Neuroimmunology Research
Neuroimmunology Research - Related Videos
10:30
High-resolution Confocal Imaging of the Blood-brain Barrier: Imaging, 3D Reconstruction, and Quantification of Transcytosis
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Cited by 11 •
2017
Here we present a microscopy-based protocol for high-resolution imaging and a three-dimensional reconstruction of the mouse neurovascular unit and blood-brain barrier using brain free-floating sections. This method allows for the visualization, analysis, and quantification of intracellular organelles at the BBB.
08:04
Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro
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Cited by 8 •
2014
The protocol reported here allows the evaluation of the efficacy of photodynamic therapy (PDT) in cell lines and the optimization of the PDT settings before applying the therapy in animal models.
09:11
Immunohistochemical Analysis in the Rat Central Nervous System and Peripheral Lymph Node Tissue Sections
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Cited by 8 •
2016
We here present an optimized, detailed protocol for double immunostaining in formalin-fixed, paraffin-embedded rat central nervous system (CNS) and peripheral lymph node (LN) tissue sections.
10:01
Structure-Guided Design and Development of Novel Cyclophilin A Inhibitors and Ganoderiol-F Derivatives: An In-Silico Approach
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2026
Here, we present a protocol for the structure-guided design of protein-ligand binding interaction between Sanglifehrin A and Cyclophilin A/Ganoderiol-F, essential in discovering new drugs. The stability of the ligand-receptor complex was evaluated using molecular dynamics simulation.
06:09
Rapid Isolation of Single Cells from Mouse and Human Teeth
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Cited by 3 •
2021
The current protocol presents a fast, efficient, and gentle method for isolating single cells suitable for single-cell RNA-seq analysis from a continuously growing mouse incisor, mouse molar, and human teeth.
FAQs
Cytokine signaling provides a communication route through which immune activity can affect neural function. During infection or inflammation, changes in these signals may help explain alterations involving the brain and spinal cord. Studying the signaling patterns can therefore connect immune responses with neurological effects and identify mechanisms that may be relevant to infection-associated neurological disorders.
Microglial activation is an important cellular response examined in neuroimmunology research because it links immune activity within nervous tissue to inflammatory processes. Researchers assess how this activation relates to infection and neural dysfunction, particularly when immune responses affect the brain or spinal cord. These relationships can inform the study of inflammatory disease mechanisms and potential anti-inflammatory strategies.
Leukocyte trafficking across the blood-brain barrier helps researchers examine how immune cells move between the circulation and nervous tissue. This process is especially relevant when investigating infections or inflammatory conditions that affect the brain and spinal cord. Understanding the trafficking response can clarify how immune activity reaches neural sites and contributes to neurological consequences.
A research framework can follow the relationship between a pathogen, the resulting immune response, and changes in neural function. Viral and bacterial infections are particularly important contexts because immune responses to these pathogens can affect the brain and spinal cord. This connection helps explain infection-associated neurological disorders and identifies points where immune or inflammatory interventions may act.
These studies can generate evidence for biomarkers, which are measurable indicators associated with disease or biological activity, and can clarify mechanisms of neuroimmune dysfunction. In infection research, the findings may also support vaccine development, anti-inflammatory strategies, and treatments for neurological disorders associated with infection. The outcomes link mechanistic discovery with potential clinical and translational priorities.
It broadens infection research beyond the pathogen and immune response alone by examining effects on neural tissues and reciprocal regulation by neural signals. This perspective helps explain how viruses, bacteria, and inflammatory processes influence the brain and spinal cord. It also supports investigation of disorders in which infection, immunity, and nervous-system function are closely connected.