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Genetics
DNA Methylation and Gene Silencing
Description
DNA methylation is a DNA change that can help turn genes on or off. It happens most often at CpG dinucleotides, which are places where a cytosine is followed by a guanine in the DNA sequence. Methyl groups added at these sites may affect gene expression and are often studied near promoters and other gene control regions.
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Transcript
DNA-methylatie is een chemische modificatie van DNA die de genexpressie beïnvloedt onder verschillende cellulaire contexten. Veel onderzoekers zijn geïnteresseerd in het mechanisme en de functies van dit proces, omdat afwijkende DNA-methylatie is geassocieerd met ziekten zoals kanker.
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