Icahn School of Medicine at Mount Sinai
Stroke is the second leading cause of death and disability worldwide. Animal stroke models are important in studying the causative mechanisms of stroke as well as to investigate novel treatments. However, the different causes and biomarkers of stroke make it difficult to study and discover treatments. Animal models of stroke are essential in understanding stroke etiology and pathology and provide insight into the appropriate application for research of new therapeutic interventions.
This proposed collection will bring together a wide range of relevant animal stroke models, evaluated systematically based on outcomes, to help researchers develop appropriate applications for scientific and clinical discoveries. Stroke will be evaluated in animals using a variety of techniques including: behavior assays, MRI, and immunohistochemisty. This will provide qualitative and quantitative information about the mechanisms of stroke induced injuries as well as the therapeutic potential of identified drugs for treatment. Animal models will include; induced ischemic stroke using middle cerebral artery occlusion, intracerebral hemorrhage using autologous blood or collagenases injection, subarachnoid hemorrhage (SAH) using injection of autologous blood into the cisterna magna, aneurysmal SAH (aSAH) using artery puncture or blood injection and a blast induced multi-brain bleeding model. Intervention outcomes will be assessed using MRI, behavior testing, and immunohistochemistry.