Intraoperative cancer imaging
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Louisiana State University
Dr. Jian Xu is an assistant professor in Louisiana State University. He received his Ph.D. degree in Electrical…
Cancer is the most common cause of death in the economically developed world and the second most common cause in the less developed world. Surgery is the most effective treatment for patients with localized solid tumors. A major challenge in cancer surgery is the inability to remove all existing tumor. Local recurrence rates approach 40% following tumor resection within five years of resection. Local recurrences may be associated with worse survival. Complete tumor removal at the first operation may result in better survival; for instance, the 5-year survival rate for pancreatic cancer is threefold higher in the complete resection than in the incomplete one. Intraoperative-frozen-section-analysis (IFSA)-aided surgical judgment is the state-of-the-art method to aid in the complete resection in cancer surgery. However, IFSA is inefficient and expensive.: only several points in tissues can be analyzed and due to the non-optimal sample preparation, the diagnosis accuracy by IFSA is significantly worse than that of formalin fixed paraffin embedded tissue procedure, which can only be performed several hours to days after surgery.
To address this challenge, multiple intraoperative imaging modalities, such as fluorescence imaging and Raman spectroscopic imaging, are being actively developed to help the surgeon determine if the tumor has been completely removed in surgery. This Methods Collection covers the topics in the field of intraoperative cancer imaging; including, but not limited to, the design of novel contrast agents, the development of sensitive bioinstrumentation, and the advancement of various image-guided cancer surgeries.