Affiliation: Weill Cornell Medicine, Brain and Mind Research Institute

Manu Sharma, Ph.D. is an Assistant Professor of Neuroscience in the Feil Family Brain and Mind Research Institute at Weill Cornell Medicine. He obtained his Ph.D. in Laboratory Medicine and Pathobiology from University of Toronto and the Hospital for Sick Children in Canada. For his thesis work he studied trafficking and turnover of the cystic fibrosis protein CFTR, and how its loss of function due to disease-related mutations can be rescued by small chemicals called chemical chaperones. As a post-doctoral fellow at UT Southwestern and Stanford University, he studied the function of two neurodegeneration-related synaptic proteins - alpha-synuclein and cysteine string protein-alpha. In 2014, he established his lab at Weill Cornell Medicine, where he aims to understand proteostasis mechanisms of aggregation-prone proteins which cause neurodegeneration in aging diseases such as Alzheimer’s disease and Parkinson’s disease.