C. Elegans Aging
C. Elegans Aging - Related Videos
06:44
Age-dependent Dynamics of Locomotion in Caenorhabditis elegans: A Lyapunov Exponent Analysis
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2025
This study examines the effect of age on locomotion in C. elegans by measuring the largest Lyapunov exponent (LLE). As they age, C. elegans show an increase and subsequent decline in motor control. Results show a peak LLE at five days, followed by a decline as the worms age.
11:34
Basic Caenorhabditis elegans Methods: Synchronization and Observation
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Cited by 452 •
2012
The easiness of maintaining and propagating the nematode C. elegans make it a nice model organism to work with. The possibility of synchronizing worms allows the work with a significant amount of subjects at the same developmental stage, what facilitates the study of one particular process in many animals.
11:57
Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans
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Cited by 7 •
2017
The goal of the method presented here is to explore protein aggregation during normal aging in the model organism C. elegans. The protocol represents a powerful tool to study the highly insoluble large aggregates that form with age and to determine how changes in proteostasis impact protein aggregation.
10:54
C. elegans Maintenance
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2023
Ceanorhabditis elegans has been, and is still, used to great success as a model organism for studying a variety of developmental, genetic, molecular and even physical phenomena. In order to use C. elegans to its full potential, proper care and attention to the basic maintenance of this powerful organism is essential. In this video you will learn the basic housing and feeding requirements of C. elegans, how to correctly handle and manipulate worms using a worm pick and how to freeze and recover...
09:13
An Introduction to Caenorhabditis elegans
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2023
Caenorhabditis elegans is a microscopic, soil-dwelling roundworm that has been powerfully used as a model organism since the early 1970’s. It was initially proposed as a model for developmental biology because of its invariant body plan, ease of genetic manipulation and low cost of maintenance. Since then C. elegans has rapidly grown in popularity and is now utilized in numerous research endeavors, from studying the forces at work during locomotion to studies of neural circuitry. This video...
FAQs
The DAF-2 and DAF-16 relationship provides a mechanistic way to connect signaling with aging outcomes. Insulin/IGF-1 signaling through DAF-2 is examined alongside DAF-16, a transcription factor that regulates genes associated with stress resistance and longevity. This framework lets investigators ask whether altered signaling changes the worm’s ability to resist stress and maintain longer-term survival.
DAF-16 is important because it connects an aging-related signaling pathway to changes in gene regulation. As a transcription factor, it regulates genes linked with stress resistance and longevity, allowing researchers to study how signaling influences physiological resilience. Examining DAF-16 therefore helps identify molecular mechanisms that may contribute to differences in survival and age-related decline.
Genetic and environmental factors can influence aging through different but interacting routes. Researchers can use the worm’s genetic tractability to examine candidate genes or pathways, while defined dietary conditions provide an environmental variable. Studying both types of influence helps clarify whether changes in lifespan or physiological function arise from inherited regulation, external conditions, or their combined effects.
A study can use the worm’s short lifespan and defined development to evaluate how a genetic change, dietary condition, or candidate intervention affects aging. Researchers track outcomes related to lifespan and healthspan under the selected conditions, then compare those outcomes across experimental contexts. This design supports relatively efficient testing of mechanisms that would be harder to examine over longer lifetimes.
Measuring both healthspan and lifespan separates continued physiological function from survival time alone. An intervention may affect how long worms remain functionally healthy, how long they live, or both. Including these outcomes gives aging studies a broader interpretation and helps determine whether a candidate factor influences general longevity, age-related functional decline, or the relationship between them.
C. elegans combines a short lifespan, defined development, and genetic tractability, making it practical for testing conserved biological pathways. Researchers can investigate insulin/IGF-1 signaling, dietary conditions, and candidate interventions, then examine effects on healthspan and lifespan. Findings from this model can provide insight into cellular mechanisms of aging and help identify potential targets for age-related disease research.