Drug Administration
Drug Administration - Related Videos
09:25
Assessment of Ultrasonic Vocalizations During Drug Self-administration in Rats
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Cited by 17 •
2010
Drug self-administration and ultrasonic vocalizations (USV) are used as behavioral assessments in animal research, but rarely in combination. The purpose of this article is to describe the advantages of recording USVs during drug self-administration procedures to assess affective responses to drug experience.
03:37
Intranasal Drug Administration in Mice via Pipette and Reverse-Cannulation for Nose-to-Brain Drug Delivery
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2025
Source: Kanazawa, T., et al. Novel Methods for Intranasal Administration Under Inhalation Anesthesia to Evaluate Nose-to-Brain Drug Delivery. J. Vis. Exp. (2018)This video demonstrates the intranasal administration of radiolabeled drugs in an anesthetized mouse to achieve nose-to-brain drug delivery. It explains how drugs cross the nasal epithelium and travel via neuronal pathways to reach the brain, as well as how ciliary motion influences drug retention and clearance. Additionally, the video...
06:08
Evaluation of Drug Sorption to PVC- and Non-PVC-based Tubes in Administration Sets Using a Pump
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Cited by 8 •
2017
We report a method for drug sorption evaluation using a pump and model drugs (diazepam and tacrolimus). After drug analysis using high-performance liquid chromatography, drug concentrations and sorption levels in the tubes of administration sets are calculated.
09:29
Self-administration Studies
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2023
Behavioral reinforcement induced by the rewarding feelings following substance use sometimes leads to addiction, which is demonstrated by increased self-administration. Drug self-administration studies in rodents model human behavior during drug abuse. These models are useful in understanding the neurobiological behavior of addiction in order to help scientists discover new treatments for drug dependence. This video reviews the concepts underlying self-administration studies. A general...
01:22
Routes of Drug Administration: Overview
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2023
Drug administration involves delivering drugs to the body through various routes, such as enteral, parenteral, and topical. Enteral administration refers to drugs absorbed through the gastrointestinal tract. They can be swallowed (perorally), placed under the tongue (sublingually), or on the inner lining of the cheeks (buccally). Perorally administered drugs take time to be absorbed and have a slower onset of action. The rectal route is another form of enteral administration, which allows for...
FAQs
The route alters absorption, distribution, and metabolism, which changes how much compound reaches neural targets and how quickly it may act. Oral, intravenous, intraperitoneal, and intracerebral delivery can therefore produce different biological outcomes even when investigators study the same compound. Selecting a route is especially important when blood-brain barrier passage may limit access to the nervous system.
The blood-brain barrier can restrict a compound’s movement from the circulation into neural tissue. Consequently, administration results depend not only on the drug itself but also on whether the selected route permits sufficient access to the intended brain targets. This consideration helps researchers interpret differences in neural, behavioral, or therapeutic effects across administration strategies.
Controlled administration allows investigators to compare biological effects across defined dosing conditions. By relating drug exposure to changes in neurotransmitter systems, neural circuits, or behavior, researchers can characterize how responses vary with dose. This approach helps distinguish weak, effective, and potentially excessive responses while supporting systematic evaluation of candidate treatments in neuroscience.
Researchers choose among these routes according to the desired pattern of absorption, distribution, metabolism, and neural access. Oral, intravenous, and intraperitoneal delivery differ in how compounds enter and move through the body, whereas intracerebral injection places the compound within the nervous system. The choice should therefore match the target process and the study’s biological question.
A study typically specifies the compound, selects an administration route, applies controlled dosing conditions, and then measures relevant outcomes. Depending on the question, investigators may assess neurotransmitter systems, neural circuits, behavior, or dose-response relationships. Keeping delivery conditions consistent helps researchers attribute observed differences to the treatment rather than to uncontrolled variation in administration.
This approach is useful when researchers need to connect a compound with changes in nervous-system function or evaluate a potential therapy. Applications include investigations of pain, epilepsy, neurodegeneration, and psychiatric disease. Comparing controlled administration outcomes can reveal effects on neural processes and behavior while supporting preclinical assessment of treatments before further development.