First-order Autoregressive

First-order autoregressive is a time-series model in which the current value is predicted from its immediately preceding value and a random innovation, making it useful for representing dependence across observations. In the model X_t = c + φX_{t−1} + ε_t, the coefficient φ controls temporal persistence, while ε_t captures new variation; when |φ| < 1, the process is typically stationary around its long-term mean. In biology, this framework helps analyze repeated physiological measurements, population or ecological records, and other longitudinal data by quantifying autocorrelation, separating signal from noise, and supporting forecasting or simulation of biological dynamics.

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JoVE Journal - Biology

Isolation and Derivation of Mouse Embryonic Germinal Cells

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Cited by 4 •

2009

The ability of embryonic germinal cells to differentiate into primordial germinal cells during early development stages is a perfect model to address our hypothesis about cancer and infertility. This protocol shows how to isolate primordial germinal cells from developing gonads in 10.5-11.5 days post coitum mouse embryos.

Real-Time Electroencephalography-Triggered Transcranial Magnetic Stimulation for Cortical Excitation

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2025

Source: Stefanou, M., et.al. Brain State-dependent Brain Stimulation with Real-time Electroencephalography-Triggered Transcranial Magnetic Stimulation. J. Vis. Exp. (2019)This video demonstrates the process of real-time EEG-triggered transcranial magnetic stimulation (TMS) to study cortical excitability. The procedure involves positioning the TMS coil over the motor cortex, synchronizing stimulation with specific phases of the EEG signal, and recording motor-evoked potentials (MEPs) to explore...

Lentiviral Mediated Gene Silencing in Human Pseudoislet Prepared in Low Attachment Plates

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Cited by 9 •

2019

A protocol to create gene modified human pseudoislets from dispersed human islet cells that are transduced by lentivirus carrying short hairpin RNA (shRNA) is presented. This protocol utilizes readily available enzyme and culture vessels, can be performed easily, and produces genetically modified human pseudoislets suitable for functional and morphological studies.

Frontal Disconnection for Treating Mild Malformation of Cortical Development with Oligodendroglial Hyperplasia in Epilepsy (MOGHE) in the Frontal Lobe

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Cited by 3 •

2024

Here, we present a protocol to describe the epilepsy outcome and complications of 8 patients with mild malformation of cortical development with oligodendroglial hyperplasia in epilepsy (MOGHE) in the frontal lobe after frontal disconnection. The procedure is characterized by its simplicity, user-friendliness, and fewer postoperative complications.

Preparation of Acute Spinal Cord Slices for Whole-cell Patch-clamp Recording in Substantia Gelatinosa Neurons

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Cited by 6 •

2019

Here, we describe the essential steps for whole-cell patch-clamp recordings made from substantia gelatinosa (SG) neurons in the in vitro spinal cord slice. This method allows the intrinsic membrane properties, synaptic transmission and morphological characterization of SG neurons to be studied.

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