Delayed Burst Release
Delayed Burst Release - Related Videos
03:50
A Technique to Generate a Novel Delivery Platform for a Delayed Burst Release of Molecules
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2025
This video demonstrates a method for the generation of a polymer bubble or polybubble-based novel platform that enables delayed burst release. Polyester-based polymers are used to form the polybubbles with core-shell structure, and small molecules and antigens can be used as cargo.
01:11
Oral Drug Delivery Systems: Delayed-Release Systems
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2026
Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...
07:05
The Precision of Visual Working Memory with Delayed Estimation
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2023
Source: Laboratory of Jonathan Flombaum—Johns Hopkins University Human memory is limited. Throughout most of its history, experimental psychology has focused on investigating the discrete, quantitative limits of memory—how many individual pieces of information a person can remember. Recently, experimental psychologists have also become interested in more qualitative limits—how precisely is information stored? The concept of memory precision can be both intuitive and elusive at once. It is...
07:47
Measuring Delay Discounting in Humans Using an Adjusting Amount Task
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Cited by 55 •
2016
Delay discounting refers to a decline in the value of a reward when it is delayed relative to when it is immediately available. We outline a computer-based delay discounting task that is easy to implement and allows for the quantification of the degree of delay discounting in human participants.
04:09
Continuous Theta Burst Stimulation to Reduce Responses to Ideological Threats
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2025
Source: Holbrook, C., et al. Continuous Theta Burst Stimulation of the Posterior Medial Frontal Cortex to Experimentally Reduce Ideological Threat Responses. J. Vis. Exp. (2018)This video demonstrates the application of continuous theta burst stimulation (cTBS) to modulate responses to ideological threats. Electromyography (EMG) electrodes record motor signals, while a magnetic coil stimulates the primary motor cortex to determine the active motor threshold (aMT). The coil is then repositioned...
FAQs
The timing depends on how quickly the protective barrier changes its transport properties. While a coating or matrix remains relatively restrictive, movement of the payload is limited. Swelling can open pathways, whereas erosion or degradation can remove material that blocks diffusion. These distinct transitions help explain why release may accelerate sharply rather than gradually.
Environmental conditions can determine when the transition occurs. A system may respond to pH or enzymes, so the surrounding biological setting becomes part of the release design. The relevant condition can influence swelling, erosion, or degradation of the barrier, thereby shifting both the length of the delay and the speed of the subsequent discharge.
Delayed Burst Release differs from a profile that delivers payload immediately because it separates two phases: preserving retention during the initial interval and permitting rapid discharge afterward. This distinction creates a timing-based design challenge. It matters when exposure should remain limited early but increase later in response to a biological process or therapeutic requirement.
Characterization focuses on two measurable features: the duration of the initial delay and the rate of release after the burst begins. Researchers track payload availability over time under the intended conditions, then examine whether the observed profile shows prolonged retention followed by rapid discharge. These measurements reveal whether timing is predictable enough for the planned application.
Testing should account for the barrier and its environment rather than evaluating the payload alone. A study can compare release while the coating or matrix is exposed to relevant pH or enzymatic conditions, recording how long retention persists and how quickly discharge follows. This approach links the measured profile to the mechanism responsible for the delay.
In biology and biomedical research, the profile is useful when treatment should coincide with a disease process or remain concentrated near a target site. Delaying discharge can reduce premature exposure, while the later burst can provide rapid local payload availability. Researchers therefore assess both timing and release rate when judging therapeutic delivery performance.