Guest Editors
Dr. Roland Akhigbe
Department of Physiology, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria
Dr. Roland Akhigbe is a clinician and a faculty member at the Ladoke Akintola University of Technology. His interest is in Reproductive Toxicology and Ischemia/Reperfusion. Focusing on Ischemia/Reperfusion, his team has worked on various pathological problems, including contributions to our understanding of the pathogenesis of Ischemia/Reperfusion injury of the testis, ovaries, and intestine. He has also examined the modulation of Ischemia/Reperfusion-associated pathways through medical and surgical interventions. Dr. Roland heads the Reproductive Biology and Toxicology Research Laboratory, an arm of Oasis of Grace Hospital, Osogbo, Nigeria. He is a member of the Nigerian Medical Association, Medical and Dental Council of Nigeria, Physiological Society of Nigeria, and American Society of Andrology.
Dr. Jennifer Hughes
University of Illinois, Urbana-Champaign, USA
Dr. Jennifer Hughes is an independent researcher. She obtained her PhD in Animal Biology at the University of California, where she worked with Professor Trish Berger. Dr. Hughes is a recipient of several awards, including the NHIS Trainee Travel Award for 2012 and 2015 (American Society of Andrology), the Andrology Society Award of Extraordinary Service (2018), and the Male Contraceptive Initiative Travel Award (2022). She has worked in Charles Rivers Laboratories, KU Medical Centre, and Dr. Chip Muller Male Fertility Laboratory, University of Washington. Dr. Hughes is a member of the American Society of Andrology, the American Association of Cancer Research, and Society for the Study of Reproduction. Her research focuses on Epididymal Physiology and the Biology of Reproduction.
Victory Ashonibare
Friedrich Schiller University
Victory Ashonibare is a Microbiologist with a keen interest in Immunology and GUT microbiome. She graduated with first class in Landmark University, Omuaran, Nigeria, where she obtained a B.Sc. degree in Microbiology, then proceeded to Friedrich Schiller University, Jena, Germany, to obtain a master’s degree (M.Sc.) in Microbiology under the supervision of Prof. Dr. Christine Skerka and Prof. Dr. Peter Zipfel. She has worked at Landmark University, Nigeria and Leibniz Institute for Natural Products Research and Infection Biology, HKI, Jena, Germany. She is currently a Research Trainee, a team leader, and the Head of Projects at Reproductive Biology and Toxicology Research Laboratory (ReBTReL).
Collection Overview
Ischemia/reperfusion (I/R) is a life-threatening condition with high morbidity and mortality. It affects almost all organs and is associated with cascades of events triggered by the sudden disruption of blood flow and subsequent restoration of the blood flow. This leads to increased generation of reactive oxygen species, inflammation, and apoptosis. To date, the mechanisms of I/R injury still need to be fully understood, and the lack of appropriate models that mimic real-time clinical events hinders research. In an attempt to demonstrate the pathogenesis of I/R injury and improve the current management modalities, there have been increasing numbers of studies proposing appropriate models for the study of I/R injuries. The goal of this Methods Collection is to demonstrate suitable models and standardized protocols to better understand the mechanisms of I/R injuries, provide broader access to existing models, and ultimately improve I/R management.
