Neurological Disorder Diagnosis

Neurological disorder diagnosis is the systematic identification of diseases affecting the brain, spinal cord, peripheral nerves, or muscles, enabling appropriate care and research. Clinicians combine medical history, neurological examination, and targeted tests to relate symptoms such as weakness, sensory loss, seizures, or cognitive changes to disrupted nervous system structure or function; magnetic resonance imaging, computed tomography, electroencephalography, electromyography, laboratory analysis, and genetic testing can provide complementary evidence. In neuroscience, this process distinguishes conditions with overlapping symptoms, supports prognosis and treatment selection, and improves understanding of disease mechanisms. Standardized diagnostic approaches also advance clinical trials and the development of biomarkers and therapies.

Neurological Disorder Diagnosis - Related Videos

Research

JoVE Journal - Neuroscience

Measuring Progressive Neurological Disability in a Mouse Model of Multiple Sclerosis

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Cited by 21 •

2016

An optimized testing protocol is presented in this paper for the Rotarod performance test, used for measuring progressive neurological disability in TMEV-infected mice.

Testing Acetylcholine Followed by Adenosine for Invasive Diagnosis of Coronary Vasomotor Disorders

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Cited by 6 •

2021

Coronary vasomotion disorders represent frequent functional causes of angina in patients with unobstructed coronaries. The underlying mechanism of angina (endotype) in these patients can be determined by a comprehensive invasive diagnostic procedure based on acetylcholine provocation testing followed by Doppler-derived assessment of the coronary flow reserve and microvascular resistance.

Quantitative Analysis of Climbing Defects in a Drosophila Model of Neurodegenerative Disorders

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Cited by 119 •

2015

We present an optimized inexpensive and reliable negative geotaxis assay in Drosophila melanogaster as a model for neurodegenerative disorders. Being more sensitive to mild locomotor defects, this assay will help screen for potential genetic interactions and drug targets.

Research

JoVE Journal - Behavior
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A Computer-Based Platform for Aiding Clinicians in Eating Disorder Analysis and Diagnosis

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2022

Diagnosing eating disorders in healthcare is challenging. Therefore, the present protocol develops an algorithm based on 949 patient responses to a questionnaire, with the diagnosis displayed on an easy-to-use web-based interface. This system facilitates the accurate diagnosis of eating disorders while excluding those believed to have an eating disorder.

Research

JoVE Journal - Medicine
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FISH for Pre-implantation Genetic Diagnosis

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Cited by 17 •

2011

This article describes the selection of suitable probes for single-cell FISH, spreading techniques for blastomere nuclei, and in situ hybridization and signal scoring, applied to pre-implantation genetic diagnosis (PGD) in a clinical setting.

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