Human Vascular Network
Human Vascular Network - Related Videos
03:33
Visualization of Neural and Vascular Networks in a Chicken Embryo
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2025
Source: Delalande, J., et.al. Dual Labeling of Neural Crest Cells and Blood Vessels Within Chicken Embryos Using ChickGFP Neural Tube Grafting and Carbocyanine Dye DiI Injection. J. Vis. Exp. (2015)This video demonstrates the transplantation of a GFP-labeled donor neural tube from a stage-matched transgenic chicken embryo into a recipient embryo at the level of somites one to seven, followed by vascular labeling using a lipophilic fluorescent dye. The combined approach allows for direct...
10:53
Image-guided, Laser-based Fabrication of Vascular-derived Microfluidic Networks
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Cited by 10 •
2017
This protocol outlines the implementation of image-guided, laser-based hydrogel degradation to fabricate vascular-derived, biomimetic microfluidic networks embedded in poly(ethylene glycol) diacrylate (PEGDA) hydrogels. These biomimetic microfluidic systems may be useful for tissue engineering applications, generation of in vitro disease models, and fabrication of advanced "on-a-chip" devices.
06:55
Bioengineering Human Microvascular Networks in Immunodeficient Mice
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Cited by 21 •
2011
Here, we describe a methodology to deliver human cord blood-derived endothelial colony-forming cells (ECFCs) and bone marrow-derived mesenchymal stem cells (MSCs), embedded in a collagen/fibronectin gel, subcutaneously into immunodeficient mice. This cell/gel combination generates a human vascular network that connects with the mouse vasculature.
09:33
Three-dimensional Rendering and Analysis of Immunolabeled, Clarified Human Placental Villous Vascular Networks
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Cited by 12 •
2018
This study presents a protocol for the reversible tissue clearing, immunostaining, 3D-rendering and analysis of vascular networks in human placenta villi samples on the order of 1 - 2 mm3.
07:05
Perfusable Vascular Network with a Tissue Model in a Microfluidic Device
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Cited by 10 •
2018
The protocol describes how to engineer a perfusable vascular network in a spheroid. The spheroid's surrounding microenvironment is devised to induce angiogenesis and connect the spheroid to the microchannels in a microfluidic device. The method allows the perfusion of the spheroid, which is a long-awaited technique in three-dimensional cultures.
FAQs
Changing vessel diameter alters how much blood moves through a region and contributes to blood-pressure regulation. The same adjustment can help control temperature and preserve tissue homeostasis by redirecting flow as physiological needs change. For biology research, examining diameter alongside blood movement helps explain how the network adapts rather than functioning as a fixed set of tubes.
Capillaries provide the exchange interface because their walls are thin enough to permit movement of oxygen, nutrients, and metabolic waste between blood and surrounding tissues. Their position between arterioles and venules places them after incoming arterial flow and before venous return. This makes capillary structure essential when investigating whether tissues receive supplies and remove waste effectively.
Arteries and arterioles carry blood toward capillary regions, where exchange with tissues occurs; venules and veins then carry blood away from those regions. This ordered arrangement separates delivery, exchange, and return within one connected pathway. Studying each segment helps biologists relate vessel location to its contribution to tissue supply and metabolic waste removal.
A focused investigation can compare the route through arteries, arterioles, capillaries, venules, and veins, then examine how flow and vessel diameter relate to blood pressure, temperature regulation, and tissue homeostasis. Researchers can also consider whether capillary exchange supports oxygen and nutrient delivery while removing metabolic waste. These observations connect vascular structure with physiological outcome.
The network directly participates in blood circulation and blood-pressure regulation, so changes in its structure or function can be examined in relation to cardiovascular disease. Biology studies can assess how altered flow, vessel diameter, or exchange may affect tissue supply and homeostasis. This knowledge supports investigation of disease mechanisms and possible treatments.
Tumor growth and wound healing both make blood supply an important research concern. Investigators study the vascular network to understand how circulation reaches affected tissues and how supply may be restored or controlled. Findings can guide treatment development aimed at changing blood availability, while also connecting local vascular behavior with broader tissue homeostasis.