Endobronchial Biopsy
Endobronchial Biopsy - Related Videos
10:19
Substernal Thyroid Biopsy Using Endobronchial Ultrasound-guided Transbronchial Needle Aspiration
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Cited by 7 •
2014
Substernal thyroid lesions are common, and need to be differentiated from malignancy. Obtaining percutaneous fine needle biopsy is not possible due to its retrosternal location. This article proposes a protocol for biopsy of substernal thyroid lesions using Endobronchial Ultrasound-guided Transbronchial Needle Aspiration (EBUS-TBNA).
11:02
Human Lung Dendritic Cells: Spatial Distribution and Phenotypic Identification in Endobronchial Biopsies Using Immunohistochemistry and Flow Cytometry
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Cited by 11 •
2017
Lung-resident immune cells, including dendritic cells (DCs) in humans, are critical for defense against inhaled pathogens and allergens. However, due to the scarcity of human lung tissue, studies are limited. This work presents protocols to process human mucosal endobronchial biopsies for studying lung DCs using immunohistochemistry and flow cytometry.
05:22
Systematic Endobronchial Ultrasound - The Six Landmarks Approach
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Cited by 1 •
2023
Endobronchial ultrasound-guided sampling using transbronchial needle aspiration plays a key role in staging and diagnosing lung cancer. We propose a systematic stepwise approach dividing the procedure into six landmarks that should be taught to new operators.
04:35
Using the Endoscope for Endobronchial Ultrasound in the Esophagus
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2023
Transesophageal ultrasound (EUS-B) is a safe and feasible procedure using the echoendobronchoscope (EBUS) in esophagus and stomach. After identifying six anatomical landmarks, additional structures can be identified and biopsied, sparing subsequent diagnostic sessions. Thus, EUS-B is an ideal continuation of bronchoscopy and EBUS in diagnosing lung cancer and other diseases.
05:26
A Standardized Liquid Biopsy Preanalytical Protocol for Downstream Circulating-Free DNA Applications
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Cited by 3 •
2022
The liquid biopsy has revolutionized our approach to oncology translational studies, with sample collection, quality, and storage being crucial steps for its successful clinical application. Here we describe a standardized and validated protocol for downstream circulating-free DNA applications that can be applied in most translational research laboratories.
FAQs
The tissue preserves cellular architecture and tumor morphology, allowing investigators to examine malignant changes within the airway. Researchers can relate these microscopic features to tumor classification and assess whether the sampled lesion provides clinically relevant evidence. This makes the specimen useful for connecting airway abnormalities with the biological characteristics needed for cancer-focused investigation.
Biomarker analysis adds information beyond the visible tissue pattern. When appropriate, preserved biopsy material can undergo molecular analysis to identify characteristics associated with the tumor. Combining morphology with biomarker findings supports more detailed characterization and contributes to precision-oriented investigation, particularly when researchers need to relate tissue features to clinically relevant tumor evidence.
Comparing tumor tissue with samples from surrounding airway areas provides a reference for interpreting the lesion. The contrast can help investigators distinguish findings associated with malignant tissue from features present in nearby airway material. In cancer research, this paired perspective strengthens evaluation of tumor characteristics and supports studies examining how abnormal tissue relates to its local environment.
Preservation determines whether the collected tissue remains suitable for the planned examination. The specimen must be handled so it can support microscopic assessment and, when appropriate, molecular analysis. Maintaining usable material expands the information obtained from a small sample, allowing investigators to examine morphology, biomarkers, or both rather than limiting the study to visual findings alone.
After forceps collect tissue under direct visualization, the specimen is preserved for laboratory examination. Investigators then use it for microscopic analysis and, when appropriate, molecular testing. The resulting findings can characterize tumor morphology and biomarkers, creating a tissue-based record that supports diagnosis, classification, and cancer research rather than relying only on airway appearance.
Researchers use these samples when they need tissue-based evidence from an airway lesion or abnormal mucosa. The material can support diagnosis, tumor characterization, biomarker evaluation, and assessment of treatment response. Studies may also compare tumor tissue with surrounding airway samples, linking a minimally invasive sampling approach to clinically relevant questions in cancer investigation.