Multimodal Molecular Imaging
Multimodal Molecular Imaging - Related Videos
11:28
Biofunctionalized Prussian Blue Nanoparticles for Multimodal Molecular Imaging Applications
0 Views •
Cited by 17 •
2015
This protocol describes the synthesis of biofunctionalized Prussian blue nanoparticles and their use as multimodal, molecular imaging agents. The nanoparticles have a core-shell design where gadolinium or manganese ions within the nanoparticle core generate MRI contrast. The biofunctional shell contains fluorophores for fluorescence imaging and targeting ligands for molecular targeting.
09:43
In vivo Near Infrared Fluorescence (NIRF) Intravascular Molecular Imaging of Inflammatory Plaque, a Multimodal Approach to Imaging of Atherosclerosis
0 Views •
Cited by 32 •
2011
We detail a new near-infrared fluorescence (NIRF) catheter for 2-dimensional intravascular molecular imaging of plaque biology in vivo. The NIRF catheter can visualize key biological processes such as inflammation by reporting on the presence of plaque-avid activatable and targeted NIR fluorochromes. The catheter utilizes clinical engineering and power requirements and is targeted for application in human coronary arteries. The following research study describes a multimodal imaging strategy...
12:38
4D Multimodality Imaging of Citrobacter rodentium Infections in Mice
0 Views •
Cited by 19 •
2013
Multi-modality imaging is a valuable approach for studying bacterial colonization in small animal models. This protocol outlines infection of mice with bioluminescent Citrobacter rodentium and the longitudinal monitoring of bacterial colonization using composite 3D diffuse light imaging tomography with μCT imaging to create a 4D movie of C. rodentium infection.
10:25
Multimodal Imaging of Stem Cell Implantation in the Central Nervous System of Mice
0 Views •
Cited by 11 •
2012
This article describes an optimized sequence of events for multimodal imaging of cellular grafts in rodent brain using: (i) in vivo bioluminescence and magnetic resonance imaging, and (ii) post mortem histological analysis. Combining these imaging modalities on a single animal allows cellular graft evaluation with high resolution, sensitivity and specificity.
06:54
MR Molecular Imaging of Prostate Cancer with a Small Molecular CLT1 Peptide Targeted Contrast Agent
0 Views •
Cited by 3 •
2013
To demonstrate MR cancer molecular imaging with a small peptide targeted MRI contrast agent specific to clotted plasma proteins in tumor stroma in a mouse prostate cancer model.
FAQs
Targeted molecular probes provide signals that reflect specific biological activity rather than anatomy alone. When paired with an imaging technology that supplies high spatial resolution or functional information, these probes help connect molecular changes to their physical location. This relationship can reveal where disease-related processes occur and support more informed interpretation of otherwise separate imaging findings.
Alignment places signals from multiple imaging sources into a shared anatomical or spatial framework. Without accurate alignment, molecular activity may be difficult to associate with the relevant tissue or lesion. Jointly interpreted, the datasets can show both the location and biological character of disease, improving localization and helping clinicians relate molecular findings to structural context.
A single imaging signal may emphasize anatomy, physiology, or molecular activity, but it may not provide all three perspectives together. Multimodal molecular imaging combines complementary information so that one technology can supply context for another. This broader view may improve disease characterization by linking biological activity with anatomical location rather than interpreting either feature in isolation.
The value of the combination depends on how well the signals answer different parts of the same clinical question. Targeted probes can indicate molecular processes, while another modality may contribute high spatial resolution or functional information. Their usefulness comes from complementarity: the integrated result should clarify disease location, activity, or both more effectively than either signal alone.
A typical workflow begins by acquiring signals from at least two imaging technologies, including information from molecular probes when appropriate. The resulting datasets are then aligned and examined jointly rather than separately. Interpretation focuses on the relationship between molecular activity and anatomy or physiology, producing a combined view that can support localization, characterization, or treatment-related decisions.
Treatment selection may benefit when imaging needs to show both where disease is located and how biologically active it is. Molecular information can help characterize the disease process, while anatomical or physiological information provides context for planning. Together, these findings may help identify a more appropriate therapeutic strategy and establish imaging features that can be followed during care.
Repeated multimodal imaging can compare molecular activity with anatomical or physiological findings across time. A change in biological activity may provide information about response, while the accompanying structural context helps determine where that change occurs. In medicine, this longitudinal perspective can support assessment of treatment effects and contribute to more precise evaluation of disease progression or control.