Foam Cell Formation
Foam Cell Formation - Related Videos
09:41
Quantification of Monocyte Transmigration and Foam Cell Formation from Individuals with Chronic Inflammatory Conditions
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Cited by 17 •
2017
We describe a protocol to measure transmigration by monocytes across human endothelial monolayers and their subsequent maturation into foam cells. This provides a versatile method to assess the atherogenic properties of monocytes isolated from people with different disease conditions and to evaluate factors in blood which may enhance this propensity.
07:56
Preparation of Carbon Fiber and Bamboo Fiber Reinforced Poly (butylene Adipate-co-terephthalate) Foams by Supercritical Carbon Dioxide Foaming
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2025
This study describes a supercritical carbon dioxide foaming method for the preparation of carbon fiber and bamboo fiber reinforced poly (butylene adipate-co-terephthalate) foams.
13:38
Synthesis of Biocompatible Liquid Crystal Elastomer Foams as Cell Scaffolds for 3D Spatial Cell Cultures
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Cited by 9 •
2017
This study presents a methodology to prepare 3D, biodegradable, foam-like cell scaffolds based on biocompatible side-chain liquid crystal elastomers (LCEs). Confocal microscopy experiments show that foam-like LCEs allow for cell attachment, proliferation, and the spontaneous alignment of C2C12s myoblasts.
09:22
Casting Protocols for the Production of Open Cell Aluminum Foams by the Replication Technique and the Effect on Porosity
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Cited by 22 •
2014
Replication is one of the processing techniques used for the production of porous metal sponges. In this paper one implementation of the method for the production of open celled porous aluminum is shown in detail.
11:19
Fabrication of Extracellular Matrix-derived Foams and Microcarriers as Tissue-specific Cell Culture and Delivery Platforms
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Cited by 26 •
2017
The tissue-specific extracellular matrix (ECM) is a key mediator of cell function. This article describes methods for synthesizing pure ECM-derived foams and microcarriers that are stable in culture without the need for chemical crosslinking for applications in advanced 3D in vitro cell culture models or as pro-regenerative bioscaffolds.
FAQs
Scavenger receptors enable macrophages and other vascular cells to take up modified low-density lipoprotein, or LDL, within the arterial wall. This uptake supplies the lipid burden that can become stored inside cells. Because the process contributes to intracellular lipid accumulation, scavenger receptor activity is an important focus for understanding how atherosclerotic plaques develop.
Cholesterol efflux normally helps move cholesterol out of cells. When this process is disrupted, lipid remains inside macrophages and other vascular cells, where it can accumulate as lipid droplets and cholesteryl esters. This imbalance between lipid uptake and removal helps explain why cells become increasingly lipid-loaded during plaque development.
Lipid-loaded cells can release inflammatory mediators that alter the local arterial environment. Their activity may therefore contribute not only to plaque growth but also to changes in plaque stability. Studying this connection links intracellular lipid storage with vascular inflammation and helps researchers examine how cellular behavior affects the progression of atherosclerotic disease.
Foam Cell Formation connects modified LDL uptake, impaired cholesterol efflux, intracellular lipid storage, and inflammatory signaling within the arterial wall. Examining these linked events provides a cellular explanation for processes associated with atherosclerotic plaque development. This perspective complements broader clinical research focused on cardiovascular disease and its underlying vascular changes.
The process identifies several points that lipid-lowering strategies may address, including the accumulation of modified LDL and the storage of cholesterol inside vascular cells. Research can use these mechanisms to evaluate approaches intended to reduce lipid burden or improve cholesterol handling. Such work supports efforts to prevent or treat atherosclerosis through altered lipid biology.
Studies of foam cell biology support research into cholesterol transport, vascular inflammation, lipid-lowering therapies, and strategies for preventing or treating atherosclerosis. These areas are connected because lipid movement and storage can influence inflammatory activity and plaque behavior. Together, they provide a framework for investigating how cellular mechanisms relate to cardiovascular outcomes.