Cisplatin Treatment
Cisplatin Treatment - Related Videos
04:04
Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
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Cited by 13 •
2017
The management of isolated recurrent lung cancer in a previously-irradiated field is challenging. Here, we describe an endobronchial ultrasound (EBUS)-guided cisplatin injection for the management of patients with localized lung cancer recurrence in a previously-radiated field.
06:32
Operating Procedures of the Electrochemotherapy for Treatment of Tumor in Dogs and Cats
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Cited by 45 •
2016
Electrochemotherapy is the local treatment of solid tumors. The main mechanism is electroporation-mediated permeabilization of the tumor cells' membrane which enables increased internalization of cytostatics like bleomycin and cisplatin. Thus, antitumor effectiveness is potentiated at the site of the application of electric pulses to the tumors.
07:47
Custom-designed Laser-based Heating Apparatus for Triggered Release of Cisplatin from Thermosensitive Liposomes with Magnetic Resonance Image Guidance
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Cited by 17 •
2015
AN MRI-compatible custom-designed laser-based heating apparatus has been developed to provide local heating of subcutaneous tumors in order to activate release of agents from thermosensitive liposomes specifically at the tumor region.
13:25
Acute Kidney Injury Model Induced by Cisplatin in Adult Zebrafish
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Cited by 10 •
2021
This protocol describes the procedures to induce Acute Kidney Injury (AKI) in adult zebrafish using cisplatin as a nephrotoxic agent. We detailed the steps to evaluate the reproducibility of the technique and two techniques to analyze inflammation and cell death in the renal tissue, flow cytometry and TUNEL, respectively.
11:39
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
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Cited by 26 •
2013
Psoriasis is a chronic, immune-mediated inflammatory skin disease. The Goeckerman regimen, formulated for the treatment of psoriasis, consists of exposure to ultraviolet B (UVB) light and application of crude coal tar (CCT). The following protocol is for the administration of Goeckerman therapy for the treatment of moderate-to-severe psoriasis.
FAQs
Once cisplatin enters a cell, it forms covalent bonds with DNA. These bonds can connect bases within one DNA strand region, creating an intrastrand crosslink, or link opposite strands as an interstrand crosslink. Both distort DNA architecture, preventing normal access needed for replication and transcription.
Blocking replication and transcription deprives the cell of essential DNA-copying and gene-expression processes. This damage can activate pathways that culminate in cell death. The mechanism therefore links a molecular lesion, DNA crosslinking, directly to the intended anticancer outcome: inhibition or elimination of rapidly dividing cancer cells.
The treatment can be effective against tumors, yet its use may produce kidney damage, hearing loss, nerve injury, and suppression of blood-cell production. Because these effects can limit safe treatment, clinicians incorporate dose adjustment and monitoring rather than considering tumor control alone. This balance is central to medical use of cisplatin in practice.
Hydration is a key supportive measure during cisplatin treatment because it is identified as essential when managing the drug’s potential kidney damage. It is used alongside dose adjustment and patient monitoring, not as a replacement for anticancer therapy. This coordinated approach helps clinicians balance administration with kidney safety in medical practice.
Clinicians use cisplatin treatment across several tumor types, including testicular, ovarian, bladder, lung, and head and neck cancers. The range shows that its clinical role is not confined to one organ system. In each setting, treatment selection still requires attention to toxicity, dose adjustment, hydration, and monitoring.
It may be administered alone or combined with other therapies, depending on the clinical treatment plan. Combination use allows cisplatin to serve as one component of a broader anticancer strategy, while its characteristic toxicities remain relevant. Regardless of the regimen, clinicians must monitor the patient and adjust dose or hydration as needed.