Biomems
Biomems - Related Videos
08:28
Overview of BioMEM Devices
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2023
Bio-microelectromechanical systems, also called BioMEMs, are microscale devices that enable the use of small sample and reagent volumes for diagnostic devices in vivo and in vitro. These devices perform various functions such as filtration, sensing, or synthesis on the microscale, enabling cost savings and improved sensitivity. This video introduces BioMEMs, touches on their use in the bioengineering field, and presents some prominent methods used in fabrication. Additionally, this video...
16:30
BioMEMS and Cellular Biology: Perspectives and Applications
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Cited by 3 •
2007
The ability to culture cells has revolutionized hypothesis testing in basic cell and molecular biology research. It has become a standard methodology in ...
07:26
BioMEMS: Forging New Collaborations Between Biologists and Engineers
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Cited by 1 •
2007
This video describes the fabrication and use of a microfluidic device to culture central nervous system (CNS) neurons. This device is compatible with ...
07:44
Microfabrication via Photolithography
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2023
The fabrication of BioMEM devices is often done using a microfabrication technique called photolithography. This widely used method utilizes light to transfer a pattern onto a silicon wafer, and provides the basis for the fabrication of many types of BioMEM devices. This video presents the photolithography technique, shows how the process is performed in the cleanroom, and introduces some applications of the process.
07:40
Microstructured Devices for Optimized Microinjection and Imaging of Zebrafish Larvae
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Cited by 8 •
2017
Microinjection of zebrafish embryos and larvae is a crucial but challenging technique used in many zebrafish models. Here, we present a range of microscale tools to aid in the stabilization and orientation of zebrafish for both microinjection and imaging.
FAQs
Microfluidic structures guide small fluid volumes so biological samples or reagents can interact under controlled conditions. Sensors then detect biochemical or biophysical changes and translate them into electrical or optical signals. This integration links sample handling with measurement, allowing a BioMEMS device to produce analytical results without requiring separate large-scale fluid-processing and detection systems.
Microfluidics controls the movement and handling of very small fluid volumes within the device. That control can reduce sample and reagent requirements while supporting rapid analysis. In bioengineering, it also helps organize interactions between biological materials and sensing elements, creating a compact platform for diagnostics, cell analysis, and other tasks that depend on reproducible fluid handling.
Each component contributes a different function rather than operating independently. Fluidic elements manage samples, mechanical features support physical manipulation, biological components provide the relevant interaction, and electrical or optical elements detect the resulting change. Combining these functions on one miniaturized platform enables BioMEMS to analyze or manipulate living systems in an integrated workflow.
Miniaturization can lower the amounts of samples and reagents needed and can shorten measurement time. It also supports portable formats, which are useful when testing or analysis must occur outside conventional laboratory settings. In bioengineering, these characteristics help connect compact device design with point-of-care testing and minimally invasive technologies.
A general workflow places a biological sample or reagent within the device, uses microfluidic features to control its movement or contact, and monitors the resulting biochemical or biophysical interaction. Integrated sensors convert that interaction into an electrical or optical signal. The measured output can then support applications such as rapid diagnostics or cell analysis.
BioMEMS are useful for point-of-care testing when rapid results, limited sample and reagent use, and portability are important. Their integrated fluid handling and sensing functions can support analysis in a compact format rather than relying entirely on larger laboratory systems. This makes them relevant to developing faster, more accessible diagnostic technologies.
In drug delivery, BioMEMS can support controlled handling or release of therapeutic materials. For cell analysis, they provide compact systems for examining biological cells, while tissue-engineering applications use them to help manipulate or study living biological systems. These uses illustrate how the same integration of microfabrication, microfluidics, and sensing can address different bioengineering objectives.