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TOPICAL COLLECTIONS

Current Animal Models of Stroke

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Guest Editors

Rafael Bandeira Fabres

Rafael Bandeira Fabres

Federal University of Rio Grande do Sul and Collaborating Research of Federal University of the ABC, Brazil

Dr. Fabres graduated in Biomedicine (2013) with an emphasis on Clinical Pathology (Clinical Analysis). He completed a master's degree (2016) and a doctorate (2020) in Biological Sciences: Physiology from the Federal University of Rio Grande do Sul (UFRGS). He was a post-doctoral student at the laboratory of cerebral ischemia at UFRGS and was a collaborating researcher at the Federal University of ABC (UFABC). He is currently developing neuroprotective agents in injury models in the neurodevelopmental phase.

Silvia Honda

Silvia Honda

Federal University of the ABC, Brazil

Dr. Honda graduated in Physiotherapy from the University of São Paulo (1997) and worked for nine years at the Association for Assistance to Disabled Children (1998). She completed a master’s degree (2009) and a doctorate (2013) in Morphofunctional Sciences at the Institute of Biomedical Sciences of the University of São Paulo. She was responsible for the adaptation and validation of a non-invasive model of neonatal anoxia in rats and the study of its effects on activation, neuronal death, and hippocampal neurogenesis. She carried out a short internship at the NorthShore University Health System/University of Chicago (Illinois, USA) and was involved in developing research using an animal model of cerebral palsy. She is currently an adjunct professor at the Center for Mathematics, Computing and Cognition at UFABC and accredited in the Postgraduate Program of Neuroscience and Cognition at the same university.

Collection Overview

Today, cerebrovascular disease, including stroke, is the leading cause of morbidity and mortality. It affects around 100 per 100,000 people worldwide. Due to the high prevalence of morbidity caused, stroke is also one of the main events that overload the health system in several countries. On the other hand, hypoxic-ischemic encephalopathy caused by perinatal asphyxia is a public health problem with persistent consequences during development. Therefore, searching for pre-clinical models that mimic its effects more closely than those found in the clinic becomes essential.

The effects of profound systemic hypotension and cerebral ischemia because of cardiac arrest can be mimicked by existing models. While these models mimic global ischemia, the use of focal cerebral ischemia models is preferred to understand the effects of stroke ischemia. The use of pre-clinical models is essential for developing new treatments that can reduce the consequences of these events. Therefore, the purpose of this collection is to demonstrate current standardized protocols that may provide alternatives for the study of event pathophysiology and the wider application of existing methods.

Articles

Transient Middle Cerebral Artery Occlusion Model of Stroke
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Transient Middle Cerebral Artery Occlusion Model of Stroke

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Cited by 11

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2023

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Abstracts

Replication and cerebrospinal fluid collection of permanent middle cerebral artery occlusion models in mice and rats

Yingfeng Zhang*1

1Guangzhou University of Chinese Medicine

Sprague Dawley model of ischemic stroke induced using Endothelin-1 vasoconstrictor

Suat Cheng Tan*1,

Nik Nur Hakimah Nik Salleh1,

Farah Amna Othman1

1Universiti Sains Malaysia

Photothrombosis and fiber photometry for induction and monitoring of focal ischemic stroke in behaving mice

Briana Montoya*1,

Roger Thompson2,

Andrew Boyce*1

1University of New Mexico,

2University of Calgary