Modelo Multilaboratório da Rede de Avaliação Pré-clínica do AVC Tromboembolico com Trombólise: TE-MCAo

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06:38 min.

19 de dezembro de 2025

932 visualizações

¹Department of Physiology and Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine of USC, ²Department of Neurosurgery, Keck School of Medicine of USC, ³Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, ⁴Department of Internal Medicine, Division of Hematology, Oncology and Blood & Marrow Transplantation, Carver College of Medicine, University of Iowa, ⁵Departments of Neurology & Neurosurgery, Carver College of Medicine, Department of Epidemiology, College of Public Health, University of Iowa, ⁶The Medical College of Georgia at Augusta University, ⁷Department of Anesthesiology, Duke University, ⁸University of California, San Diego, ⁹Department of Neurology, Yale University, ¹⁰Neurovascular Research Unit, Massachusetts General Hospital, ¹¹Laboratory of NeuroImaging, USC Mark and Mary Stevens Neuroimaging and Informatics Institute of the Keck School of Medicine of USC, ¹²Department of Neurology, Keck School of Medicine of USC

Para simular o AVC tromboembólico, êmbolos preparados a partir de sangue heterólogo de rato foram injetados na artéria cerebral média, seguidos pela administração de trombólise sistêmica para recanalização. Esta versão do modelo é otimizada para uso em uma rede multilaboratório e suporta o teste de múltiplos candidatos terapêuticos.