Pulmonary Disease Model
Pulmonary Disease Model - Related Videos
08:17
Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure
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Cited by 7 •
2017
This study describes the successful generation of a new chronic obstructive pulmonary disease (COPD) animal model by repeatedly exposing mice to high concentrations of ozone.
09:40
Hemodynamic Characterization of Rodent Models of Pulmonary Arterial Hypertension
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Cited by 35 •
2016
Pulmonary arterial hypertension (PAH) is a disease of pulmonary arterioles that leads to their obliteration and the development of right ventricular failure. Rodent models of PAH are critical in understanding the pathophysiology of PAH. Here we demonstrate hemodynamic characterization, with right heart catheterization and echocardiography, in the mouse and rat.
10:56
Transplantation of Pulmonary Valve Using a Mouse Model of Heterotopic Heart Transplantation
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Cited by 7 •
2014
In order to understand the cellular and molecular mechanisms underlying neotissue formation and stenosis development in tissue engineered heart valves, a murine model of heterotopic heart valve transplantation was developed. A pulmonary heart valve was transplanted to recipient using the heterotopic heart transplantation technique.
01:24
Chronic Obstructive Pulmonary Disease
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2026
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction. Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
09:23
Shunt Surgery, Right Heart Catheterization, and Vascular Morphometry in a Rat Model for Flow-induced Pulmonary Arterial Hypertension
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Cited by 15 •
2017
This protocol describes a surgical procedure to create a model for flow-induced pulmonary arterial hypertension (PAH) in rats and the procedures to analyze the principle hemodynamic and histological end-points in this model.
FAQs
They provide controlled settings for examining interactions among lung cells, immune mediators, and infectious agents. By focusing on these components within a defined experimental system, investigators can study how respiratory disease develops, how inflammation and tissue injury arise, and how protective immune responses are generated. This helps connect host-pathogen interactions with observable changes in lung function or tissue behavior.
Cultured airway or alveolar cells, organoids, animal systems, and engineered tissues reproduce different aspects of lung structure, function, or disease. Their value depends on the feature under investigation: a model may emphasize individual cell behavior, tissue organization, whole-organism responses, or engineered lung characteristics. Using more than one system can provide complementary perspectives on the same disorder.
These models support investigation of inflammation, tissue injury, protective immunity, and host-pathogen interactions. They can show how lung cells respond to infectious agents and how immune mediators participate in respiratory disease. In immunology and infection research, this makes it possible to connect cellular and tissue-level responses with broader questions about disease development and immune protection.
Controlled conditions allow investigators to examine selected lung, immune, or infectious components within an experimental system rather than relying only on observations from patients or whole organisms. This supports focused analysis of disease mechanisms and treatment responses. The resulting findings can complement studies in patients and whole organisms, while keeping the investigated interactions within a defined model context.
A study begins by selecting a system that reproduces the relevant lung structure, function, or disease feature, such as airway cells, alveolar cells, organoids, engineered tissue, or an animal system. Investigators then examine relevant interactions among lung cells, immune mediators, and infectious agents under controlled conditions, using the model to assess disease processes or responses to treatment.
These systems provide experimental settings in which responses to vaccines or therapeutics can be investigated in relation to respiratory disease. Researchers can examine whether an intervention affects host-pathogen interactions, inflammation, tissue injury, or protective immune responses. Such evidence supports treatment and vaccine evaluation while complementing research conducted in patients and whole organisms.