Corpus Callosum

The corpus callosum is the largest bundle of nerve fibers in the brain, linking the left and right cerebral hemispheres to coordinate their activity. Its axons transmit electrical signals between corresponding and complementary cortical regions, allowing sensory information, motor commands, language, attention, and other cognitive processes to be integrated across the hemispheres. In psychology and neuroscience, studying the corpus callosum helps explain hemispheric specialization, interhemispheric communication, and how the brain combines information into unified perception and behavior. Research on callosal development, injury, and disconnection also informs understanding of cognition, neurological disorders, and individual differences in brain organization.

Corpus Callosum - Related Videos

Research

JoVE Journal - Neuroscience

Exploring Deep Space - Uncovering the Anatomy of Periventricular Structures to Reveal the Lateral Ventricles of the Human Brain

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Cited by 2 •

2017

This paper demonstrates the effective use of a fiber dissection method to reveal the superficial white matter tracts and periventricular structures of the human brain, in three-dimensional space, to aid student comprehension of ventricular morphology.

Osmotic Pump-Based Neurotherapeutic Drug Delivery in a Demyelinated Mouse Model

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2025

Source: Wang, X. et. al., Osmotic Pump-based Drug-delivery for In Vivo Remyelination Research on the Central Nervous System. J. Vis. Exp. (2021)This video demonstrates the method for delivering neurotherapeutic drugs using an osmotic pump in a demyelinated mouse model. The controlled drug release promotes remyelination by activating myelin-producing cells in the corpus callosum.

Micro-dissection of Rat Brain for RNA or Protein Extraction from Specific Brain Region

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Cited by 171 •

2007

Micro-dissection of rat brain into various regions is extremely important for the study of different neurodegenerative diseases. This video demonstrates micro-dissection of four major brain regions include olfactory bulb, frontal cortex, striatum and hippocampus in fresh rat brain tissue. Useful tips for quick removal of respective regions to avoid RNA and protein degradation of the tissue are given.

Education

JoVE Science Education - Psychology
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The Split Brain

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2023

Source: Laboratories of Jonas T. Kaplan and Sarah I. Gimbel—University of Southern California The study of how damage to the brain affects cognitive functioning has historically been one of the most important tools for cognitive neuroscience. While the brain is one of the most well protected parts of the body, there are many events that can affect the functioning of the brain. Vascular issues, tumors, degenerative diseases, infections, blunt force traumas, and neurosurgery are just some of the...

Isolating Microglia from Mouse Brain Demyelinating Lesions Using Magnetic Activated Cell Sorting

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2025

This video demonstrates a protocol for extracting microglial cells from demyelinating lesions in mouse brains using magnetic cell sorting. The protocol involves dissecting the lesioned brain tissue containing microglial cells, treating the tissue with specific enzymes to obtain a single-cell suspension, and utilizing microglial receptor-specific magnetic beads to isolate the microglial cells.

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