Periprosthetic Infection
Periprosthetic Infection - Related Videos
04:37
A Periprosthetic Joint Candida albicans Infection Model in Mouse
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2024
Periprosthetic joint infection (PJI) caused by dangerous pathogens is common in clinical orthopedics. Existing animal models cannot accurately simulate the actual situation of PJI. Here, we established a Candida albicans biofilm-associated PJI mouse model to research and develop new therapeutics for PJI.
18:40
Combined In vivo Optical and µCT Imaging to Monitor Infection, Inflammation, and Bone Anatomy in an Orthopaedic Implant Infection in Mice
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Cited by 19 •
2014
Combined optical and μCT imaging in a mouse model of orthopaedic implant infection, utilizing a bioluminescent engineered strain of Staphylococcus aureus, provided the capability to noninvasively and longitudinally monitor the dynamics of the bacterial infection, as well as the corresponding inflammatory response and anatomical changes in the bone.
12:30
Use of Galleria mellonella as a Model Organism to Study Legionella pneumophila Infection
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Cited by 108 •
2013
The larva of the wax moth Galleria mellonella was recently established as an in vivo model to study Legionella pneumophila infection. Here, we demonstrate fundamental techniques to characterize the pathogenesis of Legionella in the larvae, including inoculation, measurement of bacterial virulence and replication as well as extraction and analysis of infected hemocytes.
07:59
Bioluminescence Imaging to Detect Late Stage Infection of African Trypanosomiasis
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Cited by 3 •
2016
This manuscript describes the use of a bioluminescent strain of African trypanosomes to enable the tracking of late stage infection and demonstrates how in vivo live imaging can be used to visualize infections within the central nervous system in real-time.
12:38
4D Multimodality Imaging of Citrobacter rodentium Infections in Mice
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Cited by 19 •
2013
Multi-modality imaging is a valuable approach for studying bacterial colonization in small animal models. This protocol outlines infection of mice with bioluminescent Citrobacter rodentium and the longitudinal monitoring of bacterial colonization using composite 3D diffuse light imaging tomography with μCT imaging to create a 4D movie of C. rodentium infection.
FAQs
Microbes can reach an implanted prosthesis during surgery or later through the bloodstream. Once introduced, they can interact with implant surfaces and adjacent tissue. This makes both the timing and route of exposure relevant to understanding how infection begins and to designing prevention strategies in orthopedic research.
Biofilms can make bacteria harder for the immune system to clear and can reduce antibiotic effectiveness. Their formation on an implant surface changes the biological environment from a freely exposed microbial presence to a more persistent surface-associated problem. This mechanism helps explain why treatment may include antimicrobial therapy alongside surgery involving the implant or surrounding tissue.
The infection may compromise implant function and patient recovery, so its significance extends beyond detecting microbes alone. In biology and orthopedic research, investigators therefore examine interactions among bacteria, the prosthesis, surrounding tissue, and host defenses to understand how infection can interfere with recovery of an implanted system.
Diagnosis requires a combined assessment rather than one isolated measurement. Clinical findings may be integrated with laboratory tests and imaging, followed by analysis of blood or tissue samples for additional evidence. Using these sources together supports a more informed evaluation and connects observed biological changes with the condition of the implant and surrounding tissue.
Treatment may include targeted antibiotics, surgical debridement, implant retention, or prosthesis revision. These options represent different ways of addressing microbial activity, infected surrounding tissue, and the prosthesis itself. In periprosthetic infection research, examining these approaches is relevant to preserving implant function while supporting patient recovery.
Studying periprosthetic infection can guide improvements in aseptic techniques, implant materials, preventive strategies, and patient outcomes. The topic connects microbial behavior with implanted materials, surrounding tissue, and immune clearance. Consequently, it provides a research context for improving orthopedic procedures and broader biomedical approaches to prosthesis-associated complications.