Login processing...

Trial ends in Request Full Access Tell Your Colleague About Jove
Methods Collections

Current methods for investigating the complications of diabetes

COVID-19 response: Video production in affected areas is postponed, publishing text articles first

JoVE will publish text articles after the peer review, which on average takes two months after the manuscript submission. We will film and add corresponding videos to our website when laboratories and facilities in affected areas reopen.

Just Started
Methods Collection Image
Methods Collections
Current methods for investigating the complications of diabetes

Guest Editors
Kirsten Riches-Suman

School of Chemistry and Biosciences

Dr. Kirsten Riches-Suman is a Lecturer in Biomedical Science at the University of Bradford. She completed her PhD in...

Romana Mughal

School of Applied Sciences

Dr Romana Mughal is a lecturer in the department of Optometry and Vision Sciences at the University of Huddersfield. She...

Collection Overview

The prevalence of diabetes is growing at an alarming rate, with 1 in 11 members of the adult population suffering from the condition globally. In addition to impaired glucose control, patients with diabetes are at a much higher risk of developing complications that affect almost all bodily systems. Diabetic retinopathy, nephropathy, neuropathy, and cardiomyopathy are all well recognized cognate conditions, and patients suffer premature and widespread development of atherosclerosis, leading to heart disease and stroke. Alongside this, patients are more susceptible to infection and have poor wound healing responses, resulting in chronic wounds that can lead to amputation. Whilst advances in glucose control have helped to reduce some of these complications, it is not effective in normalizing all, and further research is necessary in order to design therapeutics to combat these devastating conditions.

Current research into diabetes encompasses clinical, in vivo, ex vivo and in vitro approaches. Each of these models has strengths and weaknesses, and it is likely that any advances in treatment for diabetes complications will come from a combination of multiple models. The present collection will collate the most recent cutting-edge techniques used to assess the establishment, pathogenesis, or treatment of diabetes complications. It will share standardized protocols for preclinical or clinical assessments, including biochemical, histological, or imaging techniques. Altogether, the collection will promote sharing of information that enhances our ability to examine the complications of diabetes in a cross-disciplinary and global manner.

Abstracts

Laser capture microdissection on surgical tissues to identify aberrant gene expression contributing to impaired wound healing in Type 2 diabetes

Rachael Williams*1, Irene Castellano Pellicena2, Stephen Sikkink1, Richard Baker1, Kirsten Riches-Suman*1, Julie Thornton*1
1University of Bradford, 2University College Dublin

Doxycycline Loaded Collagen/Chitosan Composite Scaffold for the Accelerated Healing of Diabetic Wounds

Veera Venkata Satyanarayana Reddy Karri*1, Bharat Kumar Reddy Sanapalli1, Kalaivani C1
1Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Ooty, Nilgiris, Tamilnadu, India-643001

Get cutting-edge science videos from JoVE sent straight to your inbox every month.

Waiting X
simple hit counter