Generalized Psychophysiological Interaction (PPI) Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease

Theresa M. Harrison; Donald G. McLaren; Teena D. Moody; Jamie D. Feusner; Susan Y. Bookheimer

doi:10.3791/55394

Análise de interação psicofisiológicos generalizada (PPI) de memória relacionados com a conectivi...

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JoVE Journal Neuroscience

Generalized Psychophysiological Interaction (PPI) Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer’s Disease

Análise de interação psicofisiológicos generalizada (PPI) de memória relacionados com a conectividade em indivíduos em risco genético para a doença de Alzheimer

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09:38 min

November 14, 2017

DOI: 10.3791/55394-v

Theresa M. Harrison¹, Donald G. McLaren², Teena D. Moody¹, Jamie D. Feusner¹, Susan Y. Bookheimer¹

¹Psychiatry and Biobehavioral Sciences,University of California, Los Angeles, ²Biospective, Inc.

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Overview

This manuscript describes a psychophysiological interaction analysis aimed at identifying memory-related context-dependent changes in functional connectivity between the hippocampus and other brain regions. This method is particularly useful for examining how functional connectivity varies in response to cognitive demands during tasks.

Key Study Components

Area of Science

Cognitive Neuroscience
Functional Connectivity
Psychophysiological Interaction Analysis

Background

Functional connectivity refers to the temporal correlation between spatially remote neurophysiological events.
Psychophysiological interaction analysis helps in understanding task effects on brain connectivity.
This technique allows researchers to test specific hypotheses regarding brain region connectivity.
It is particularly relevant for studying populations with cognitive decline.

Purpose of Study

To identify changes in functional connectivity related to memory tasks.
To explore how cognitive demands affect connectivity between the hippocampus and other brain regions.
To provide insights into the neural mechanisms underlying cognitive decline.

Methods Used

Participants aged 55 and older with cognitive decline were included.
Subjects were screened for MRI safety and provided informed consent.
A three-tesla MRI system was used for whole brain imaging data acquisition.
Functional imaging involved collecting axial slices using an echo-planar imaging sequence during a memory task.

Main Results

Task-dependent changes in functional connectivity were observed.
Specific brain regions showed altered connectivity patterns in response to cognitive demands.
The findings contribute to understanding the neural basis of cognitive decline.
Results support the utility of psychophysiological interaction analysis in cognitive neuroscience research.

Conclusions

Psychophysiological interaction analysis is effective for studying functional connectivity changes.
This method can enhance our understanding of cognitive processes in aging populations.
Future research can build on these findings to explore interventions for cognitive decline.

Frequently Asked Questions

What is psychophysiological interaction analysis?

It is a method used to examine how task demands affect functional connectivity between brain regions.

Why is this study focused on older adults?

Older adults are often at risk for cognitive decline, making it important to understand changes in brain connectivity.

What imaging technique was used in this study?

A three-tesla MRI system was utilized for whole brain imaging data acquisition.

How does functional connectivity relate to cognitive tasks?

Functional connectivity can change based on the cognitive demands of a task, reflecting how different brain regions communicate.

What are the implications of this research?

The findings can inform interventions aimed at mitigating cognitive decline in aging populations.

Can this method be applied to other populations?

Yes, it can be adapted to study various populations and cognitive conditions.

Este manuscrito descreve como implementar uma análise da interação psicofisiológicos para revelar alterações de tarefas dependentes em conectividade funcional entre uma região de sementes selecionadas e voxels em outras regiões do cérebro. Análise de interação psicofisiológica é um método popular para examinar os efeitos de tarefa na conectividade do cérebro, distinto do tradicional univariada efeitos de ativação.

O objetivo geral desta análise é identificar mudanças dependentes do contexto relacionadas à memória na conectividade funcional entre as regiões do hipocampo e o resto do cérebro. Este método pode ajudar a responder a questões-chave no campo da neurociência cognitiva, como como a conectividade funcional muda em resposta a demandas cognitivas específicas dentro de uma tarefa experimental. A principal vantagem dessa técnica é que ela permite que os pesquisadores testem hipóteses específicas sobre a conectividade funcional de regiões-chave do cérebro durante uma tarefa cognitiva.

Para este experimento, inclua indivíduos com 55 anos ou mais com declínio cognitivo que foram genotipados para o alelo de risco da doença de Alzheimer apolipoproteína E épsilon quatro antes do experimento, rastreie os indivíduos quanto à segurança da ressonância magnética e obtenha consentimento informado. Use um sistema de ressonância magnética de três tesla para adquirir dados de imagens cerebrais completas. Para imagens funcionais, colete cortes axiais usando uma sequência de imagens ecoplanares enquanto executa uma tarefa de memória associativa de palavras não relacionadas.

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