Kidney Infarct
Kidney Infarct - Related Videos
08:19
The Mouse Isolated Perfused Kidney Technique
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Cited by 24 •
2016
The mouse isolated perfused kidney (MIPK) is a technique for keeping a mouse kidney under ex vivo conditions perfused and functional for 1 hr. The buffers and surgical technique are described in detail.
07:45
Acute Myocardial Infarction in Rats
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Cited by 103 •
2011
The rat model of acute myocardial infarction (AMI) is useful to study the consequence of a MI on cardiac pathophysiological and physiological function.
09:45
Histological Quantification of Chronic Myocardial Infarct in Rats
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Cited by 14 •
2016
The post-mortem assessment of myocardial infarction (MI) in rodents is based on quantification of the infarct on stained heart sections. We describe an accurate method to quantify the infarct size using systematic sampling of harvested rat hearts from base to apex and image analyses of trichrome-stained histological sections.
01:45
Kidney Structure
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2019
The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries. The renal cortex is the thick outer layer of the kidney. It...
10:42
Normothermic Machine Perfusion of Rat Kidneys for Transplantation
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2026
This protocol describes the ex vivo normothermic machine perfusion of a rat kidney for subsequent transplantation into a recipient rat.
FAQs
Reduced perfusion deprives downstream nephrons of oxygen and nutrients. This ischemic stress disrupts cellular metabolism, so affected renal cells lose normal function and may progress toward tissue injury and necrosis. In a model, linking the perfusion change to the metabolic response helps investigators examine how vascular interruption translates into localized structural damage.
Coagulative necrosis represents the structural consequence of prolonged oxygen and nutrient deprivation, while inflammation reflects the tissue response to injury. Considering both processes helps researchers distinguish the initial damage from the response that follows. This distinction is useful when evaluating how renal tissue changes after vascular interruption and when assessing potential repair strategies.
The affected vascular territory determines which downstream nephrons experience ischemia. Damage confined to one region can therefore produce localized structural injury and reduced filtration in that area rather than an identical effect throughout the kidney. Mapping perfusion changes against nephron function helps connect vascular events with regional consequences for renal performance.
These models let bioengineers examine the relationship between altered blood flow, renal tissue damage, and repair. By focusing on a defined region of injury, researchers can investigate how perfusion changes influence kidney structure and function. The resulting observations support the design and evaluation of engineered systems intended to study renal vascular problems.
Engineered tissues and microfluidic systems provide bioengineering platforms for evaluating how altered blood flow affects kidney structure. Their value lies in connecting perfusion conditions with tissue responses in an experimental setting. Such platforms can help researchers investigate injury and repair processes while supporting the development of future regenerative or therapeutic approaches.
Imaging platforms can help evaluate structural changes associated with altered renal blood flow. When used alongside kidney infarct models, they provide a way to relate perfusion disturbances to the condition of affected tissue. This information supports analysis of localized damage and can help assess whether experimental strategies influence the injured region.
Computational simulations allow researchers to examine how changes in blood flow may affect kidney structure and regional tissue injury. Used with engineered tissues, microfluidic systems, or imaging platforms, simulations add a complementary analysis of perfusion-related outcomes. Together, these approaches can inform future regenerative and therapeutic strategies for damaged renal tissue.