Waiting
Login processing...

Trial ends in Request Full Access Tell Your Colleague About Jove
Methods Collections

iNEXT-Discovery: Integrating High-end Facilities for Translational Research in Structural Biology

Methods Collection Image
Methods Collections
iNEXT-Discovery: Integrating High-end Facilities for Translational Research in Structural Biology

Guest Editors
Anastassis Perrakis

Netherlands Cancer Institute

Dr. Anastassis Perrakis is a Group Leader in Structural Biology in the Division of Biochemistry at the Netherlands Cancer …

Hans Wienk

Netherlands Cancer Institute

Dr. Hans Wienk is a Project Manager in the Division of Biochemistry at the Netherlands Cancer Institute (NKI) in…

Collection Overview

Integrative structural biology uses a large variety of biophysical methods that provide detailed knowledge of the atomic and molecular structure of macromolecules, isolated or in their native environment. This provides a better understanding of the basic of chemistry of life and helps with the development of new biotechnology tools, drugs, and biomaterials. Access to large-scale installations (synchrotrons producing X-rays, state-of-the-art electron microscopes, powerful NMR magnets) is necessary for research in structural biology. This Methods Collection will describe the most important methods for the structural analysis of macromolecules, applications in fragment-based lead drug discovery, methods to investigate the structure of macromolecules in their native environment, and high throughput approaches for structural determination. It will consist of a variety of methods that includes, but is not limited to, NMR, cryo-EM, X-ray crystallography, and scattering.

Articles

Get cutting-edge science videos from JoVE sent straight to your inbox every month.

Waiting X
Simple Hit Counter