Lung Microvasculature
Lung Microvasculature - Related Videos
02:58
Two-Photon Microscopy for In Vivo Imaging of Mouse Brain Microvasculature
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2025
Source: Nishimura, C. et al. Quantification of Cerebral Vascular Architecture using Two-photon Microscopy in a Mouse Model of HIV-induced Neuroinflammation. J. Vis. Exp. (2016). This video demonstrates the in vivo visualization of cortical capillaries in the mouse brain using two-photon microscopy. It outlines the steps for injecting a fluorescent dye into an anesthetized mouse with a thin-skull cortical window, preparing the setup for imaging, and acquiring detailed images of brain...
09:39
Spatial Temporal Analysis of Fieldwise Flow in Microvasculature
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Cited by 7 •
2019
To quantify microvascular flow from high speed capillary flow image sequences, we developed STAFF (Spatial Temporal Analysis of Fieldwise Flow) software. Across the full image field and over time, STAFF evaluates flow velocities and generates a sequence of color-coded spatial maps for visualization and tabular output for quantitative analyses.
04:11
DCE-MRI of Orthotopic Pancreatic Tumor Xenografts: A Method to Assess Microvasculature in a Target Tumor Tissue
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2023
This video describes the technique of DCE-MRI for orthotropic pancreatic tumor xenografts in mice. DCE-MRI is a non-invasive method to analyze microvasculature in a target tissue, and useful to assess vascular response in a tumor following a novel therapy. This method will assist investigators to apply DCE-MRI for orthotopic gastrointestinal cancer mouse models.
07:06
A Simple Method of Mouse Lung Intubation
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Cited by 50 •
2013
This paper describes a striaghforward and efficient method of intubating mice for pulmonary function measurements or pulmonary instillation, that allows the mice to recover and be studied at later times. The procedure involves an inexpensive fiberoptic light source that directly illuminates the trachea.
01:47
Lung Capacity
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2019
The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures. There are four defined lung volume measures: tidal volume, inspiratory reserve volume, expiratory reserve volume, and residual volume. Tidal volume is the amount of air inhaled and exhaled in a normal breath. Inspiratory...
FAQs
Endothelial cells help control how fluid moves across the small pulmonary vessels and regulate vascular tone, meaning the degree of vessel constriction or relaxation. These activities affect the local vascular environment around the alveoli and support effective pulmonary circulation. Because endothelial regulation is tied to fluid movement, it provides an important biological connection between microvascular function and pulmonary edema research.
The alveolar-capillary barrier places the blood-facing vessel surface and the alveolar epithelium in close contact, with very thin intervening walls. This arrangement supports diffusion of oxygen into blood and carbon dioxide out of it. Studying this barrier helps explain how the lung maintains blood gas exchange and provides a framework for examining conditions that interfere with normal pulmonary function.
Efficient respiration requires coordination between air reaching the alveoli and blood passing through nearby vessels. The lung microvasculature contributes to this ventilation-perfusion matching by directing pulmonary circulation through the gas-exchange region. When researchers examine this relationship, they can connect vascular organization with the lung’s ability to oxygenate blood and remove carbon dioxide effectively.
The pulmonary microvascular system is relevant to pulmonary edema, inflammation, thrombosis, and vascular remodeling. These processes represent different ways the vessels may become involved in disease, including abnormal fluid accumulation, inflammatory activity, clot formation, or structural change. Investigating them allows researchers to relate microvascular biology to broader patterns of respiratory disease and altered pulmonary circulation.
Research on lung microvasculature can connect cellular and vascular behavior with clinically important respiratory problems. In particular, investigators can examine how endothelial regulation, the alveolar-capillary barrier, fluid movement, and vascular remodeling relate to pulmonary edema, inflammation, or thrombosis. This focus helps clarify disease mechanisms while keeping gas exchange and pulmonary circulation central to interpretation.
The pulmonary microvascular network provides an important biological context for developing approaches in drug delivery, tissue engineering, and regenerative medicine. Its close relationship with alveolar tissue and gas exchange makes vascular organization relevant when researchers consider how lung tissue is supported or restored. These applications extend microvascular research beyond disease description toward strategies for investigating and rebuilding respiratory tissues.