Trabecular Sinus
Trabecular Sinus - Related Videos
09:03
Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye
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Cited by 7 •
2015
Trabecular meshwork (TM) migration into Schlemm’s canal space can be induced by acute pressure elevation by ophthalmodynamometer, and observed by spectral domain optical coherence tomography. The goal of this method is to quantify the morphometric response of the living outflow tract to acute pressure elevation in living tissues in situ.
08:46
Nose, Sinuses, Oral Cavity and Pharynx Exam
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2023
Source: Richard Glickman-Simon, MD, Assistant Professor, Department of Public Health and Community Medicine, Tufts University School of Medicine, MA This video provides an overview of sinus, nose, and throat examinations. The demonstration begins with a brief overview of the anatomy of the region. The upper third of the nose is bony, and the bottom two-thirds are cartilaginous. Air entering the nares passes through the nasal vestibules and into the narrow passageway between the nasal septum...
06:43
Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus
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Cited by 51 •
2013
We describe procedures to quantify and characterize atherosclerotic lesions in mouse models using precision sectioning of the aortic sinus and ascending aorta combined with histochemical and immunohistochemical analysis.
07:34
Establishment of a Modified Ferric Chloride-Induced Superior Sagittal Sinus Thrombosis
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2025
This study presents a protocol for establishing a reproducible, minimally invasive rat model of superior sagittal sinus thrombosis induced by ferric chloride, utilizing a silk-suture method in combination with laser speckle contrast imaging and high-resolution ultrasound for evaluation.
08:44
Formation of Human Prostate Epithelium Using Tissue Recombination of Rodent Urogenital Sinus Mesenchyme and Human Stem Cells
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Cited by 10 •
2013
To unravel the earliest molecular mechanisms underlying prostate cancer initiation, novel and innovative human model systems and approaches are desperately needed. The potential of pre-prostatic urogenital sinus mesenchyme (UGSM) to induce pluripotent stem cell populations to form human prostate epithelium is a powerful experimental tool in prostate research.
FAQs
Lymph enters from the subcapsular region and travels inward along connective-tissue trabeculae. As it passes through the sinus, the reticular fiber network slows and organizes fluid movement, allowing suspended material to encounter immune cells. The filtered lymph then continues toward the medullary sinuses before leaving through an efferent lymphatic vessel.
The reticular fiber network creates an internal framework within the sinus rather than allowing lymph to pass as an unstructured stream. This organization brings particles, pathogens, and cellular debris into proximity with macrophages and other antigen-presenting cells. Its arrangement therefore supports efficient filtration and gives immune cells opportunities to detect material carried in lymph.
Macrophages can capture particles, pathogens, and cellular debris as lymph moves through the channel. Other antigen-presenting cells contribute to immune surveillance by handling material encountered in the filtered fluid. Together, these cells connect lymph filtration with the possibility of initiating an immune response, making the sinus an active cellular checkpoint rather than merely a drainage space.
Its position creates an intermediate route within the lymph node. Lymph arriving in the subcapsular sinus can move inward along connective-tissue trabeculae, pass through the trabecular sinus, and then reach the medullary sinuses. This sequence distributes lymph through successive regions, supporting organized screening before fluid exits through an efferent lymphatic vessel.
Histology assessment should consider the sinus’s relationship to connective-tissue trabeculae, the reticular fiber network within it, and the presence of macrophages or other antigen-presenting cells. Researchers can also compare its architecture with the medullary sinuses and surrounding node regions. These observations help determine how the node organizes lymph filtration and immune surveillance.
Changes in the architecture of these channels may provide clues about processes affecting the lymph node, including inflammation, infection, or lymphoid disease. Interpretation depends on examining the sinus within the broader node structure rather than in isolation. Because the channel participates in lymph screening and immune surveillance, structural abnormalities may reflect disruption of those functions.