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Epigenetics Research Methods: Assessing Epigenetic States and Genomic Positional Information in Populations and Single Cells

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Guest Editors

Dr. Eliza Small

Thermo Fisher Scientific

Dr. Eliza Small is a product manager at Thermo Fisher Scientific. In this role, Eliza manages the epigenetic antibody portfolio along with supporting development and validation antibody roadmaps and leads an antibody collaboration program. Prior to joining Thermo Fisher Scientific, Eliza was a Ruth Kirschstein postdoctoral fellow at Northwestern University where she studied the impact of nucleosome positioning in various perturbations, including histone mutations. Eliza received her BA at Vassar College and her PhD from The University of Chicago, where she studied mechanisms for regulating RNA splicing. Eliza serves as a mentor for Women In Bio Chicago and is passionate about diversity and inclusion in science.

Dr. Parisha Shah

University of Pennsylvania Perelman School of Medicine

Dr. Parisha Shah is a Senior Research Investigator at the University of Pennsylvania, Perelman School of Medicine in the Department of Medicine and the Epigenetics Institute. Parisha studies genome organization during development to understand the molecular mechanisms underlying the establishment of cellular identity, maintenance of cellular memory, and epigenetic stability. Parisha completed a Postdoctoral Research Fellowship at the University of Pennsylvania, Epigenetics Institute where she studied epigenetics of senescence, aging, and age-related disease. Parisha received her BS from Juniata College and her PhD from The University of Chicago, where she studied mechanisms of recombinase function during homologous recombination and DNA repair. Parisha is a member of the Penn Genetics Gender Equity Group, serves on the Board of Trustees of Juniata College, and is an advocate for evolving scientific curricula and improving public science education.

Collection Overview

Transformational advances in technology have greatly expanded our understanding of epigenetic states, histone modifications, and genome organization. This collection highlights cutting-edge methods that enable epigenetic analysis with fewer cells, greater clarity, and higher resolution. These approaches are highly complementary, with each offering distinct strengths and capabilities. Together, they provide a synergistic toolkit for interrogating epigenetic regulation across diverse biological contexts. Accordingly, this collection aims to equip researchers with a versatile suite of methodologies to address a broad range of questions related to epigenetic states, integrating both population-based and single-cell strategies to overcome the limitations of individual approaches and maximize experimental insight.