Current methods for investigating the complications of diabetes
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School of Chemistry and Biosciences
Dr. Kirsten Riches-Suman is a Lecturer in Biomedical Science at the University of Bradford. She completed her PhD in...
School of Applied Sciences
Dr Romana Mughal is a lecturer in the department of Optometry and Vision Sciences at the University of Huddersfield. She...
The prevalence of diabetes is growing at an alarming rate, with 1 in 11 members of the adult population suffering from the condition globally. In addition to impaired glucose control, patients with diabetes are at a much higher risk of developing complications that affect almost all bodily systems. Diabetic retinopathy, nephropathy, neuropathy, and cardiomyopathy are all well recognized cognate conditions, and patients suffer premature and widespread development of atherosclerosis, leading to heart disease and stroke. Alongside this, patients are more susceptible to infection and have poor wound healing responses, resulting in chronic wounds that can lead to amputation. Whilst advances in glucose control have helped to reduce some of these complications, it is not effective in normalizing all, and further research is necessary in order to design therapeutics to combat these devastating conditions.
Current research into diabetes encompasses clinical, in vivo, ex vivo and in vitro approaches. Each of these models has strengths and weaknesses, and it is likely that any advances in treatment for diabetes complications will come from a combination of multiple models. The present collection will collate the most recent cutting-edge techniques used to assess the establishment, pathogenesis, or treatment of diabetes complications. It will share standardized protocols for preclinical or clinical assessments, including biochemical, histological, or imaging techniques. Altogether, the collection will promote sharing of information that enhances our ability to examine the complications of diabetes in a cross-disciplinary and global manner.