Stereotaxic Frame
Stereotaxic Frame - Related Videos
08:28
Rodent Stereotaxic Surgery
0 Views •
2023
Stereotaxic (or stereotactic) surgery is a method used to manipulate the brain of living animals. This technique allows researchers to accurately target deep structures within the brain through the use of a stereotaxic atlas, which provides the 3D coordinates of each area with respect to anatomical landmarks on the skull. After the skull is exposed, anesthetized animals are mounted on a specialized instrument known as a stereotaxic frame, which enables the precise placement of experimental...
03:26
Framing Effects
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2020
Information is everywhere and its presentation—such as how and when items are presented—can impact our perceptions and decisions surrounding the info. This broad concept umbrellas framing effects—influences that occur due to the way information is framed in its appearance, whether it’s purely the order or the specific wording of a message. Let’s take a look at numerous ways in which two versions of something can objectively say the same thing, yet we respond in different ways based on the...
09:09
Dissecting the Non-human Primate Brain in Stereotaxic Space
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Cited by 14 •
2009
The non-human primate is an important translational species for our understanding of the normal processing of the brain. The anatomical organization of the primate brain can provide important insights into normal and pathological conditions in humans.
01:30
Frames
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2023
Frames are essential components of various mechanical and structural systems used daily. These structures are known for their stability and ability to bear heavy loads. A frame is constructed using two-force and multi-force members, interconnected using pin joints. In contrast, trusses are made entirely of two-force members. Frames are versatile and widely used in various applications such as structural supports for beams and columns, automobile chassis construction, and in the construction...
00:08
Survivable Stereotaxic Surgery in Rodents
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Cited by 50 •
2008
The monitoring of extracellular neurotransmitter levels in distinct brain regions of freely moving animals offers insights on the link between neurotransmitter release and behavior. In vivo microdialysis coupled with electrochemical detection provides excellent anatomical and chemical resolution; and information on how basal neurotransmission is altered by pharmacological or physiological manipulations.
FAQs
The adjustable coordinate mechanism positions a probe, electrode, cannula, or injection needle relative to a defined reference point. Researchers set the desired location in three dimensions, then control the instrument’s direction and depth during placement. This organized positioning links the intended target with a reproducible physical trajectory through the brain.
A stereotaxic atlas or established reference point provides the spatial framework for selecting a brain target. It allows researchers to relate the planned location to three-dimensional coordinates rather than relying only on visual judgment. Using the same reference system across experiments supports more consistent placement and makes results easier to compare.
Rigid fixation limits movement of the animal’s head while an instrument is positioned, whereas controlled depth and direction determine the path toward the intended site. Together, these features reduce variation caused by shifting or imprecise advancement. Greater placement consistency is especially important when experiments depend on affecting or recording from a discrete brain region.
A typical workflow establishes rigid head fixation, identifies the target using a stereotaxic atlas or reference point, and adjusts the coordinate mechanism to align the selected instrument. The probe, electrode, cannula, or needle is then advanced along a controlled trajectory and to a defined depth. The resulting intervention or recording can be examined alongside anatomical or behavioral outcomes.
The frame can guide probes, electrodes, cannulas, and injection needles. The instrument selected depends on the experimental objective: electrodes collect neural signals, cannulas or injection needles deliver substances, and other guided tools support localized interventions or examination of brain regions. In each case, the coordinate system determines where the instrument is directed and how deeply it advances.
These experiments can test how discrete brain regions contribute to neural circuits, brain function, disease mechanisms, and experimental therapies. Researchers may deliver substances, record neural activity, create localized lesions, or assess anatomy and behavior after a targeted intervention. Because placement is controlled and reproducible, observed outcomes can be related more specifically to the selected region.