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Acute Kidney Injury Model Induced by Cisplatin in Adult Zebrafish
JoVE Journal
Medicine
Author Produced
This content is Free Access.
JoVE Journal Medicine
Acute Kidney Injury Model Induced by Cisplatin in Adult Zebrafish

Acute Kidney Injury Model Induced by Cisplatin in Adult Zebrafish

5,190 Views

13:25 min

May 15, 2021

DOI:

13:25 min
May 15, 2021

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Summary

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This protocol describes the procedures to induce Acute Kidney Injury (AKI) in adult zebrafish using cisplatin as a nephrotoxic agent. We detailed the steps to evaluate the reproducibility of the technique and two techniques to analyze inflammation and cell death in the renal tissue, flow cytometry and TUNEL, respectively.

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