
Rafael Bandeira Fabres
Federal University of Rio Grande do Sul and Collaborating Research of Federal University of the ABC, Brazil
Dr. Fabres graduated in Biomedicine (2013) with an emphasis on Clinical Pathology (Clinical Analysis). He completed a master's degree (2016) and a doctorate (2020) in Biological Sciences: Physiology from the Federal University of Rio Grande do Sul (UFRGS). He was a post-doctoral student at the laboratory of cerebral ischemia at UFRGS and was a collaborating researcher at the Federal University of ABC (UFABC). He is currently developing neuroprotective agents in injury models in the neurodevelopmental phase.

Silvia Honda
Federal University of the ABC, Brazil
Dr. Honda graduated in Physiotherapy from the University of São Paulo (1997) and worked for nine years at the Association for Assistance to Disabled Children (1998). She completed a master’s degree (2009) and a doctorate (2013) in Morphofunctional Sciences at the Institute of Biomedical Sciences of the University of São Paulo. She was responsible for the adaptation and validation of a non-invasive model of neonatal anoxia in rats and the study of its effects on activation, neuronal death, and hippocampal neurogenesis. She carried out a short internship at the NorthShore University Health System/University of Chicago (Illinois, USA) and was involved in developing research using an animal model of cerebral palsy. She is currently an adjunct professor at the Center for Mathematics, Computing and Cognition at UFABC and accredited in the Postgraduate Program of Neuroscience and Cognition at the same university.
Today, cerebrovascular disease, including stroke, is the leading cause of morbidity and mortality. It affects around 100 per 100,000 people worldwide. Due to the high prevalence of morbidity caused, stroke is also one of the main events that overload the health system in several countries. On the other hand, hypoxic-ischemic encephalopathy caused by perinatal asphyxia is a public health problem with persistent consequences during development. Therefore, searching for pre-clinical models that mimic its effects more closely than those found in the clinic becomes essential.
The effects of profound systemic hypotension and cerebral ischemia because of cardiac arrest can be mimicked by existing models. While these models mimic global ischemia, the use of focal cerebral ischemia models is preferred to understand the effects of stroke ischemia. The use of pre-clinical models is essential for developing new treatments that can reduce the consequences of these events. Therefore, the purpose of this collection is to demonstrate current standardized protocols that may provide alternatives for the study of event pathophysiology and the wider application of existing methods.
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2025
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Mozammel Bhuiyan1, Michelle Lin2, Carly McCurry1, Jessica Lamb1, Marcio A. Diniz3, Karni Bedirian3, Anil Chauhan4, Abhishek Jha4, Aditi Jain4, Enrique Leira5, Mohammad B. Khan6, Pradip K Kamat6, David C Hess6, Huaxin Sheng7, Bingren Hu8, Lauren H. Sansing9, Cenk Ayata10, Takahiko Imai10, Kirsten Lynch11, Patrick Lyden1,12
1Department of Physiology and Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine of USC, 2Department of Neurosurgery, Keck School of Medicine of USC, 3Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, 4Department of Internal Medicine, Division of Hematology, Oncology and Blood & Marrow Transplantation, Carver College of Medicine, University of Iowa, 5Departments of Neurology & Neurosurgery, Carver College of Medicine, Department of Epidemiology, College of Public Health, University of Iowa, 6The Medical College of Georgia at Augusta University, 7Department of Anesthesiology, Duke University, 8University of California, San Diego, 9Department of Neurology, Yale University, 10Neurovascular Research Unit, Massachusetts General Hospital, 11Laboratory of NeuroImaging, USC Mark and Mary Stevens Neuroimaging and Informatics Institute of the Keck School of Medicine of USC, 12Department of Neurology, Keck School of Medicine of USC
Replication and cerebrospinal fluid collection of permanent middle cerebral artery occlusion models in mice and rats
Yingfeng Zhang*1
1Guangzhou University of Chinese Medicine
Sprague Dawley model of ischemic stroke induced using Endothelin-1 vasoconstrictor
Suat Cheng Tan*1,
Nik Nur Hakimah Nik Salleh1,
Farah Amna Othman1
1Universiti Sains Malaysia
Photothrombosis and fiber photometry for induction and monitoring of focal ischemic stroke in behaving mice
Briana Montoya*1,
Roger Thompson2,
Andrew Boyce*1
1University of New Mexico,
2University of Calgary