Graft Dilation
Graft Dilation - Related Videos
07:37
Mouse Models for Graft Arteriosclerosis
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Cited by 17 •
2013
We describe protocols for our mouse graft arteriosclerois (GA) models which involve interposition of a mouse vessel segment into a recipient of the same inbred strain. By backcrossing additional genetic changes into the vessel donor, the model can assess the effect of specific genes on GA.
01:30
Cardiomyopathy II: Dilated Cardiomyopathy
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2025
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
03:35
A Technique for Human Skin Grafting in a Mouse Model
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2025
This video demonstrates a method for grafting human skin onto an immunodeficient mouse with a suppressed neutrophil response. The method involves applying human split-thickness skin to the mouse's graft bed, sealing it, and covering it for recovery. Eventually, the human skin adheres to the mouse's skin, establishing vascularization and circulation, resulting in a successful skin xenograft.
05:47
Isolation and Transplantation of Different Aged Murine Thymic Grafts.
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Cited by 14 •
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This report provides a detailed description of transplanting murine thymi from different aged donor mice under the kidney capsule of immunodeficient mouse recipients. The goal of this approach is to model T cell development and thymic selection events in vivo.
13:04
Generation and Grafting of Tissue-engineered Vessels in a Mouse Model
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Cited by 13 •
2015
Here, we present a protocol to generate tissue engineered vessel grafts that are functional for grafting into mice by double seeding partially induced pluripotent stem cell (PiPSC) - derived smooth muscle cells and PiPSC - derived endothelial cells on a decellularized vessel scaffold bioreactor.
FAQs
Repeated pressure and pulse-related loading place mechanical demands on the graft wall. When those forces exceed the support provided by the graft structure, the material may deform and the diameter can increase over time. This mechanical relationship helps explain why dilation is monitored as a potential threat to the durability of a vascular repair.
Progressive enlargement may reflect changes in the graft material itself, remodeling at the suture line, or both processes. These changes can modify how forces are distributed through the repair and may allow continued expansion. For this reason, evaluating graft performance requires attention not only to diameter measurements but also to material behavior and host-graft interactions.
Clinicians interpret graft diameter measurements together with serial trends, symptoms, and associated findings rather than relying on a single observation. A stable pattern may represent remodeling that is not currently compromising the repair, whereas progressive enlargement or concerning clinical findings can indicate greater risk. This distinction supports individualized surveillance and treatment planning.
Follow-up centers on serial imaging, with repeated measurements of graft diameter over time. Clinicians compare these measurements with symptoms and associated findings to assess whether the repair remains stable or is enlarging in a clinically important way. The resulting risk assessment helps determine appropriate follow-up intervals and whether further evaluation or revision should be considered.
Revision becomes a consideration when surveillance suggests clinically significant enlargement or when symptoms and associated findings indicate that the repair may no longer be durable. The available approaches include endovascular revision and open revision. Choosing between them is part of clinical decision-making guided by the observed graft changes and the overall risk assessment.
Research in these areas seeks to explain why some repairs undergo more enlargement than others and how graft structure responds after implantation. Studying material properties alongside host-graft interactions may identify ways to improve long-term durability. These findings can also support better postoperative surveillance strategies and more informed approaches to managing abnormal graft changes in vascular medicine.