Pmma Spacer
Pmma Spacer - Related Videos
04:54
Solvent Bonding for Fabrication of PMMA and COP Microfluidic Devices
0 Views •
Cited by 30 •
2017
Solvent bonding is a simple and versatile method for fabricating thermoplastic microfluidic devices with high quality bonds. We describe a protocol to achieve strong, optically clear bonds in PMMA and COP microfluidic devices that preserve microfeature details, by a judicious combination of pressure, temperature, an appropriate solvent, and device geometry.
08:51
Genotyping of Staphylococcus aureus by Ribosomal Spacer PCR (RS-PCR)
0 Views •
Cited by 9 •
2016
Here, ribosomal spacer PCR (RS-PCR) is used together with a miniaturized electrophoresis system as a fast and high resolution method for genotyping S. aureus at moderate costs allowing a high throughput.
13:44
Simulation, Fabrication and Characterization of THz Metamaterial Absorbers
0 Views •
Cited by 6 •
2012
This protocol outlines the simulation, fabrication and characterization of THz metamaterial absorbers. Such absorbers, when coupled with an appropriate sensor, have applications in THz imaging and spectroscopy.
11:57
Fabricating Metamaterials Using the Fiber Drawing Method
0 Views •
Cited by 23 •
2012
Metamaterials at terahertz frequencies offer unique opportunities, but are challenging to fabricate in bulk. We adapt the fabrication procedure for microstructured polymer optical fibers to inexpensively fabricate metamaterials potentially on an industrial scale. We produce polymethylmethacrylate fibers containing ~10 μm diameter indium wires separated by ~100 μm, which exhibit a terahertz plasmonic response.
06:03
Electrical Stimulation-Induced Differentiation of Neural Stem and Progenitor Cells
0 Views •
2025
This video demonstrates the use of an extracellular matrix-coated microfluidic chip to differentiate neural stem and progenitor cells or NPCs through electrical stimulation. After seeding and adhering to the coated region, NPCs grow, and the application of a direct current triggers their differentiation into neurons, astrocytes, and oligodendrocytes.
FAQs
Antibiotic loading gives the spacer a drug-delivery role in addition to its structural role. After implantation, the antibiotic diffuses from the cement into surrounding tissue, creating local antimicrobial exposure at the surgical site. This dual action is central to staged infection management: the device occupies the space while the loaded cement supports treatment before definitive reconstruction.
Greater antibiotic content may support elution, but spacer design cannot be judged by drug release alone. The cement must remain sufficiently functional as it preserves joint alignment, limb length, and soft-tissue tension. Biocompatibility is another constraint, so the selected design balances local antimicrobial delivery, mechanical performance, and tissue compatibility rather than optimizing one property in isolation.
By occupying the surgical site, the spacer helps maintain the geometry needed for later reconstruction. In particular, it can preserve joint alignment, limb length, and soft-tissue tension while infection treatment proceeds. These mechanical effects provide a temporary bridge between prosthesis removal and definitive reconstruction, rather than serving only as a carrier for antibiotics.
They are commonly used after surgeons remove an infected joint prosthesis during the first stage of a two-stage revision arthroplasty. An antibiotic-loaded device can then occupy the surgical site while infection management continues. Once infection control permits definitive reconstruction, the temporary spacer's role ends and the joint can proceed to the next reconstructive stage.
Preparation centers on shaping moldable PMMA bone cement for the surgical site and incorporating antibiotics into the cement when local delivery is part of treatment. The resulting design must fit the temporary mechanical purpose while allowing drug diffusion into surrounding tissue. Choice of shape and antibiotic content therefore connects the operative goal with elution, strength, and biocompatibility requirements.
Because it is used between prosthesis removal and definitive reconstruction, the spacer is designed for an interim role rather than permanent joint replacement. Its value lies in maintaining space and selected mechanical relationships while local antimicrobial treatment takes place. This staged function allows reconstruction to be deferred until infection control permits the next procedure.