s composition, structure, and surface characteristics determine how it interacts with an incorporated molecule. Those interactions govern practical behaviors such as stability, solubility, loading, and release. In chemistry, this structure-function relationship allows nanoscale materials to be designed not only as containers, but also as systems with tailored molecular performance.
Development centers on matching the active substance with an appropriate carrier material and incorporation mechanism. Researchers also consider particle size and surface properties because these variables affect loading and release. The resulting system can then be judged by whether it improves the compound’s protection, stability, solubility, or control over delivery.
Applications extend across drug formulation, catalysis, sensing, imaging, and materials design. Encapsulation can protect or stabilize therapeutic molecules and imaging agents, while nanoscale carriers can also support catalyst-related systems and sensing materials. These uses reflect the broader value of controlling how compounds behave through their association with engineered particles.