Fractal Globule Conformation
Fractal Globule Conformation - Related Videos
01:20
Conformity
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2020
Conformity is the change in a person’s behavior to go along with the group, even if that person does not agree with the group. Asch’s Original Study Solomon Asch conducted several experiments in the 1950s to determine how people are affected by the thoughts and behaviors of other people. In one study, a group of participants was shown a series of printed line segments of different lengths: a, b, and c. Participants were then shown a fourth line segment: x. They were asked to identify which...
08:55
A Minority of One: Conformity to Group Norms
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2023
Source: William Brady & Jay Van Bavel—New York University It is obvious that we are influenced by those around us, but in the early to mid 1900's, psychologists began to study how potent social influence can be on our thoughts and behaviors. Motivated in part by attempts to explain the behaviors of Nazi soldiers in World War II, one topic of considerable interest at the time in psychology was conformity, the phenomenon in which people match their attitudes, behaviors, or beliefs to group...
10:37
Spatial Separation of Molecular Conformers and Clusters
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Cited by 3 •
2014
We present a technique that allows the spatial separation of different conformers or clusters present in a molecular beam. An electrostatic deflector is used to separate species by their mass-to-dipole moment ratio, leading to the production of gas-phase ensembles of a single conformer or cluster stoichiometry.
08:50
Fabrication and Characterization of a Conformal Skin-like Electronic System for Quantitative, Cutaneous Wound Management
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Cited by 7 •
2015
This article presents methods to fabricate and characterize a conformal, skin-like electronic system and protocols for the use in clinical applications, particularly on cutaneous wound management.
02:20
Conformations of Butane
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2025
Unlike ethane and propane that have only two major conformations, butane has more than two conformers. The staggered form of butane in which the bulky methyl groups on the two carbons are placed on opposite sides, that is, at a dihedral angle of 180°, is the lowest energy, most stable form — called the anti conformer. This conformation is stabilized due to the absence of steric repulsion between the largely spaced out methyl groups. The other two staggered conformations are degenerate and have...
FAQs
Hierarchical collapse organizes the polymer across multiple length scales rather than producing only a locally compact arrangement. This self-similar pattern links nearby segments with broader chromosome organization, allowing researchers to consider local folding and long-range relationships within one structural model. It therefore provides a framework for interpreting how genomic material maintains organization while occupying limited nuclear space.
A knot-free structure allows different polymer regions to fold compactly without extensive interpenetration. Neighboring segments can remain close while distinct regions retain spatial separation, preserving organization within the packed material. In chromatin, this feature helps explain how dense chromosome folding can coexist with identifiable domains instead of producing an entirely mixed structure.
The model addresses two competing structural requirements: chromosomes must fit densely inside the nucleus, yet their organization must preserve access to particular genomic regions. By maintaining local and long-range order during compaction, the conformation provides a physical basis for examining how folding patterns may influence the spatial organization and regulation of chromatin.
Self-similarity means that organizational features recur across different structural scales. This gives researchers a way to connect the arrangement of nearby polymer segments with larger chromosomal domains rather than treating each scale independently. For biology, that relationship is useful when interpreting genome architecture and asking how local folding contributes to the overall arrangement of chromosomes.
The model supports research on genome architecture, chromatin interactions, gene regulation, and the physical principles governing chromosome folding. These areas use the conformation as a framework for connecting spatial organization with biological function. It is especially relevant when investigators need to relate compact nuclear packaging to the maintenance of distinct genomic regions and their regulated accessibility.
It can help researchers investigate how chromatin forms spatial domains while remaining densely packed inside the nucleus. Because neighboring segments stay close and separate regions do not extensively interpenetrate, the model provides a basis for examining domain organization and interactions. These structural insights can then inform studies of genomic-region access and gene regulation.